7S3G
 
 | | Structure of cofactor pyridoxal 5-phosphate bound human ornithine decarboxylase in complex with citrate at the catalytic center | | 分子名称: | CITRIC ACID, Ornithine decarboxylase, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Zhou, X.E, Suino-Powell, K, Schultz, C.R, Aleiwi, B, Brunzelle, J.S, Lamp, J, Vega, I.E, Ellsworth, E, Bachmann, A.S, Melcher, K. | | 登録日 | 2021-09-06 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane.
Biochem.J., 478, 2021
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9GMY
 | | Tubulin in complex with an oxathiane analog of zampanolide | | 分子名称: | (2Z,4E)-N-[(S)-[(1R,2E,5S,8E,10Z,17S)-3,11-dimethyl-7,13-bis(oxidanylidene)-6,21-dioxa-19-thiabicyclo[15.3.1]henicosa-2,8,10-trien-5-yl]-oxidanyl-methyl]hexa-2,4-dienamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Oliva, M.A, Diaz, J.F, Altmann, K.H. | | 登録日 | 2024-08-30 | | 公開日 | 2025-09-10 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Tubulin in complex with an oxathiane analog of zampanolide
To Be Published
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7SSE
 | | Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70 | | 分子名称: | DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine | | 著者 | Kimani, S, Owen, J, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Shahani, V.M, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2021-11-10 | | 公開日 | 2021-12-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
J.Chem.Inf.Model., 63, 2023
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9GNO
 | | Crystal structure of CDK2 bound by compound 4 | | 分子名称: | (2R)-2-[(9-isopropyl-6-{[(3S)-1-(methylsulfonyl)-3-pyrrolidinyl]amino}-9H-purin-2-yl)amino]-3-methyl-1-butanol, Cyclin-dependent kinase 2 | | 著者 | Collie, G.W, Pflug, A. | | 登録日 | 2024-09-03 | | 公開日 | 2025-09-10 | | 最終更新日 | 2025-09-24 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.
J.Med.Chem., 68, 2025
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1M2I
 | | Crystal structure of E44A/E56A mutant of cytochrome b5 | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome b5 | | 著者 | Wu, J, Wang, Y.-H, Gan, J.-H, Wang, W.-H, Sun, B.-Y, Huang, Z.-X, Xia, Z.-X. | | 登録日 | 2002-06-24 | | 公開日 | 2003-03-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of Cytochrome b5 Mutated at the Charged Surface-Residues and Their Interactions with Cytochrome c
Chin.J.Chem., 20, 2002
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9GI6
 | | Structure of SARS-CoV-2 Main Protease (Mpro) with mutation of N214A | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Replicase polyprotein 1a, ... | | 著者 | Creon, A, Scheer, T.E.S, Lane, T.J, Rahmani Mashhour, A, Guenther, S, Reinke, P.Y.A, Meents, A, Chapman, H.N. | | 登録日 | 2024-08-17 | | 公開日 | 2025-09-03 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structure of SARS-CoV-2 Main Protease (Mpro) with mutation of N214A
To Be Published
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1M2Q
 | | Crystal structure of 1,8-di-hydroxy-4-nitro-xanten-9-one/CK2 kinase complex | | 分子名称: | 1,8-DI-HYDROXY-4-NITRO-XANTHEN-9-ONE, Casein kinase II, alpha chain | | 著者 | De Moliner, E, Sarno, S, Moro, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R. | | 登録日 | 2002-06-25 | | 公開日 | 2003-06-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Inhibition of protein kinase CK2 by anthraquinone-related compounds. A
structural insight
J.Biol.Chem., 278, 2003
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1M32
 | | Crystal Structure of 2-aminoethylphosphonate Transaminase | | 分子名称: | 2-aminoethylphosphonate-pyruvate aminotransferase, PHOSPHATE ION, PHOSPHONOACETALDEHYDE, ... | | 著者 | Chen, C.C.H, Zhang, H, Kim, A.D, Howard, A, Sheldrick, G.M, Mariano-Dunnaway, D, Herzberg, O. | | 登録日 | 2002-06-26 | | 公開日 | 2002-11-20 | | 最終更新日 | 2025-03-26 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Degradation Pathway of the Phosphonate Ciliatine: Crystal Structure of 2-Aminoethylphosphonate Transaminase
Biochemistry, 41, 2002
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9GKF
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5FMD
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1M6D
 | | Crystal structure of human cathepsin F | | 分子名称: | 4-MORPHOLIN-4-YL-PIPERIDINE-1-CARBOXYLIC ACID [1-(3-BENZENESULFONYL-1-PROPYL-ALLYLCARBAMOYL)-2-PHENYLETHYL]-AMIDE, Cathepsin F | | 著者 | Somoza, J.R, Palmer, J.T, Ho, J.D. | | 登録日 | 2002-07-15 | | 公開日 | 2003-07-15 | | 最終更新日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators
J.Mol.Biol., 322, 2002
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1M70
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9GOP
 | | Crystal structure of CDK2-cyclin E1 bound by compound 30 | | 分子名称: | 2-[(2~{S})-1-[9-ethyl-6-[(2-methyl-5-methylsulfonyl-pyrazol-3-yl)amino]purin-2-yl]-4,4-bis(fluoranyl)pyrrolidin-2-yl]propan-2-ol, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1 | | 著者 | Collie, G.W. | | 登録日 | 2024-09-05 | | 公開日 | 2025-09-10 | | 最終更新日 | 2025-09-24 | | 実験手法 | X-RAY DIFFRACTION (2.158 Å) | | 主引用文献 | Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.
J.Med.Chem., 68, 2025
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7S7H
 | | Complex structure of Methane monooxygenase hydroxylase and regulatory subunit DBL2 | | 分子名称: | 1,2-ETHANEDIOL, FE (III) ION, Methane monooxygenase beta chain, ... | | 著者 | Johns, J.C, Banerjee, R, Semonis, M.M, Shi, K, Aihara, H, Lipscomb, J.D. | | 登録日 | 2021-09-16 | | 公開日 | 2021-12-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | X-ray Crystal Structures of Methane Monooxygenase Hydroxylase Complexes with Variants of Its Regulatory Component: Correlations with Altered Reaction Cycle Dynamics.
Biochemistry, 61, 2022
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9GMP
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1M8G
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2PAQ
 | | Crystal structure of the 5'-deoxynucleotidase YfbR | | 分子名称: | 5'-deoxynucleotidase YfbR | | 著者 | Zimmerman, M.D, Chruszcz, M, Cymborowski, M, Kudritska, M, Minor, W, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2007-03-27 | | 公開日 | 2007-04-10 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli.
J.Mol.Biol., 378, 2008
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1M8O
 | | Platelet integrin alfaIIb-beta3 cytoplasmic domain | | 分子名称: | platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain | | 著者 | Vinogradova, O, Velyvis, A, Velyviene, A, Hu, B, Haas, T, Plow, E.F, Qin, J. | | 登録日 | 2002-07-25 | | 公開日 | 2002-09-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Structural mechanism of integrin alfaiib beta3
"Inside-out" Activation as regulated by its cytoplasmic face.
Cell(Cambridge,Mass.), 110, 2002
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7S02
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1M9Y
 | | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A,G89A Complex. | | 分子名称: | Cyclophilin A, HIV-1 Capsid | | 著者 | Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. | | 登録日 | 2002-07-30 | | 公開日 | 2003-05-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of cyclophilin A
Nat.Struct.Biol., 10, 2003
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7S6Q
 | | Complex structure of Methane monooxygenase hydroxylase and regulatory subunit DBL2 | | 分子名称: | 1,2-ETHANEDIOL, BENZOIC ACID, FE (III) ION, ... | | 著者 | Johns, J.C, Banerjee, R, Semonis, M.M, Shi, K, Aihara, H, Lipscomb, J.D. | | 登録日 | 2021-09-14 | | 公開日 | 2021-12-29 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | X-ray Crystal Structures of Methane Monooxygenase Hydroxylase Complexes with Variants of Its Regulatory Component: Correlations with Altered Reaction Cycle Dynamics.
Biochemistry, 61, 2022
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1M3W
 | | Crystal Structure of a Molecular Maquette Scaffold | | 分子名称: | H10H24, MERCURY (II) ION | | 著者 | Huang, S.S, Gibney, B.R, Stayrook, S.E, Dutton, P.L, Lewis, M. | | 登録日 | 2002-07-01 | | 公開日 | 2003-02-18 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | X-ray Structure of a Maquette Scaffold
J.Mol.Biol., 326, 2003
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9GKK
 | | BetP heterotrimeric complex | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, CARDIOLIPIN, DODECYL-BETA-D-MALTOSIDE, ... | | 著者 | Urbansky, K, Fu, L, Madej, M.G, Ziegler, C. | | 登録日 | 2024-08-25 | | 公開日 | 2025-09-10 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Structure of Glycine betaine transporter BetP heterotrimeric complex
To be published
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1M45
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5F9O
 | | Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.09 in complex with HIV-1 clade A/E 93TH057 gp120 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CH235.09 Light chain, ... | | 著者 | Joyce, M.G, Mascola, J.R, Kwong, P.D. | | 登録日 | 2015-12-10 | | 公開日 | 2016-03-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Cell, 165, 2016
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