8GWF
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![BU of 8gwf by Molmil](/molmil-images/mine/8gwf) | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | 著者 | Yan, L.Y, Huang, Y.C, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2023-01-11 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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7THM
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![BU of 7thm by Molmil](/molmil-images/mine/7thm) | SARS-CoV-2 nsp12/7/8 complex with a native N-terminus nsp9 | 分子名称: | MANGANESE (II) ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Osinski, A, Tagliabracci, V.S, Chen, Z, Li, Y. | 登録日 | 2022-01-11 | 公開日 | 2022-03-16 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | The mechanism of RNA capping by SARS-CoV-2. Nature, 609, 2022
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3G86
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![BU of 3g86 by Molmil](/molmil-images/mine/3g86) | Hepatitis C virus polymerase NS5B (BK 1-570) with thiazine inhibitor | 分子名称: | N-{3-[6-fluoro-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, NICKEL (II) ION, RNA-directed RNA polymerase | 著者 | Harris, S.F, Ghate, M. | 登録日 | 2009-02-11 | 公開日 | 2009-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones Bioorg.Med.Chem.Lett., 19, 2009
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3CO9
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![BU of 3co9 by Molmil](/molmil-images/mine/3co9) | Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | 分子名称: | N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7 -yl}methanesulfonamide, RNA-directed RNA polymerase | 著者 | Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. | 登録日 | 2008-03-27 | 公開日 | 2009-02-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
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7ELB
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![BU of 7elb by Molmil](/molmil-images/mine/7elb) | Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Peng, R, Xu, X, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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8GWO
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![BU of 8gwo by Molmil](/molmil-images/mine/8gwo) | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWG
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![BU of 8gwg by Molmil](/molmil-images/mine/8gwg) | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWI
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![BU of 8gwi by Molmil](/molmil-images/mine/8gwi) | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Helicase, Non-structural protein 7, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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8GWN
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![BU of 8gwn by Molmil](/molmil-images/mine/8gwn) | A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527 | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yan, L.M, Huang, Y.C, Ge, J, Liu, Z.Y, Gao, Y, Rao, Z.H, Lou, Z.Y. | 登録日 | 2022-09-17 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. Cell, 185, 2022
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4MZ4
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![BU of 4mz4 by Molmil](/molmil-images/mine/4mz4) | Discovery of an Irreversible HCV NS5B Polymerase Inhibitor | 分子名称: | 1-[(2-chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | 著者 | Zeng, Q, Anilkumar, G.N, Rosenblum, S.B, Huang, H.-C, Lesburg, C.A, Jiang, Y, Selyutin, O, Chan, T.-Y, Bennett, F, Chen, K.X, Venkatraman, S, Sannigrahi, M, Velazquez, F, Duca, J.S, Gavalas, S, Huang, Y, Pu, H, Wang, L, Pinto, P, Vibulbhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Li, C, Hesk, D, Gesell, J, Sorota, S, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | 登録日 | 2013-09-29 | 公開日 | 2013-12-11 | 最終更新日 | 2013-12-18 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Discovery of an irreversible HCV NS5B polymerase inhibitor. Bioorg.Med.Chem.Lett., 23, 2013
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3U4R
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![BU of 3u4r by Molmil](/molmil-images/mine/3u4r) | Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides | 分子名称: | 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-N-({3-[(methylsulfonyl)amino]phenyl}sulfonyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, RNA-directed RNA polymerase | 著者 | Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannagrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | 登録日 | 2011-10-10 | 公開日 | 2011-12-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
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3GNW
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![BU of 3gnw by Molmil](/molmil-images/mine/3gnw) | HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c | 分子名称: | (11S)-11-[4-(benzyloxy)-2-fluorophenyl]-3,3-dimethyl-10-[(6-methylpyridin-2-yl)carbonyl]-2,3,4,5,10,11-hexahydrothiopyrano[3,2-b][1,5]benzodiazepin-6-ol 1,1-dioxide, CHLORIDE ION, RNA-directed RNA polymerase | 著者 | Nyanguile, O, De Bondt, H. | 登録日 | 2009-03-18 | 公開日 | 2009-10-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase. J.Med.Chem., 52, 2009
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3U4O
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![BU of 3u4o by Molmil](/molmil-images/mine/3u4o) | Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides | 分子名称: | 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | 著者 | Anilkumar, G.N, Selyutin, O, Rosenblum, S.B, Zeng, Q, Jiang, Y, Chan, T.-Y, Pu, H, Wang, L, Bennett, F, Chen, K.X, Lesburg, C.A, Duca, J.S, Gavalas, S, Huang, Y, Pinto, P, Sannigrahi, M, Velazquez, F, Venkataraman, S, Vilbubhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Huang, H.-C, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | 登録日 | 2011-10-10 | 公開日 | 2011-12-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22, 2012
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1YVZ
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![BU of 1yvz by Molmil](/molmil-images/mine/1yvz) | Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor | 分子名称: | 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | 登録日 | 2005-02-16 | 公開日 | 2005-03-22 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005
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1YVX
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![BU of 1yvx by Molmil](/molmil-images/mine/1yvx) | Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor | 分子名称: | 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION | 著者 | Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. | 登録日 | 2005-02-16 | 公開日 | 2005-03-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J.Biol.Chem., 280, 2005
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4IZ0
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![BU of 4iz0 by Molmil](/molmil-images/mine/4iz0) | Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide | 分子名称: | 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide, RNA-directed RNA polymerase | 著者 | Coulombe, R. | 登録日 | 2013-01-29 | 公開日 | 2013-04-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4IH7
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3I5K
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![BU of 3i5k by Molmil](/molmil-images/mine/3i5k) | Crystal structure of the NS5B polymerase from Hepatitis C Virus (HCV) strain JFH1 | 分子名称: | PHOSPHATE ION, RNA-directed RNA polymerase | 著者 | Simister, P.C, Schmitt, M, Lohmann, V, Bressanelli, S. | 登録日 | 2009-07-05 | 公開日 | 2009-09-22 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and functional analysis of hepatitis C virus strain JFH1 polymerase J.Virol., 83, 2009
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8SQJ
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![BU of 8sqj by Molmil](/molmil-images/mine/8sqj) | SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode | 分子名称: | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine, MAGNESIUM ION, Non-structural protein 7, ... | 著者 | Small, G.I, Darst, S.A, Campbell, E.A. | 登録日 | 2023-05-04 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain. Mol.Cell, 83, 2023
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3D5M
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![BU of 3d5m by Molmil](/molmil-images/mine/3d5m) | Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | 分子名称: | N-({3-[(5S)-5-tert-butyl-1-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzis othiazol-7-yl}methyl)methanesulfonamide, RNA-directed RNA polymerase | 著者 | Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. | 登録日 | 2008-05-16 | 公開日 | 2009-05-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
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6YA5
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![BU of 6ya5 by Molmil](/molmil-images/mine/6ya5) | 2009 H1N1 PA Endonuclease in complex with LU2 | 分子名称: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Radilova, K, Brynda, J. | 登録日 | 2020-03-11 | 公開日 | 2020-09-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. Eur.J.Med.Chem., 208, 2020
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3WI0
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![BU of 3wi0 by Molmil](/molmil-images/mine/3wi0) | |
3WI1
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1GX5
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6YEM
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![BU of 6yem by Molmil](/molmil-images/mine/6yem) | H1N1 2009 PA Endonuclease in complex with Quambalarine B | 分子名称: | 3,5,6,8-tetrakis(oxidanyl)-2-pentanoyl-naphthalene-1,4-dione, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Radilova, K, Brynda, J. | 登録日 | 2020-03-25 | 公開日 | 2020-09-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors. Eur.J.Med.Chem., 208, 2020
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