8JS9

Cryo-EM structure of SV2A in complex with BoNT/A2 Hc

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Synaptic vesicle glycoprotein 2A	polymer	750	83774.0	1	UniProt (Q7L0J3) Pfam (PF00083) In PDB	Homo sapiens (human)
2	B	Botulinum neurotoxin	polymer	426	49456.2	1	UniProt (D2KCK3) Pfam (PF07953) Pfam (PF07951) In PDB	Clostridium botulinum
3	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 2 - 742 (UniProt: Q7L0J3)

PDB	External Database	Details
Met -7	-	initiating methionine
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	133230.2
Branched	Number of molecules	1
	Total formula weight	570.5
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	134243.2

*Water molecules are not included.