6DUH

Crystal structure of HIV-1 reverse transcriptase Y181I mutant in complex with non-nucleoside inhibitor 25a

Summary for 6DUH

• Entry DOI: 10.2210/pdb6duh/pdb
• Related: 6C0N
• Descriptor: p66 RT, p51 RT, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... (8 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase, non-nucleoside inhibitor, replication
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10); More
• Total number of polymer chains: 2
• Total formula weight: 117162.27

Authors

Yang, Y.,Nguyen, L.A.,Smithline, Z.B.,Steitz, T.A. (deposition date: 2018-06-20, release date: 2018-08-01, Last modification date: 2023-10-11)

• Primary citation: Yang, Y.,Kang, D.,Nguyen, L.A.,Smithline, Z.B.,Pannecouque, C.,Zhan, P.,Liu, X.,Steitz, T.A.; Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.; Elife, 7:-, 2018; PubMed: 30044217; DOI: 10.7554/eLife.36340

Experimental method

X-RAY DIFFRACTION (2.003 Å)