8ATS

Small molecular stabilizer for C-RAF (pS259) and 14-3-3 (1075306)

Summary for 8ATS

Entry DOI	10.2210/pdb8ats/pdb
Descriptor	14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	14-3-3, eralpha, stabilization, covalent, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	28133.66
Authors	Visser, E.J.,Overmans, M.J.A.M.,Vandenboorn, E.M.F.,Ottmann, C. (deposition date: 2022-08-24, release date: 2023-09-20, Last modification date: 2023-10-04)
Primary citation	Konstantinidou, M.,Visser, E.J.,Vandenboorn, E.,Chen, S.,Jaishankar, P.,Overmans, M.,Dutta, S.,Neitz, R.J.,Renslo, A.R.,Ottmann, C.,Brunsveld, L.,Arkin, M.R. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3 sigma /ER alpha Protein-Protein Interaction from Nonselective Fragments. J.Am.Chem.Soc., 145:20328-20343, 2023 Cited by PubMed: 37676236 DOI: 10.1021/jacs.3c05161 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation