5JTW
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4M76
| Integrin I domain of complement receptor 3 in complex with C3d | 分子名称: | Complement C3, Integrin alpha-M, NICKEL (II) ION | 著者 | Bajic, G, Yatime, L, Vorup-Jensen, T, Andersen, G.R. | 登録日 | 2013-08-12 | 公開日 | 2013-10-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.804 Å) | 主引用文献 | Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3. Proc.Natl.Acad.Sci.USA, 110, 2013
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5JPN
| Structure of human complement C4 rebuilt using iMDFF | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A, ... | 著者 | Croll, T.I, Andersen, G.R. | 登録日 | 2016-05-03 | 公開日 | 2016-08-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
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6TAV
| Crystal structure of endopeptidase-induced alpha2-macroglobulin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Gomis-Ruth, F.X, Duquerroy, S, Trapani, S, Marrero, A, Goulas, T, Guevara, T, Andersen, G.A, Sottrup-Jensen, L, Navaza, J. | 登録日 | 2019-10-30 | 公開日 | 2021-05-12 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Cryo-EM structures shows the mechanistic basis of pan-peptidase inhibition by human alpha2-macroglobulin Proc.Natl.Acad.Sci.USA, 2022
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4ZIQ
| Crystal structure of trypsin activated alpha-2-macroglobulin from Escherichia coli. | 分子名称: | CHLORIDE ION, GLYCEROL, Uncharacterized lipoprotein YfhM | 著者 | Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, X.F. | 登録日 | 2015-04-28 | 公開日 | 2015-06-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition. Proc.Natl.Acad.Sci.USA, 112, 2015
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6RUV
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4ZH1
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6H03
| OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... | 著者 | Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. | 登録日 | 2018-07-06 | 公開日 | 2018-12-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
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6H04
| Closed conformation of the Membrane Attack Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5,Complement C5, ... | 著者 | Menny, A, Serna, M, Boyd, C.M, Gardner, S, Joseph, A.P, Topf, M, Bubeck, D. | 登録日 | 2018-07-06 | 公開日 | 2018-12-19 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (5.6 Å) | 主引用文献 | CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers. Nat Commun, 9, 2018
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4ZIU
| Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning the residues from domain MG7 to the C-terminus. | 分子名称: | GLYCEROL, NICKEL (II) ION, Uncharacterized lipoprotein YfhM | 著者 | Garcia-Ferrer, I, Arede, P, Gomez-Blanco, J, Luque, D, Duquerroy, S, Caston, J.R, Goulas, T, Gomis-Ruth, X.F. | 登録日 | 2015-04-28 | 公開日 | 2015-06-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition. Proc.Natl.Acad.Sci.USA, 112, 2015
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4ONT
| Ternary host recognition complex of complement factor H, C3d, and sialic acid | 分子名称: | Complement C3d fragment, Complement factor H, GLYCEROL, ... | 著者 | Blaum, B.S, Stehle, T.S. | 登録日 | 2014-01-29 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural basis for sialic acid-mediated self-recognition by complement factor H. Nat.Chem.Biol., 11, 2015
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3L5N
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3KLS
| Structure of complement C5 in complex with SSL7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | 著者 | Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R. | 登録日 | 2009-11-09 | 公開日 | 2009-11-24 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus Proc.Natl.Acad.Sci.USA, 107, 2010
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3KM9
| Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | 著者 | Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R. | 登録日 | 2009-11-10 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus Proc.Natl.Acad.Sci.USA, 107, 2010
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6RU5
| human complement C3 in complex with the hC3Nb1 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jensen, R.K, Andersen, G.R. | 登録日 | 2019-05-27 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol, 10, 2019
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6RQJ
| Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5, Complement inhibitor, ... | 著者 | Reichhardt, M.P, Johnson, S, Lea, S.M. | 登録日 | 2019-05-15 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | An inhibitor of complement C5 provides structural insights into activation. Proc.Natl.Acad.Sci.USA, 117, 2020
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6RUR
| Structure of the SCIN stabilized C3bBb convertase bound to properdin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, ... | 著者 | Pedersen, D.V, Gadeberg, T.A.F, Andersen, G.R. | 登録日 | 2019-05-29 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol, 10, 2019
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3OXU
| Complement components factor H CCP19-20 and C3d in complex | 分子名称: | Complement C3, GLYCEROL, HF protein | 著者 | Morgan, H.P, Schmidt, C.Q, Guariento, M, Gillespie, D, Herbert, A.P, Mertens, H, Blaum, B.S, Svergun, D, Johansson, C.M, Uhrin, D, Barlow, P.N, Hannan, J.P. | 登録日 | 2010-09-22 | 公開日 | 2011-02-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for engagement by complement factor H of C3b on a self surface. Nat.Struct.Mol.Biol., 18, 2011
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4RTD
| Escherichia coli alpha-2-macroglobulin activated by porcine elastase | 分子名称: | Uncharacterized lipoprotein YfhM | 著者 | Fyfe, C.D, Grinter, R, Roszak, A.W, Josts, I, Cogdell, R.J, Walker, D. | 登録日 | 2014-11-14 | 公開日 | 2015-07-15 | 最終更新日 | 2015-07-29 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structure of protease-cleaved Escherichia coli alpha-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallogr.,Sect.D, 71, 2015
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3PVM
| Structure of Complement C5 in Complex with CVF | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, Complement C5 | 著者 | Laursen, N.S, Andersen, K.R, Braren, I, Sottrup-Jensen, L, Spillner, E, Andersen, G.R. | 登録日 | 2010-12-07 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. Embo J., 30, 2011
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4U4J
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4U48
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4U59
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3OED
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3PRX
| Structure of Complement C5 in Complex with CVF and SSL7 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cobra venom factor, ... | 著者 | Laursen, N.S, Andersen, G.R, Sottrup-Jensen, L, Andersen, K.R, Spillner, E, Braren, I. | 登録日 | 2010-11-30 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | 主引用文献 | Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex. Embo J., 30, 2011
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