4YSI
 
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4Z96
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4Z97
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5VSB
 | | Structure of DUB complex | | 分子名称: | 7-chloro-3-{[4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl]methyl}quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2017-05-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
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5VS6
 | | Structure of DUB complex | | 分子名称: | ACETATE ION, GLYCEROL, N-[3-({4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl}methyl)-4-oxo-3,4-dihydroquinazolin-7-yl]-3-(4-methylpiperazin-1-yl)propanamide, ... | | 著者 | Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2017-05-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
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5VSK
 | | Structure of DUB complex | | 分子名称: | 7-chloro-3-({4-hydroxy-1-[(3S)-3-phenylbutanoyl]piperidin-4-yl}methyl)quinazolin-4(3H)-one, Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION | | 著者 | Seo, H.-Y, Dhe-Paganon, S. | | 登録日 | 2017-05-11 | | 公開日 | 2017-12-20 | | 最終更新日 | 2018-01-03 | | 実験手法 | X-RAY DIFFRACTION (3.33 Å) | | 主引用文献 | Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol, 24, 2017
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2F1Z
 | | Crystal structure of HAUSP | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Hu, M, Gu, L, Jeffrey, P.D, Shi, Y. | | 登録日 | 2005-11-15 | | 公開日 | 2006-02-07 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
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5VBT
 | | Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor | | 分子名称: | UBH04 | | 著者 | DONG, A, DONG, X, LIU, L, GUO, Y, LI, Y, ZHANG, W, WALKER, J.R, SIDHU, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC) | | 登録日 | 2017-03-30 | | 公開日 | 2017-06-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Crystal structure of a highly specific and potent USP7 ubiquitin variant inhibitor
to be published
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4JJQ
 | | Crystal structure of usp7-ntd with an e2 enzyme | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin-conjugating enzyme E2 E1 | | 著者 | Saridakis, V. | | 登録日 | 2013-03-08 | | 公開日 | 2013-05-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.
J. Biol. Chem., 288, 2013
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5GG4
 | | Crystal structure of USP7 with RNF169 peptide | | 分子名称: | Peptide from E3 ubiquitin-protein ligase RNF169, Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Jiang, Y, Gong, Q. | | 登録日 | 2016-06-15 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Dual-utility NLS drives RNF169-dependent DNA damage responses.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4HK2
 | | U7Ub25.2540 | | 分子名称: | SULFATE ION, Ubiquitin | | 著者 | Murray, J.M, Rouge, L. | | 登録日 | 2012-10-14 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
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4HJK
 | | U7Ub7 Disulfide variant | | 分子名称: | PHOSPHATE ION, Ubiquitin | | 著者 | Murray, J.M, Rouge, L. | | 登録日 | 2012-10-12 | | 公開日 | 2012-11-21 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.784 Å) | | 主引用文献 | Potent and selective inhibitors of USP7/HAUSP activity by protein conformational stabilization
to be published
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6P5L
 | | Crystal Structure of Ubl123 with an EZH2 peptide | | 分子名称: | PRO-ARG-LYS-LYS-LYS-ARG-LYS-HIS, Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Saridakis, V. | | 登録日 | 2019-05-30 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.296 Å) | | 主引用文献 | Structural Basis of the Interaction Between Ubiquitin Specific Protease 7 and Enhancer of Zeste Homolog 2.
J.Mol.Biol., 432, 2020
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6GDJ
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1NB8
 | | Structure of the catalytic domain of USP7 (HAUSP) | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7 | | 著者 | Hu, M, Li, P, Li, M, Li, W, Yao, T, Wu, J.-W, Gu, W, Cohen, R.E, Shi, Y. | | 登録日 | 2002-12-02 | | 公開日 | 2003-01-07 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
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5TOG
 | | Room temperature structure of ubiquitin variant u7ub25.2540 | | 分子名称: | Polyubiquitin-B, SULFATE ION | | 著者 | Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. | | 登録日 | 2016-10-17 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure, 25, 2017
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5TOF
 | | Room temperature structure of ubiquitin variant u7ub25 | | 分子名称: | Polyubiquitin-B, SULFATE ION | | 著者 | Biel, J.T, Thompson, M.C, Cunningham, C.N, Corn, J.E, Fraser, J.S. | | 登録日 | 2016-10-17 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin.
Structure, 25, 2017
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4Y2E
 | | Crystal structure of the catalytic domain of human dual-specificity phosphatase 7 (C232S) | | 分子名称: | Dual specificity protein phosphatase 7, PHOSPHATE ION | | 著者 | Lountos, G.T, Austin, B.P, Tropea, J.E, Waugh, D.S. | | 登録日 | 2015-02-09 | | 公開日 | 2015-06-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Structure of human dual-specificity phosphatase 7, a potential cancer drug target.
Acta Crystallogr.,Sect.F, 71, 2015
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8ITP
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8ITN
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8QH5
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2XXN
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6GHA
 | | USP15 catalytic domain structure | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15, ZINC ION | | 著者 | Ward, S.J, Gratton, H.E, Caulton, S.G, Emsley, J, Dreveny, I. | | 登録日 | 2018-05-06 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
J. Biol. Chem., 293, 2018
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6GH9
 | | USP15 catalytic domain in complex with small molecule | | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, DIMETHYL SULFOXIDE, Ubiquitin carboxyl-terminal hydrolase 15, ... | | 著者 | Ward, S.J, Gratton, H.E, Caulton, S.G, Emsley, J, Dreveny, I. | | 登録日 | 2018-05-06 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel.
J. Biol. Chem., 293, 2018
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8HJE
 | | Vismodegib binds to the catalytical domain of human Ubiquitin-Specific Protease 28 | | 分子名称: | 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, Ubiquitin carboxyl-terminal hydrolase 28 | | 著者 | Shi, L, Wang, H, Xu, Z, Xiong, B, Zhang, N. | | 登録日 | 2022-11-23 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structure-based discovery of potent USP28 inhibitors derived from Vismodegib.
Eur.J.Med.Chem., 254, 2023
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