3LAK

Crystal structure of HIV-1 reverse transcriptase in complex with N1-heterocycle pyrimidinedione non-nucleoside inhibitor

Summary for 3LAK

• Entry DOI: 10.2210/pdb3lak/pdb
• Related: 3LAL 3LAM 3LAN
• Descriptor: HIV Reverse transcriptase, 3-({3-[(2-amino-6-fluoropyridin-4-yl)methyl]-5-(1-methylethyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl}carbonyl)-5-methylbenzonitrile, SULFATE ION, ... (5 entities in total)
• Functional Keywords: hiv, reverse transcriptase, rt, nnrti, transferase
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• Total number of polymer chains: 2
• Total formula weight: 129967.03

Authors

Lansdon, E.B.,Mitchell, M.L. (deposition date: 2010-01-06, release date: 2010-02-23, Last modification date: 2023-09-06)

• Primary citation: Mitchell, M.L.,Son, J.C.,Lee, I.Y.,Lee, C.K.,Kim, H.S.,Guo, H.,Wang, J.,Hayes, J.,Wang, M.,Paul, A.,Lansdon, E.B.,Chen, J.M.,Eisenberg, G.,Geleziunas, R.,Xu, L.,Kim, C.U.; N1-Heterocyclic pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.; Bioorg.Med.Chem.Lett., 20:1585-1588, 2010; PubMed: 20137928; DOI: 10.1016/j.bmcl.2010.01.086

Experimental method

X-RAY DIFFRACTION (2.3 Å)