1P6C

crystal structure of phosphotriesterase triple mutant H254G/H257W/L303T complexed with diisopropylmethylphosphonate

Summary for 1P6C
Related1P6B
DescriptorParathion hydrolase, ZINC ION, DIETHYL 4-METHYLBENZYLPHOSPHONATE, ... (5 entities in total)
Functional Keywordsmetalloenzyme, tim barrel, nerve agent, hydrolase
Biological sourceFlavobacterium sp.
Cellular locationCell membrane ; Peripheral membrane protein : P0A433
Total number of polymer chains2
Total formula weight73767.13
Authors
Hill, C.M.,Li, W.,Thoden, J.B.,Holden, H.M.,Raushel, F.M. (deposition date: 2003-04-29, release date: 2003-09-16, Last modification date: 2017-10-11)
Primary citationHill, C.M.,Holden, H.M.,Li, W.S.,Raushel, F.M.,Thoden, J.B.
Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
J.Am.Chem.Soc., 125:8990-8991, 2003
PubMed: 15369336
DOI: 110.1021/ja0358798
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation
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PDB entries from 2021-06-16