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8SDY
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BU of 8sdy by Molmil
Structure of rat organic anion transporter 1 (OAT1) in complex with para-aminohippuric acid (PAH)
分子名称: N-(4-aminobenzoyl)glycine, Solute carrier family 22 member 6
著者Dou, T, Jiang, J.
登録日2023-04-07
公開日2023-10-18
最終更新日2023-11-22
実験手法ELECTRON MICROSCOPY (2.79 Å)
主引用文献The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM.
Nat.Struct.Mol.Biol., 30, 2023
8JTS
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BU of 8jts by Molmil
hOCT1 in complex with metformin in outward open conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JU0
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BU of 8ju0 by Molmil
hOCT1 in complex with spironolactone in inward facing occluded conformation
分子名称: SPIRONOLACTONE, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-23
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTW
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BU of 8jtw by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 1 conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.23 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTX
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BU of 8jtx by Molmil
hOCT1 in complex with nb5660 in inward facing fully open conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTZ
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BU of 8jtz by Molmil
hOCT1 in complex with spironolactone in outward facing partially occluded conformation
分子名称: SPIRONOLACTONE, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTT
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BU of 8jtt by Molmil
hOCT1 in complex with metformin in outward occluded conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTY
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BU of 8jty by Molmil
hOCT1 in complex with nb5660 in inward facing partially open 2 conformation
分子名称: Solute carrier family 22 member 1, nanobody 56
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8JTV
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BU of 8jtv by Molmil
hOCT1 in complex with metformin in inward occluded conformation
分子名称: Metformin, Solute carrier family 22 member 1
著者Zhang, S, Zhu, A, Kong, F, Chen, J, Lan, B, He, G, Gao, K, Cheng, L, Yan, C, Chen, L, Liu, X.
登録日2023-06-22
公開日2024-03-27
実験手法ELECTRON MICROSCOPY (3.77 Å)
主引用文献Structural insights into human organic cation transporter 1 transport and inhibition.
Cell Discov, 10, 2024
8UO9
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BU of 8uo9 by Molmil
Structure of synaptic vesicle protein 2A in complex with a nanobody
分子名称: (4R)-1-{[(4S)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}-4-(4,4,4-trifluorobutyl)pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A.
登録日2023-10-19
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Nat.Struct.Mol.Biol., 2024
8UOA
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BU of 8uoa by Molmil
Structure of the synaptic vesicle protein 2A Luminal domain in complex with a nanobody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody, Synaptic vesicle glycoprotein 2A, ...
著者Mittal, A, Martin, M.F, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A.
登録日2023-10-19
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Nat.Struct.Mol.Biol., 2024
8UO8
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BU of 8uo8 by Molmil
Structure of synaptic vesicle protein 2B with padsevonil
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[(4R)-2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one, 1,2-DIDECANOYL-SN-GLYCERO-3-[PHOSPHO-L-SERINE], ...
著者Martin, M.F, Mittal, A, Levin, E, Adams, C, Yang, M, Ledecq, M, Horanyi, P.S, Coleman, J.A.
登録日2023-10-19
公開日2024-05-22
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants.
Nat.Struct.Mol.Biol., 2024
8YF0
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BU of 8yf0 by Molmil
Cryo-EM structure of human SV2A
分子名称: Synaptic vesicle glycoprotein 2A
著者Qu, Q, Liu, S, Zhou, Z.
登録日2024-02-23
公開日2024-06-12
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Cryo-EM structure of human SV2A
To Be Published
8YF1
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BU of 8yf1 by Molmil
Cryo-EM structure of human SV2A in complex with Brivaracetam
分子名称: (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, Synaptic vesicle glycoprotein 2A
著者Qu, Q, Liu, S, Zhou, Z.
登録日2024-02-23
公開日2024-06-12
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Cryo-EM structure of human SV2A in complex with Brivaracetam
To Be Published
8JLH
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BU of 8jlh by Molmil
Cryo-EM structure of SV2A dimer in complex with BoNT/A2 Hc and levetiracetam
分子名称: (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yamagata, A.
登録日2023-06-02
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8JLC
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BU of 8jlc by Molmil
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
分子名称: (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yamagata, A.
登録日2023-06-02
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8JLI
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BU of 8jli by Molmil
Cryo-EM structure of SV2A dimer in complex levetiracetam
分子名称: (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, Synaptic vesicle glycoprotein 2A
著者Yamagata, A.
登録日2023-06-02
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8JLF
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BU of 8jlf by Molmil
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Botulinum neurotoxin, ...
著者Yamagata, A.
登録日2023-06-02
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8K77
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BU of 8k77 by Molmil
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and brivaracetam
分子名称: (2S)-2-[(4R)-2-oxidanylidene-4-propyl-pyrrolidin-1-yl]butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yamagata, A.
登録日2023-07-26
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8JS8
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BU of 8js8 by Molmil
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc and levetiracetam
分子名称: (2S)-2-(2-oxidanylidenepyrrolidin-1-yl)butanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yamagata, A.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
8JS9
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BU of 8js9 by Molmil
Cryo-EM structure of SV2A in complex with BoNT/A2 Hc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Botulinum neurotoxin, ...
著者Yamagata, A.
登録日2023-06-19
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nat Commun, 15, 2024
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件を2024-08-14に公開中

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