5JLJ
 
 | | Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 | | 分子名称: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... | | 著者 | Fung, H.Y, Chook, Y.M. | | 登録日 | 2016-04-27 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
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4AHK
 | | K54E - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN, D(-)-TARTARIC ACID | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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4AHD
 | | Q12L - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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4AHN
 | | R121H - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN, CHLORIDE ION | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.977 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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4A55
 | | Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 | | 分子名称: | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PIK-108 | | 著者 | Hon, W.-C, Berndt, A, Williams, R.L. | | 登録日 | 2011-10-24 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases.
Oncogene, 31, 2012
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4AHJ
 | | I46V - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN, D(-)-TARTARIC ACID | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.032 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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4AHF
 | | K17E - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | 1,2-ETHANEDIOL, ANGIOGENIN, SULFATE ION | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.115 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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4ALD
 | | HUMAN MUSCLE FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE COMPLEXED WITH FRUCTOSE 1,6-BISPHOSPHATE | | 分子名称: | 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), FRUCTOSE-BISPHOSPHATE ALDOLASE | | 著者 | Dalby, A.R, Dauter, Z, Littlechild, J.A. | | 登録日 | 1998-07-26 | | 公開日 | 1999-03-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications.
Protein Sci., 8, 1999
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2RD0
 | | Structure of a human p110alpha/p85alpha complex | | 分子名称: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Huang, C, Gabelli, S.B, Amzel, L.M. | | 登録日 | 2007-09-20 | | 公開日 | 2007-12-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Science, 318, 2007
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4AHM
 | | V113I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN, L(+)-TARTARIC ACID | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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8QVU
 | | Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex | | 分子名称: | (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | | 著者 | Wijaya, A.J, Zollman, D, Farnaby, W, Ciulli, A. | | 登録日 | 2023-10-18 | | 公開日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Targeting cancer with small molecule pan-KRAS degraders
Biorxiv, 2023
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4AHI
 | | K40I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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8QYQ
 | | Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Mavacamten | | 分子名称: | 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. | | 登録日 | 2023-10-26 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Biorxiv, 2023
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8QYP
 | | Beta-cardiac myosin motor domain in the pre-powerstroke state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-7, ... | | 著者 | Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. | | 登録日 | 2023-10-26 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.759 Å) | | 主引用文献 | Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Biorxiv, 2023
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8QYU
 | | Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Omecamtiv mecarbil | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, FORMIC ACID, ... | | 著者 | Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. | | 登録日 | 2023-10-26 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Biorxiv, 2023
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8QYR
 | | Beta-cardiac myosin motor domain in the pre-powerstroke state complexed to Mavacamten | | 分子名称: | 1,2-ETHANEDIOL, 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. | | 登録日 | 2023-10-26 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction.
Biorxiv, 2023
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4AHE
 | | K17I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN, L(+)-TARTARIC ACID | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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4AHH
 | | R31K - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis | | 分子名称: | ANGIOGENIN, L(+)-TARTARIC ACID | | 著者 | Thiyagarajan, N, Ferguson, R, Saha, S, Pham, T, Subramanian, V, Acharya, K.R. | | 登録日 | 2012-02-06 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.498 Å) | | 主引用文献 | Structural and Molecular Insights Into the Mechanism of Action of Human Angiogenin-Als Variants in Neurons.
Nat.Commun., 3, 2012
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2RGN
 | | Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | | 著者 | Shankaranarayanan, A, Nance, M.R, Tesmer, J.J.G. | | 登録日 | 2007-10-04 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science, 318, 2007
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5QU8
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5QU3
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5QUA
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5QU1
 | | Crystal Structure of the monomeric human Nck SH3.1 domain, triclinic, 1.08A | | 分子名称: | Cytoplasmic protein NCK1, SULFATE ION | | 著者 | Burger, D, Ruf, A, Benz, J, Schlatter, D, Rudolph, M.G. | | 登録日 | 2019-12-13 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.
J.Biol.Chem., 295, 2020
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5QU5
 | | Domain Swap in the first SH3 domain of human Nck1 | | 分子名称: | Cytoplasmic protein NCK1 | | 著者 | Burger, D, Ruf, A, Benz, J, Schlatter, D, Rudolph, M.G. | | 登録日 | 2019-12-13 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | | 主引用文献 | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.
J.Biol.Chem., 295, 2020
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5QU2
 | | Crystal Structure of human Nck SH3.1 in complex with peptide PPPVPNPDY | | 分子名称: | ACE-PRO-PRO-PRO-VAL-PRO-ASN-PRO-ASP-TYR-NH2, Cytoplasmic protein NCK1, SULFATE ION | | 著者 | Rudolph, M.G. | | 登録日 | 2019-12-13 | | 公開日 | 2020-02-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | | 主引用文献 | Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.
J.Biol.Chem., 295, 2020
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