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4P6Q
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The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs
分子名称: Msx2-interacting protein, SULFATE ION
著者Arieti, F, Gabus, C, Tambalo, M, Huet, T, Round, A, Thore, S.
登録日2014-03-25
公開日2014-05-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs.
Nucleic Acids Res., 42, 2014
2RT5
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BU of 2rt5 by Molmil
Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation
分子名称: Msx2-interacting protein, peptide from Silencing mediator of retinoic acid and thyroid hormone receptor
著者Mikami, S, Kanaba, T, Mishima, M.
登録日2013-04-22
公開日2013-12-04
最終更新日2022-08-24
実験手法SOLUTION NMR
主引用文献Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation.
Structure, 22, 2014
5TD7
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BU of 5td7 by Molmil
Crystal structure of histone deacetylase 10
分子名称: 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ...
著者Hai, Y, Shinsky, S.A, Porter, N.J, Christianson, D.W.
登録日2016-09-17
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.
Nat Commun, 8, 2017
8I60
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Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr
分子名称: ALA-ARG-KCR-SER-ALA-PRO, GLYCEROL, SULFATE ION, ...
著者Konuma, T, Zhou, M.-M.
登録日2023-01-26
公開日2023-07-26
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Mol.Cell, 83, 2023
2VCG
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Crystal structure of a HDAC-like protein HDAH from Bordetella sp. with the bound inhibitor ST-17
分子名称: CHLORIDE ION, GLYCEROL, HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE, ...
著者Dickmanns, A, Strasser, A, Ficner, R.
登録日2007-09-24
公開日2008-01-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Phenylalanine-Containing Hydroxamic Acids as Selective Inhibitors of Class Iib Histone Deacetylases (Hdacs).
Bioorg.Med.Chem., 16, 2008
6VNR
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Crystal Structure of Danio rerio Histone Deacetylase 6 Catalytic Domain 2 (CD2) Complexed with Bishydroxamic Acid Inhibitor
分子名称: 1,2-ETHANEDIOL, Hdac6 protein, N-hydroxy-1-{[4-(hydroxycarbamoyl)phenyl]methyl}-1H-indole-6-carboxamide, ...
著者Osko, J.D, Porter, N.J, Christianson, D.W.
登録日2020-01-29
公開日2020-05-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.94301319 Å)
主引用文献Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
Chemmedchem, 15, 2020
8P9I
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Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB462
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)benzamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
8P9K
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Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB503
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-azanyl-5-phenyl-phenyl)-4-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)benzamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
8P9J
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BU of 8p9j by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB500
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-5-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)pyridine-2-carboxamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
8P9F
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BU of 8p9f by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB161
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-[2-(2-azanyl-5-methyl-4-oxidanyl-phenyl)hydrazinyl]benzamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
8P9L
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BU of 8p9l by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB512
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-azanyl-5-phenyl-phenyl)-5-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)pyridine-2-carboxamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
8P9G
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BU of 8p9g by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB390
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-[(~{E})-(6-methyl-7-oxidanyl-1~{H}-indol-4-yl)diazenyl]benzamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
8P9H
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BU of 8p9h by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-2-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)quinoline-6-carboxamide
著者Balourdas, D.I, Bauer, N, Knapp, S, Joerger, A.C, Structural Genomics Consortium (SGC)
登録日2023-06-06
公開日2023-07-05
最終更新日2024-06-26
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization.
Acs Chem.Biol., 19, 2024
7Z1K
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BU of 7z1k by Molmil
Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5
分子名称: Msx2-interacting protein, SER-TYR-SER-PRO-THR-SEP
著者Appel, L, Grishkovskaya, I, Slade, D, Djinovic-Carugo, K.
登録日2022-02-24
公開日2022-12-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.
Nat Commun, 14, 2023
7AXR
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Crystal structure of BRD4(1) bound to the dual BET-HDAC inhibitor LSH24
分子名称: 4-acetyl-3-ethyl-N-(3-(3-(hydroxyamino)-3-oxopropyl)phenyl)-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4
著者Huegle, M.
登録日2020-11-10
公開日2021-10-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads.
J.Med.Chem., 64, 2021
8HLY
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BU of 8hly by Molmil
Crystal structure of SIRT3 in complex with H3K23la peptide
分子名称: (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, GLYCEROL, ...
著者Zhuming, F, Hao, Q.
登録日2022-12-01
公開日2023-09-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of SIRT3 as an eraser of H4K16la.
Iscience, 26, 2023
8HLW
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Crystal structure of SIRT3 in complex with H4K16la peptide
分子名称: (2S)-2-HYDROXYPROPANOIC ACID, Histone H4 residues 20-27, NAD-dependent protein deacetylase sirtuin-3, ...
著者Zhuming, F, Hao, Q.
登録日2022-12-01
公開日2023-09-27
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification of SIRT3 as an eraser of H4K16la.
Iscience, 26, 2023
1WQ6
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The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity
分子名称: AML1-ETO
著者Liu, Y, Cheney, M.D, Chruszcz, M, Lukasik, S.M, Hartman, K.L, Laue, T.M, Dauter, Z, Minor, W, Speck, N.A, Bushweller, J.H.
登録日2004-09-23
公開日2005-10-04
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity
Cancer Cell, 9, 2006
5KXF
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BU of 5kxf by Molmil
Crystal structure of the SPOC domain of the Arabidopsis flowering regulator FPA
分子名称: Flowering time control protein FPA
著者Zhang, Y, Tong, L.
登録日2016-07-20
公開日2016-10-12
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of the SPOC Domain of the Arabidopsis Flowering Regulator FPA.
Plos One, 11, 2016
5W5K
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Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with KV70
分子名称: 10-{[4-(hydroxycarbamoyl)phenyl]methyl}-5lambda~4~-pyrido[3,2-b][1,4]benzothiazin-10-ium, Histone deacetylase 6, POTASSIUM ION, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-06-15
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
J.Med.Chem., 62, 2019
4ZQA
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Crystal Structure of the Sds3 Dimerization Domain
分子名称: Sin3 histone deacetylase corepressor complex component SDS3
著者Chan, C.W, Mondragon, A, Clark, M, Radhakrishnan, I.
登録日2015-05-08
公開日2015-07-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
5FXY
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Structure of the human RBBP4:MTA1(464-546) complex
分子名称: HISTONE-BINDING PROTEIN RBBP4, METASTASIS-ASSOCIATED PROTEIN MTA1
著者Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R.
登録日2016-03-03
公開日2016-05-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Elife, 5, 2016
6V79
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Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with NF2376
分子名称: 1,2-ETHANEDIOL, 4-{[(2S)-3,3-dimethyl-2-(pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]methyl}-N-hydroxybenzamide, Hdac6 protein, ...
著者Osko, J.D, Christianson, D.W.
登録日2019-12-08
公開日2020-12-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.03951526 Å)
主引用文献Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.
J.Med.Chem., 64, 2021
6G16
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Structure of the human RBBP4:MTA1(464-546) complex showing loop exchange
分子名称: Histone-binding protein RBBP4, Metastasis-associated protein MTA1
著者Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R.
登録日2018-03-20
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The structure of the core NuRD repression complex provides insights into its interaction with chromatin.
Elife, 5, 2016
6HSK
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Crystal structure of a human HDAC8 L6 loop mutant complexed with Quisinostat
分子名称: 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, Histone deacetylase 8, POTASSIUM ION, ...
著者Marek, M, Shaik, T.B, Ramos-Morales, E, Romier, C.
登録日2018-10-01
公開日2018-10-31
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.096 Å)
主引用文献Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
J. Med. Chem., 61, 2018

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