8JS9

Cryo-EM structure of SV2A in complex with BoNT/A2 Hc

This is a non-PDB format compatible entry.

Summary for 8JS9

• Entry DOI: 10.2210/pdb8js9/pdb
• EMDB information: 36617
• Descriptor: Synaptic vesicle glycoprotein 2A, Botulinum neurotoxin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: synaptic vesicle, botulinum neurotoxin, epilepsy, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 134243.16

Authors

Yamagata, A. (deposition date: 2023-06-19, release date: 2024-05-01, Last modification date: 2024-05-08)

• Primary citation: Yamagata, A.,Ito, K.,Suzuki, T.,Dohmae, N.,Terada, T.,Shirouzu, M.; Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.; Nat Commun, 15:3027-3027, 2024; PubMed: 38637505; DOI: 10.1038/s41467-024-47322-4

Experimental method

ELECTRON MICROSCOPY (3.01 Å)