PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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1KAZ	70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT 分子名称: 70KD HEAT SHOCK COGNATE PROTEIN, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 O'Brien, M.C, Flaherty, K.M, Mckay, D.B. 登録日 1996-04-15 公開日 1996-11-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis. J.Biol.Chem., 271, 1996
1KAX	70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71M MUTANT 分子名称: 70KD HEAT SHOCK COGNATE PROTEIN, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 O'Brien, M.C, Flaherty, K.M, Mckay, D.B. 登録日 1996-04-15 公開日 1996-11-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis. J.Biol.Chem., 271, 1996
1KAY	70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71A MUTANT 分子名称: 70KD HEAT SHOCK COGNATE PROTEIN, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 O'Brien, M.C, Flaherty, K.M, Mckay, D.B. 登録日 1996-04-15 公開日 1996-11-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis. J.Biol.Chem., 271, 1996
3HSC	THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 7OKD PROTEIN, MAGNESIUM ION, ... 著者 Flaherty, K.M, Deluca-Flaherty, C.R, Mckay, D.B. 登録日 1995-03-24 公開日 1995-07-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature, 346, 1990
3IUC	Crystal structure of the human 70kDa heat shock protein 5 (BiP/GRP78) ATPase domain in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70kDa protein 5 (Glucose-regulated protein, ... 著者 Wisniewska, M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotyenova, T, Kotzch, A, Kraulis, P, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) 登録日 2009-08-31 公開日 2009-09-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Plos One, 5, 2010
3JXU	Crystal structure of the human 70kDa heat shock protein 1A (Hsp70-1) ATPase domain in complex with ADP and inorganic phosphate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1, MAGNESIUM ION, ... 著者 Wisniewska, M.M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kraulis, P, Kotenyova, T, Kotzsch, A, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC) 登録日 2009-09-21 公開日 2009-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Plos One, 5, 2010
6CZ1	Crystal structure of ATPase domain of Human GRP78 bound to Ver155008 分子名称: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION 著者 Antoshchenko, T, Chen, Y, Hughes, S, Park, H. 登録日 2018-04-07 公開日 2019-04-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Crystallographic selection of adenosine analogs that fit the mold of the active site of human GRP78 and beyond To be Published
3I33	Crystal structure of the human 70kDa heat shock protein 2 (Hsp70-2) ATPase domain in complex with ADP and inorganic phosphate 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock-related 70 kDa protein 2, ... 著者 Wisniewska, M, Karlberg, T, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Kotzsch, A, Nielsen, T.K, Nordlund, P, Nyman, T, Moche, M, Persson, C, Roos, A.K, Sagemark, J, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Weigelt, J, Welin, M, Schueler, H, Structural Genomics Consortium (SGC) 登録日 2009-06-30 公開日 2009-07-21 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78 Plos One, 5, 2010
4R5K	Crystal structure of the DnaK C-terminus (Dnak-SBD-B) 分子名称: CALCIUM ION, Chaperone protein DnaK, SULFATE ION 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7469 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
3ATV	Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ... 著者 Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-01-13 公開日 2011-12-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
3ATU	Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state 分子名称: 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ... 著者 Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-01-13 公開日 2011-12-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
4R5J	Crystal structure of the DnaK C-terminus (Dnak-SBD-A) 分子名称: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.361 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5L	Crystal structure of the DnaK C-terminus (Dnak-SBD-C) 分子名称: CALCIUM ION, Chaperone protein DnaK, PHOSPHATE ION, ... 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9701 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
3AY9	Crystal structure of human Hsp70 NBD in the ADP-, Mg ion-, and K ion-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... 著者 Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2011-05-03 公開日 2011-12-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
4R5I	Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG 分子名称: Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ... 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9702 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5G	Crystal structure of the DnaK C-terminus with the inhibitor PET-16 分子名称: Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium 著者 Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. 登録日 2014-08-21 公開日 2014-09-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.4501 Å) 主引用文献 Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
3C7N	Structure of the Hsp110:Hsc70 Nucleotide Exchange Complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CHLORIDE ION, ... 著者 Schuermann, J.P, Jiang, J, Hart, P.J, Sousa, R. 登録日 2008-02-07 公開日 2008-05-27 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.115 Å) 主引用文献 Structure of the Hsp110:Hsc70 nucleotide exchange machine Mol.Cell, 31, 2008
6DFO	Crystal structure of human GRP78 in complex with 8-bromoadenosine 分子名称: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-05-15 公開日 2019-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Crystal structure of human GRP78 in complex with 8-bromoadenosine To be Published
6DO2	Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine 分子名称: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-06-08 公開日 2019-06-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine To Be Published
6EOC	Crystal structure of AMPylated GRP78 in apo form (Crystal form 2) 分子名称: 78 kDa glucose-regulated protein, CITRATE ANION, SULFATE ION 著者 Yan, Y, Preissler, S, Ron, D, Read, R.J. 登録日 2017-10-09 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017
6DFM	Crystal structure of human GRP78 in complex with 8-aminoadenosine 分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-05-15 公開日 2019-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Crystal structure of human GRP78 in complex with 8-aminoadenosine To be Published
6DWS	Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 分子名称: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION 著者 Chen, Y, Antoshchenko, T, Smil, D, Zepeda, C, Huang, Y, Park, H.W. 登録日 2018-06-27 公開日 2019-07-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol To Be Published
6EOF	Crystal structure of AMPylated GRP78 in ADP state 分子名称: 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Yan, Y, Preissler, S, Read, R.J, Ron, D. 登録日 2017-10-09 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017
6EOE	Crystal structure of AMPylated GRP78 with nucleotide 分子名称: 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ... 著者 Yan, Y, Preissler, S, Ron, D, Read, R.J. 登録日 2017-10-09 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017
6EOB	Crystal structure of AMPylated GRP78 in apo form (Crystal form 1) 分子名称: 78 kDa glucose-regulated protein, PHOSPHATE ION 著者 Yan, Y, Preissler, S, Ron, D, Read, R.J. 登録日 2017-10-09 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017

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