3E3H
 
 | | Crystal structure of the OP hydrolase mutant from Brevundimonas diminuta | | 分子名称: | COBALT (II) ION, DIETHYL 4-METHYLBENZYLPHOSPHONATE, Parathion hydrolase | | 著者 | Li, P, Reeves, T.E, Grimsley, J.K, Wild, J.R. | | 登録日 | 2008-08-07 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities.
Protein Eng.Des.Sel., 21, 2008
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3A3X
 | | Structure of OpdA mutant (G60A/A80V/R118Q/K185R/Q206P/D208G/I260T/G273S) | | 分子名称: | COBALT (II) ION, Phosphotriesterase | | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | | 登録日 | 2009-06-23 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
Proc.Natl.Acad.Sci.USA, 2009
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1P6C
 | | crystal structure of phosphotriesterase triple mutant H254G/H257W/L303T complexed with diisopropylmethylphosphonate | | 分子名称: | DIETHYL 4-METHYLBENZYLPHOSPHONATE, METHYLPHOSPHONIC ACID DIISOPROPYL ESTER, Parathion hydrolase, ... | | 著者 | Hill, C.M, Li, W, Thoden, J.B, Holden, H.M, Raushel, F.M. | | 登録日 | 2003-04-29 | | 公開日 | 2003-09-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
J.Am.Chem.Soc., 125, 2003
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1PTA
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3C86
 | | OpdA from agrobacterium radiobacter with bound product diethyl thiophosphate from crystal soaking with tetraethyl dithiopyrophosphate- 1.8 A | | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, FE (II) ION, ... | | 著者 | Ollis, D.L, Jackson, C.J, Foo, J.L, Kim, H.K, Carr, P.D, Liu, J.W, Salem, G. | | 登録日 | 2008-02-10 | | 公開日 | 2008-02-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
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3MSR
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2O4M
 | | Structure of Phosphotriesterase mutant I106G/F132G/H257Y | | 分子名称: | ACETIC ACID, CACODYLATE ION, GLYCEROL, ... | | 著者 | Kim, J, Ramagopal, U.A, Tsai, P, Raushel, F.M, Almo, S.C. | | 登録日 | 2006-12-04 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Structure of Phosphotriesterase mutant I106G/F132G/H257Y
To be Published
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2OB3
 | | Structure of Phosphotriesterase mutant H257Y/L303T | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Parathion hydrolase, ZINC ION | | 著者 | Kim, J, Ramagopal, U.A, Tsai, P, Raushel, F.M, Almo, S.C. | | 登録日 | 2006-12-18 | | 公開日 | 2007-01-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | | 主引用文献 | Structure of Phosphotriesterase mutant H257Y/L303T
To be Published
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2O4Q
 | | Structure of Phosphotriesterase mutant G60A | | 分子名称: | CACODYLATE ION, Parathion hydrolase, ZINC ION | | 著者 | Kim, J, Ramagopal, U.A, Tsai, P.C, Raushel, F.M, Almo, S.C. | | 登録日 | 2006-12-04 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of diethyl phosphate bound to the binuclear metal center of phosphotriesterase.
Biochemistry, 47, 2008
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2OQL
 | | Structure of Phosphotriesterase mutant H254Q/H257F | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Parathion hydrolase, ... | | 著者 | Kim, J, Tsai, P, Raushel, F.M, Almo, S.C. | | 登録日 | 2007-01-31 | | 公開日 | 2008-02-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of PTE mutant H254Q/H257F
To be Published
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3OJG
 | | Structure of an inactive lactonase from Geobacillus kaustophilus with bound N-butyryl-DL-homoserine lactone | | 分子名称: | FE (III) ION, N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide, Phosphotriesterase, ... | | 著者 | Xue, B, Chow, J.Y, Tung, A, Robinson, R.C. | | 登録日 | 2010-08-22 | | 公開日 | 2010-10-27 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Directed evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily
J.Biol.Chem., 285, 2010
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3OQE
 | | Structure of OpdA mutant Y257F | | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, Phosphotriesterase | | 著者 | Ely, F, Guddat, L.W, Ollis, D.L, Schenk, G. | | 登録日 | 2010-09-02 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis.
Biochem.J., 432, 2010
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3OVG
 | | The crystal structure of an amidohydrolase from Mycoplasma synoviae with Zn ion bound | | 分子名称: | PHOSPHATE ION, ZINC ION, amidohydrolase | | 著者 | Zhang, Z, Kumaran, D, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2010-09-16 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.059 Å) | | 主引用文献 | The crystal structure of an amidohydrolase from Mycoplasma synoviae with Zn ion bound
To be Published
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3OOD
 | | Structure of OpdA Y257F mutant soaked with diethyl 4-methoxyphenyl phosphate for 20 hours. | | 分子名称: | COBALT (II) ION, DIETHYL 4-METHOXYPHENYL PHOSPHATE, Phosphotriesterase | | 著者 | Ely, F, Guddat, L.W, Ollis, D.L, Schenk, G. | | 登録日 | 2010-08-31 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis.
Biochem.J., 432, 2010
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3ORW
 | | Crystal structure of thermophilic phosphotriesterase from Geobacillus kaustophilus HTA426 | | 分子名称: | COBALT (II) ION, Phosphotriesterase | | 著者 | Zheng, B.S, Yu, S.S, Zhang, Y, Lou, Z.Y, Feng, Y. | | 登録日 | 2010-09-07 | | 公開日 | 2011-09-21 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of thermophilic phosphotriesterase from Geobacillus kaustophilus HTA426
To be Published
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2R1L
 | | OpdA from Agrobacterium radiobacter with bound diethyl thiophosphate from crystal soaking with the compound- 1.95 A | | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, FE (II) ION, ... | | 著者 | Ollis, D.L, Jackson, C.J, Foo, J.L, Kim, H.K, Carr, P.D, Liu, J.W, Salem, G. | | 登録日 | 2007-08-23 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
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2R1N
 | | OpdA from Agrobacterium radiobacter with bound slow substrate diethyl 4-methoxyphenyl phosphate (20h)- 1.7 A | | 分子名称: | COBALT (II) ION, DIETHYL 4-METHOXYPHENYL PHOSPHATE, FE (II) ION, ... | | 著者 | Ollis, D.L, Jackson, C.J, Foo, J.L, Kim, H.K, Carr, P.D, Liu, J.W, Salem, G. | | 登録日 | 2007-08-23 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
J.Mol.Biol., 375, 2008
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4XAZ
 | | Cycles of destabilization and repair underlie evolutionary transitions in enzymes | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase variant PTE-R18, ZINC ION | | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | 登録日 | 2014-12-16 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD4
 | | Phosphotriesterase variant E2b | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R3, ... | | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | 登録日 | 2014-12-19 | | 公開日 | 2015-12-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XAG
 | | Cycles of destabilization and repair underlie the evolution of new enzyme function | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R6, ... | | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | 登録日 | 2014-12-14 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD3
 | | Phosphotriesterase variant E3 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E1, ... | | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | 登録日 | 2014-12-19 | | 公開日 | 2015-12-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD6
 | | Phosphotriesterase Variant E2a | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E2, ... | | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | 登録日 | 2014-12-19 | | 公開日 | 2015-12-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XD5
 | | Phosphotriesterase variant R2 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R2, ... | | 著者 | Campbell, E, Kaltenbach, M, Tokuriki, N, Jackson, C.J. | | 登録日 | 2014-12-19 | | 公開日 | 2015-12-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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4XAF
 | | Cycles of destabilization and repair underlie evolutionary transitions in enzymes | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R1, ... | | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | | 登録日 | 2014-12-14 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function.
Nat.Chem.Biol., 12, 2016
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3UR5
 | | Crystal Structure of PTE mutant K185R/I274N | | 分子名称: | COBALT (II) ION, DIETHYL HYDROGEN PHOSPHATE, Parathion hydrolase | | 著者 | Tsai, P, Fox, N.G, Li, Y, Barondeau, D.P, Raushel, F.M. | | 登録日 | 2011-11-21 | | 公開日 | 2012-08-01 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.
Biochemistry, 51, 2012
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