8SDY
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8JTS
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![BU of 8jts by Molmil](/molmil-images/mine/8jts) | hOCT1 in complex with metformin in outward open conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JU0
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![BU of 8ju0 by Molmil](/molmil-images/mine/8ju0) | hOCT1 in complex with spironolactone in inward facing occluded conformation | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-23 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTW
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![BU of 8jtw by Molmil](/molmil-images/mine/8jtw) | hOCT1 in complex with nb5660 in inward facing partially open 1 conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTX
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![BU of 8jtx by Molmil](/molmil-images/mine/8jtx) | hOCT1 in complex with nb5660 in inward facing fully open conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTZ
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![BU of 8jtz by Molmil](/molmil-images/mine/8jtz) | hOCT1 in complex with spironolactone in outward facing partially occluded conformation | 分子名称: | SPIRONOLACTONE, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTT
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![BU of 8jtt by Molmil](/molmil-images/mine/8jtt) | hOCT1 in complex with metformin in outward occluded conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTY
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![BU of 8jty by Molmil](/molmil-images/mine/8jty) | hOCT1 in complex with nb5660 in inward facing partially open 2 conformation | 分子名称: | Solute carrier family 22 member 1, nanobody 56 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8JTV
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![BU of 8jtv by Molmil](/molmil-images/mine/8jtv) | hOCT1 in complex with metformin in inward occluded conformation | 分子名称: | Metformin, Solute carrier family 22 member 1 | 著者 | Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X. | 登録日 | 2023-06-22 | 公開日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Structural insights into human organic cation transporter 1 transport and inhibition. Cell Discov, 10, 2024
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8UO9
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![BU of 8uo9 by Molmil](/molmil-images/mine/8uo9) | Structure of synaptic vesicle protein 2A in complex with a nanobody | 分子名称: | (4R)-1-{[(4S)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(4,4,4-trifluorobutyl)pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A. | 登録日 | 2023-10-19 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants. Nat.Struct.Mol.Biol., 2024
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8UOA
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![BU of 8uoa by Molmil](/molmil-images/mine/8uoa) | Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody, Synaptic vesicle glycoprotein 2A, ... | 著者 | Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A. | 登録日 | 2023-10-19 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants. Nat.Struct.Mol.Biol., 2024
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8UO8
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![BU of 8uo8 by Molmil](/molmil-images/mine/8uo8) | Structure of synaptic vesicle protein 2B with padsevonil | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[(4R)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], ... | 著者 | Martin, M.F, Mittal, A, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A. | 登録日 | 2023-10-19 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants. Nat.Struct.Mol.Biol., 2024
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8YF0
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8YF1
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8JLH
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![BU of 8jlh by Molmil](/molmil-images/mine/8jlh) | Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam | 分子名称: | (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yamagata, A. | 登録日 | 2023-06-02 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8JLC
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![BU of 8jlc by Molmil](/molmil-images/mine/8jlc) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam | 分子名称: | (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yamagata, A. | 登録日 | 2023-06-02 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8JLI
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![BU of 8jli by Molmil](/molmil-images/mine/8jli) | Cryo-EM structure of SV2A dimer in complex levetiracetam | 分子名称: | (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, Synaptic vesicle glycoprotein 2A | 著者 | Yamagata, A. | 登録日 | 2023-06-02 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8JLF
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![BU of 8jlf by Molmil](/molmil-images/mine/8jlf) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Botulinum neurotoxin, ... | 著者 | Yamagata, A. | 登録日 | 2023-06-02 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8K77
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![BU of 8k77 by Molmil](/molmil-images/mine/8k77) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam | 分子名称: | (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yamagata, A. | 登録日 | 2023-07-26 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8JS8
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![BU of 8js8 by Molmil](/molmil-images/mine/8js8) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam | 分子名称: | (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yamagata, A. | 登録日 | 2023-06-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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8JS9
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![BU of 8js9 by Molmil](/molmil-images/mine/8js9) | Cryo-EM structure of SV2A in complex with BoNT/A2 Hc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Botulinum neurotoxin, ... | 著者 | Yamagata, A. | 登録日 | 2023-06-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A. Nat Commun, 15, 2024
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