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7QI8	CRYSTAL STRUCTURE OF LYSYL-TRNA SYNTHETASE FROM Mycobacterium tuberculosis COMPLEXED WITH L-LYSINE AND INHIBITOR 分子名称: 2-azanyl-6-[(1~{S},7~{S})-2,2-bis(fluoranyl)-7-oxidanyl-cycloheptyl]-4-methoxy-7~{H}-pyrrolo[3,4-d]pyrimidin-5-one, LYSINE, Lysine--tRNA ligase 1 著者 Dawson, A, Robinson, D.A, Tamjar, J, Wyatt, P, Green, S. 登録日 2021-12-14 公開日 2022-10-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs. Nat Commun, 13, 2022
4PG3	Crystal structure of KRS complexed with inhibitor 分子名称: LYSINE, Lysine--tRNA ligase, cladosporin 著者 Sharma, A, Yogavel, M, Khan, S, Sharma, A, Belrhali, H. 登録日 2014-05-01 公開日 2014-07-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.696 Å) 主引用文献 Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin. J. Struct. Funct. Genomics, 15, 2014
4O2D	Crystal structure of aspartyl-tRNA synthetase from Mycobacterium smegmatis with bound aspartic acid 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ASPARTIC ACID, Aspartate--tRNA ligase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2013-12-17 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
8TC8	Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate 分子名称: 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
8TC7	Human asparaginyl-tRNA synthetase, apo form 分子名称: Asparagine--tRNA ligase, cytoplasmic, CHLORIDE ION, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
8TC9	Human asparaginyl-tRNA synthetase bound to OSM-S-106 分子名称: Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... 著者 Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. 登録日 2023-06-30 公開日 2024-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
4YCU	Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase 分子名称: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ... 著者 Fang, P, Wang, J, Guo, M. 登録日 2015-02-20 公開日 2015-06-10 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chem. Biol., 22, 2015
4RMF	Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target 分子名称: 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID 著者 Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K. 登録日 2014-10-21 公開日 2014-11-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target. Plos One, 9, 2014
6M0T	Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with L-lysine and Cladosporin derivative (CL-2) 分子名称: (3R)-3-[(R)-[(2R,6S)-6-methyloxan-2-yl]-oxidanyl-methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE, Lysine--tRNA ligase 著者 Babbar, P, Sharma, A, Manickam, Y. 登録日 2020-02-22 公開日 2021-04-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites. Acs Infect Dis., 7, 2021
4UP8	Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase apo form 分子名称: LYSINE--TRNA LIGASE 著者 Bonnefond, L, Nureki, O. 登録日 2014-06-14 公開日 2014-10-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.896 Å) 主引用文献 Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain. FEBS Lett., 588, 2014
3A5Z	Crystal structure of Escherichia coli GenX in complex with elongation factor P 分子名称: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Elongation factor P, Putative lysyl-tRNA synthetase 著者 Sumida, T, Yanagisawa, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-08-17 公開日 2010-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor P. Nat.Struct.Mol.Biol., 17, 2010
4UPA	Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with AMPPNP 分子名称: LYSINE--TRNA LIGASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Bonnefond, L, Nureki, O. 登録日 2014-06-14 公開日 2014-10-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain. FEBS Lett., 588, 2014
4UP9	Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, LYSINE--TRNA LIGASE 著者 Bonnefond, L, Nureki, O. 登録日 2014-06-14 公開日 2014-10-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.047 Å) 主引用文献 Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain. FEBS Lett., 588, 2014
6NS0	Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis complexed with L-lysine and Cladosporin 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-01-24 公開日 2019-02-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and Cladosporin to be published
4UP7	Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate 分子名称: ADENOSINE-5'-[LYSYL-PHOSPHATE], LYSINE--TRNA LIGASE 著者 Bonnefond, L, Nureki, O. 登録日 2014-06-14 公開日 2014-10-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.789 Å) 主引用文献 Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain. FEBS Lett., 588, 2014
6NRZ	Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis complexed with L-lysine and Adenosine 分子名称: 1,2-ETHANEDIOL, ADENOSINE, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-01-24 公開日 2019-02-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and Adenosine to be published
6O3F	Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and a difluoro cyclohexyl chromone ligand 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, LYSINE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-02-26 公開日 2019-03-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Chlamydia trachomatis with complexed with L-lysine and a difluoro cyclohexyl chromone ligand to be published
3A74	Lysyl-tRNA synthetase from Bacillus stearothermophilus complexed with Diadenosine Tetraphosphate (AP4A) 分子名称: 2,6-DIAMINO-HEXANOIC ACID AMIDE, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Lysyl-tRNA synthetase, ... 著者 Sakurama, H, Takita, T, Mikami, B, Itoh, T, Yasukawa, K, Inouye, K. 登録日 2009-09-13 公開日 2010-09-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Bacillus stearothermophilus in Complex with Diadenosine Tetraphosphate (AP4A): Insights into AP4A Synthesis Mechanisms and Implication for Recognition of Discriminator Base of tRNA^Lys To be Published
3BJU	Crystal Structure of tetrameric form of human lysyl-tRNA synthetase 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ... 著者 Guo, M, Yang, X.L, Schimmel, P. 登録日 2007-12-04 公開日 2008-02-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa, 105, 2008
6AQG	Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine and Cladosporin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, LYSINE, Lysine--tRNA ligase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-08-19 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine and Cladosporin to be published
6AQH	Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium thermoresistibile complexed with L-lysine and Cladosporin 分子名称: 1,2-ETHANEDIOL, LYSINE, Lysine--tRNA ligase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-08-19 公開日 2017-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium thermoresistibile complexed with L-lysine and Cladosporin to be published
6CHD	Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine 分子名称: 1,2-ETHANEDIOL, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, GLYCEROL, ... 著者 Dranow, D.M, Abendroth, J, Lorimer, D.D. 登録日 2018-02-22 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of Human Lysyl-tRNA Synthetase complexed with L-Lysylsulfamoyl Adenosine to be published
6BNI	Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and Adenosine 分子名称: 1,2-ETHANEDIOL, ADENOSINE, LYSINE, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-11-16 公開日 2018-02-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and Adenosine to be published
6C86	Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine 分子名称: 1,2-ETHANEDIOL, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-01-24 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine to be published
3M4P	Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS) in complex with asparaginyl-adenylate 分子名称: 4-AMINO-1,4-DIOXOBUTAN-2-AMINIUM ADENOSINE-5'-MONOPHOSPHATE, Asparaginyl-tRNA synthetase, putative, ... 著者 Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) 登録日 2010-03-11 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 X-ray crystal structure of asparaginyl-tRNA synthetase from the eukaryotic human pathogen Entamoeba histolytica. to be published

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