7Z1K

Crystal structure of the SPOC domain of human SHARP (SPEN) in complex with RNA polymerase II CTD heptapeptide phosphorylated on Ser5

Summary for 7Z1K

Entry DOI	10.2210/pdb7z1k/pdb
Descriptor	Msx2-interacting protein, SER-TYR-SER-PRO-THR-SEP (3 entities in total)
Functional Keywords	human sharp, spoc domain, rna polymerase ii ctd heptapeptide, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	20452.40
Authors	Appel, L.,Grishkovskaya, I.,Slade, D.,Djinovic-Carugo, K. (deposition date: 2022-02-24, release date: 2022-12-07, Last modification date: 2024-02-07)
Primary citation	Appel, L.M.,Franke, V.,Benedum, J.,Grishkovskaya, I.,Strobl, X.,Polyansky, A.,Ammann, G.,Platzer, S.,Neudolt, A.,Wunder, A.,Walch, L.,Kaiser, S.,Zagrovic, B.,Djinovic-Carugo, K.,Akalin, A.,Slade, D. The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators. Nat Commun, 14:166-166, 2023 Cited by PubMed: 36631525 DOI: 10.1038/s41467-023-35853-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation