PDB: 256 件ウェブページステータス検索Chemie searchBIRD

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5J5D	Crystal structure of Dihydrodipicolinate Synthase from Mycobacterium tuberculosis in complex with alpha-ketopimelic acid 分子名称: 2-oxoheptanedioic acid, 4-hydroxy-tetrahydrodipicolinate synthase, SODIUM ION 著者 Navratna, V, Gopal, B. 登録日 2016-04-02 公開日 2016-08-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues Sci Rep, 6, 2016
4DPQ	The structure of dihydrodipicolinate synthase 2 from Arabidopsis thaliana in complex with (S)-lysine 分子名称: Dihydrodipicolinate synthase 2, chloroplastic, LYSINE, ... 著者 Griffin, M.D.W, Billakanti, J.M, Gerrard, J.A, Dobson, R.C.J, Pearce, F.G. 登録日 2012-02-14 公開日 2012-07-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana Plos One, 7, 2012
5CZJ	Crystal structure of HypD, a 1-pyrroline-4-hydroxy-2-carboxylate deaminase from Sinorhizobium meliloti 分子名称: Dihydrodipicolinate synthase 著者 Stogios, P.J, Xu, X, Savchenko, A. 登録日 2015-07-31 公開日 2016-02-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 l-Hydroxyproline and d-Proline Catabolism in Sinorhizobium meliloti. J.Bacteriol., 198, 2016
5AFD	Native structure of N-acetylneuramininate lyase (sialic acid aldolase) from Aliivibrio salmonicida 分子名称: 1,2-ETHANEDIOL, GLYCEROL, N-ACETYLNEURAMINATE LYASE 著者 Gurung, M.K, Altermark, B, Rader, I.L.U, Helland, R, Smalas, A.O. 登録日 2015-01-21 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Features and structure of a cold active N-acetylneuraminate lyase. Plos One, 14, 2019
5KZE	N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus 分子名称: GLYCEROL, N-acetylneuraminate lyase, SULFATE ION 著者 North, R.A, Watson, A.J.A, Pearce, F.G, Muscroft-Taylor, A.C, Friemann, R, Fairbanks, A.J, Dobson, R.C.J. 登録日 2016-07-25 公開日 2017-01-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus. FEBS Lett., 590, 2016
5KTL	Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria Anabaena variabilis. 分子名称: 4-hydroxy-tetrahydrodipicolinate synthase, MANGANESE (II) ION 著者 Christensen, J.B, Panjikar, S, Perugini, M. 登録日 2016-07-11 公開日 2016-11-30 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structure and Function of Cyanobacterial DHDPS and DHDPR. Sci Rep, 6, 2016
4EOU	Crystal structure of E. coli dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site 分子名称: Dihydrodipicolinate synthase, GLYCEROL, POTASSIUM ION 著者 Boughton, B.A, Dobson, R.C.J, Hutton, C.A. 登録日 2012-04-15 公開日 2012-04-25 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: Unambiguous resolution of the stereochemistry of the condensation product. Proteins, 80, 2012
5KZD	N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus with bound sialic acid alditol 分子名称: (2~{S},4~{S},5~{R},6~{R},7~{S},8~{R})-5-acetamido-2,4,6,7,8,9-hexakis(oxidanyl)nonanoic acid, N-acetylneuraminate lyase 著者 North, R.A, Watson, A.J.A, Pearce, F.G, Muscroft-Taylor, A.C, Friemann, R, Fairbanks, A.J, Dobson, R.C.J. 登録日 2016-07-25 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.334 Å) 主引用文献 Structure and inhibition of N-acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus. FEBS Lett., 590, 2016
6G3Z	Sulfolobus sulfataricus 2-keto-3-deoxygluconate (KDG) aldolase complex with D-KDPG 分子名称: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase, 2-keto 3 deoxy 6 phospho gluconate, ISOPROPYL ALCOHOL 著者 Crennell, S.J. 登録日 2018-03-26 公開日 2018-06-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Insights into the Substrate Specificity of Archaeal Entner-Doudoroff Aldolases: The Structures of Picrophilus torridus 2-Keto-3-deoxygluconate Aldolase and Sulfolobus solfataricus 2-Keto-3-deoxy-6-phosphogluconate Aldolase in Complex with 2-Keto-3-deoxy-6-phosphogluconate. Biochemistry, 57, 2018
6GT8	Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase Y132V,T157C variant 分子名称: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase, 3-DEOXY-D-ARABINO-HEXONIC ACID 著者 Crennell, S.J, Danson, M.J, Royer, S. 登録日 2018-06-15 公開日 2019-06-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase Y132V,T157C variant To Be Published
6H2S	Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase T157V/D181Q/A198L variant, pyruvate complex 分子名称: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Crennell, S.J, Danson, M.J, Royer, S. 登録日 2018-07-16 公開日 2019-07-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase T157V/D181Q/A198L variant To Be Published
5C54	Crystal structure of a novel N-acetylneuraminic acid lyase from Corynebacterium glutamicum 分子名称: Dihydrodipicolinate synthase/N-acetylneuraminate lyase, GLYCEROL 著者 Shen, Y, Zhou, J, Xie, J. 登録日 2015-06-19 公開日 2016-06-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Crystal structure of a novel N-acetylneuraminic acid lyase from Corynebacterium glutamicum To Be Published
2NUY	2-keto-3-deoxygluconate aldolase from Sulfolobus acidocaldarius in complex with pyruvate 分子名称: 2-keto-3-deoxygluconate/2-keto-3-deoxy-6-phospho gluconate aldolase, MAGNESIUM ION, PYRUVIC ACID 著者 van Eerde, A, Dijkstra, B.W. 登録日 2006-11-10 公開日 2007-04-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases Biochem.J., 403, 2007
2NUX	2-keto-3-deoxygluconate aldolase from Sulfolobus acidocaldarius, native structure in p6522 at 2.5 A resolution 分子名称: 2-keto-3-deoxygluconate/2-keto-3-deoxy-6-phospho gluconate aldolase, MAGNESIUM ION 著者 van Eerde, A, Dijkstra, B.W. 登録日 2006-11-10 公開日 2007-04-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases Biochem.J., 403, 2007
2OJP	The crystal structure of a dimeric mutant of Dihydrodipicolinate synthase from E.coli- DHDPS-L197Y 分子名称: Dihydrodipicolinate synthase, GLYCEROL 著者 Griffin, M.D.W, Dobson, R.C.J, Antonio, L, Perugini, M.A, Jameson, G.B, Gerrard, J.A. 登録日 2007-01-13 公開日 2008-01-01 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Evolution of quaternary structure in a homotetrameric enzyme. J.Mol.Biol., 380, 2008
2NUW	2-keto-3-deoxygluconate aldolase from Sulfolobus acidocaldarius, native structure at 1.8 A resolution 分子名称: 2-keto-3-deoxygluconate/2-keto-3-deoxy-6-phospho gluconate aldolase, MAGNESIUM ION 著者 van Eerde, A, Dijkstra, B.W. 登録日 2006-11-10 公開日 2007-04-10 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases Biochem.J., 403, 2007
5F1U	biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from Campylobacter jejuni 分子名称: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... 著者 Conly, C.J.T, Palmer, D.R.J, Sanders, D.A.R. 登録日 2015-11-30 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Biomimetic Design Results in a Potent Allosteric Inhibitor of Dihydrodipicolinate Synthase from Campylobacter jejuni. J.Am.Chem.Soc., 138, 2016
7LBD	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59K mutant with pyruvate bound in the active site in C2221 space group 分子名称: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... 著者 Saran, S, Yazdi, M.M, Sanders, D.A.R. 登録日 2021-01-07 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Reversing the roles of a crucial hydrogen-bonding pair: a lysine-insensitive mutant of Campylobacter jejuni dihydrodipicolinate synthase, H59K, binds histidine in its allosteric site To Be Published
7LCF	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, with pyruvate bound in the active site and L-lysine bound at the allosteric site in C121 space group 分子名称: 4-hydroxy-tetrahydrodipicolinate synthase, LYSINE, MAGNESIUM ION 著者 Saran, S, Sanders, D.A.R. 登録日 2021-01-10 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 B-factors: L- lysine and R, R- bisLysine allosterically inhibit Cj. DHDPS Enzyme by decreasing its protein dynamics To Be Published
6UE0	Crystal structure of dihydrodipicolinate synthase from Klebsiella pneumoniae bound to pyruvate 分子名称: 4-hydroxy-tetrahydrodipicolinate synthase, CHLORIDE ION, SULFATE ION 著者 Impey, R.E, Lee, M, Hawkins, D.A, Sutton, J.M, Panjikar, S, Perugini, M.A, Soares da Costa, T.P. 登録日 2019-09-20 公開日 2020-02-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.892 Å) 主引用文献 Mis-annotations of a promising antibiotic target in high-priority gram-negative pathogens. Febs Lett., 594, 2020
7M06	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, Y110F mutant with R,R-bislysine bound at the allosteric site at 2.7 Angstrom 分子名称: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... 著者 Saran, S, Sanders, D.A.R. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 B-FACTOR ANALYSIS SUGGEST THAT L-LYSINE AND R, R-BISLYSINE ALLOSTERICALLY INHIBIT Cj.DHDPS ENZYME BY DECREASING PROTEIN DYNAMICS To Be Published
2A6L	Dihydrodipicolinate synthase (E. coli)- mutant R138H 分子名称: Dihydrodipicolinate synthase, POTASSIUM ION 著者 Dobson, R.C, Devenish, S.R, Turner, L.A, Clifford, V.R, Pearce, F.G, Jameson, G.B, Gerrard, J.A. 登録日 2005-07-03 公開日 2005-10-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Role of Arginine 138 in the Catalysis and Regulation of Escherichia coli Dihydrodipicolinate Synthase. Biochemistry, 44, 2005
6U01	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84D mutant with pyruvate bound in the active site 分子名称: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... 著者 Saran, S, Majdi Yazdi, M, Lehnert, L, Palmer, D.R.J, Sanders, D.A.R. 登録日 2019-08-13 公開日 2019-12-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase. J.Struct.Biol., 209, 2020
6TZU	Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84A mutant with pyruvate bound in the active site 分子名称: 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ACETATE ION, ... 著者 Saran, S, Majdi Yazdi, M, Lehnert, C, Palmer, D.R.J, Sanders, D.A.R. 登録日 2019-08-13 公開日 2019-12-04 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase. J.Struct.Biol., 209, 2020
2A6N	Dihydrodipicolinate synthase (E. coli)- mutant R138A 分子名称: Dihydrodipicolinate synthase, POTASSIUM ION 著者 Dobson, R.C, Devenish, S.R, Turner, L.A, Clifford, V.R, Pearce, F.G, Jameson, G.B, Gerrard, J.A. 登録日 2005-07-03 公開日 2005-10-18 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Role of Arginine 138 in the Catalysis and Regulation of Escherichia coli Dihydrodipicolinate Synthase. Biochemistry, 44, 2005

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