PDB: 435 件ウェブページステータス検索Chemie searchBIRD

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6CJR	Candida albicans Hsp90 nucleotide binding domain in complex with SNX-2112 分子名称: 1,2-ETHANEDIOL, 4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide, Heat shock protein 90 homolog 著者 Kirkpatrick, M.G, Pizarro, J.C. 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
6CJJ	Candida albicans Hsp90 nucleotide binding domain in complex with ADP 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 90 homolog, ... 著者 Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
6CJS	Candida albicans Hsp90 nucleotide binding domain in complex with AUY922 分子名称: 1,2-ETHANEDIOL, 5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE, Heat shock protein 90 homolog 著者 Kirkpatrick, M.G, Pizarro, J.C. 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
6CJP	Candida albicans Hsp90 nucleotide binding domain in complex with radicicol 分子名称: (1aR,2Z,4E,6E,14R,15aR)-9,11-dihydroxy-6-{[(4-methoxyphenyl)methoxy]imino}-14-methyl-1a,6,7,14,15,15a-hexahydro-12H-oxireno[e][2]benzoxacyclotetradecin-12-one, Heat shock protein 90 homolog 著者 Nation, C, Pizarro, J.C. 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
1R62	Crystal structure of the C-terminal Domain of the Two-Component System Transmitter Protein NRII (NtrB) 分子名称: Nitrogen regulation protein NR(II) 著者 Song, Y, Peisach, D, Pioszak, A.A, Xu, Z, Ninfa, A.J. 登録日 2003-10-14 公開日 2004-06-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of the C-terminal Domain of the Two-Component System Transmitter Protein Nitrogen Regulator II (NRII; NtrB), Regulator of Nitrogen Assimilation in Escherichia coli. Biochemistry, 43, 2004
6CJI	Candida albicans Hsp90 nucleotide binding domain 分子名称: 1,2-ETHANEDIOL, Heat shock protein 90 homolog 著者 Hutchinson, A, Loppnau, P, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, STRUCTURAL GENOMICS CONSORTIUM, S.G.C, Pizarro, J.C, Structural Genomics Consortium (SGC) 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
6CJL	Candida albicans Hsp90 nucleotide binding domain in complex with radicicol 分子名称: Heat shock protein 90 homolog, MAGNESIUM ION, RADICICOL 著者 Nation, C, Pizarro, J.C. 登録日 2018-02-26 公開日 2019-01-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.6972 Å) 主引用文献 Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus. Nat Commun, 10, 2019
8H70	Crystal structure of the catalytic ATP-binding domain of the PhoR sensor histidine kinase from Vibrio cholera 分子名称: DI(HYDROXYETHYL)ETHER, Phosphate regulon sensor protein PhoR 著者 Jia, R, Zhao, W, Hattori, M. 登録日 2022-10-18 公開日 2023-02-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structure of the catalytic ATP-binding domain of the PhoR sensor histidine kinase. Proteins, 91, 2023
5IDM	Bifunctional histidine kinase CckA (domain, CA) in complex with c-di-GMP and AMPPNP/Mg2+ 分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Cell cycle histidine kinase CckA, MAGNESIUM ION, ... 著者 Dubey, B.N, Schirmer, T. 登録日 2016-02-24 公開日 2016-10-05 最終更新日 2022-09-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Sci Adv, 2, 2016
6BLK	Mycobacterial sensor histidine kinase MprB 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Signal transduction histidine-protein kinase/phosphatase mprB 著者 Li, J, Korotkova, N, Korotkov, K.V. 登録日 2017-11-10 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.552 Å) 主引用文献 Mycobacterial sensor histidine kinase MprB to be published
1S14	Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit 分子名称: NOVOBIOCIN, Topoisomerase IV subunit B 著者 Wei, Y, Gross, C.H. 登録日 2004-01-05 公開日 2004-05-04 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase. Antimicrob.Agents Chemother., 48, 2004
4XCJ	N-terminal domain of Hsp90 from Dictyostelium discoideum in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock cognate 90 kDa protein, MAGNESIUM ION 著者 Raman, S, Suguna, K. 登録日 2014-12-18 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4XDM	N-terminal domain of Hsp90 from Dictyostelium discoideum in complex with Geldanamycin 分子名称: DI(HYDROXYETHYL)ETHER, GELDANAMYCIN, Heat shock cognate 90 kDa protein 著者 Raman, S, Suguna, K. 登録日 2014-12-19 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4XE2	N-terminal domain of Hsp90 from Dictyostelium discoideum in complex with peptide 分子名称: Heat shock cognate 90 kDa protein 著者 Raman, S, Suguna, K. 登録日 2014-12-22 公開日 2015-12-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.199 Å) 主引用文献 First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90. Sci Rep, 5, 2015
6KZX	Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative 分子名称: 3-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid, DNA gyrase subunit B 著者 Mima, M, Takeuchi, T, Ushiyama, F. 登録日 2019-09-25 公開日 2020-05-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. Acs Omega, 5, 2020
4XKA	N-terminal domain of Hsp90 from Dictyostelium discoideum in hexagonal form with glycerol 分子名称: GLYCEROL, Heat shock cognate 90 kDa protein, TRIS(HYDROXYETHYL)AMINOMETHANE 著者 Raman, S, Suguna, K. 登録日 2015-01-10 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4XD8	N-terminal domain of Hsp90 from Dictyostelium discoideum in complex with ANP 分子名称: Heat shock cognate 90 kDa protein, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Raman, S, Suguna, K. 登録日 2014-12-19 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
4XKK	Crystal structure of N-terminal domain of Hsp90 from Dictyostelium discoideum 分子名称: Heat shock cognate 90 kDa protein 著者 Raman, S, Suguna, K. 登録日 2015-01-12 公開日 2015-01-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Heat shock protein 90 regulates development in Dictyostelium discoideum J. Mol. Biol., 383, 2008
6L01	Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative 分子名称: 2-[3-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]phenyl]ethanoic acid, DNA gyrase subunit B 著者 Mima, M, Takeuchi, T, Ushiyama, F. 登録日 2019-09-25 公開日 2020-05-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. Acs Omega, 5, 2020
4XKO	N-terminal domain of Hsp90 from Dictyostelium discoideum in hexagonal form with PEG 分子名称: DI(HYDROXYETHYL)ETHER, Heat shock cognate 90 kDa protein, TRIS(HYDROXYETHYL)AMINOMETHANE 著者 Raman, S, Suguna, K. 登録日 2015-01-12 公開日 2015-12-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.455 Å) 主引用文献 First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90 Sci Rep, 5, 2015
6KZZ	Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative 分子名称: 4-[[8-(methylamino)-2-oxidanylidene-1~{H}-quinolin-3-yl]carbonylamino]benzoic acid, DNA gyrase subunit B 著者 Mima, M, Takeuchi, T, Ushiyama, F. 登録日 2019-09-25 公開日 2020-05-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. Acs Omega, 5, 2020
6KZV	Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative 分子名称: DNA gyrase subunit B, ~{N}-[2-[[cyclohexyl(methyl)amino]methyl]phenyl]-2-oxidanylidene-1~{H}-quinoline-3-carboxamide 著者 Mima, M, Ushiyama, F. 登録日 2019-09-25 公開日 2020-05-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation. Acs Omega, 5, 2020
6M1J	The DNA Gyrase B ATP binding domain of PSEUDOMONAS AERUGINOSA in complex with compound 12x 分子名称: 1-[5-[6-fluoranyl-8-(methylamino)-4-[3-(trifluoromethyl)pyrazol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]pyrimidin-2-yl]cyclopropane-1-carboxylic acid, DIMETHYL SULFOXIDE, DNA gyrase subunit B, ... 著者 Xu, Z.H, Zhou, Z. 登録日 2020-02-26 公開日 2020-09-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV. J.Med.Chem., 63, 2020
4P8O	S. aureus gyrase bound to an aminobenzimidazole urea inhibitor 分子名称: 1-ethyl-3-[5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzimidazol-2-yl]urea, DNA gyrase subunit B 著者 Jacobs, M.D. 登録日 2014-03-31 公開日 2014-10-29 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability. J.Med.Chem., 57, 2014
4PL9	Structure of the catalytic domain of ETR1 from Arabidopsis thaliana 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ... 著者 Panneerselvam, S, Mueller-Dieckmann, J. 登録日 2014-05-16 公開日 2014-12-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Model of the Cytosolic Domain of the Plant Ethylene Receptor 1 (ETR1). J.Biol.Chem., 290, 2015

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