PDB: 115 件ウェブページステータス検索Chemie searchBIRD

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2MJ8	Solution structure of CDYL2 chromodomain 分子名称: Chromodomain Y-like protein 2 著者 Qin, S, Houliston, S, Arrowsmith, C.H, Edwards, A.M, Wu, H, Min, J, Structural Genomics Consortium (SGC) 登録日 2013-12-28 公開日 2014-04-23 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol, 27, 2020
4QUC	Crystal structure of chromodomain of Rhino 分子名称: RE36324p 著者 Li, S, Patel, D.J. 登録日 2014-07-10 公開日 2014-08-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.502 Å) 主引用文献 Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev., 28, 2014
4QUF	crystal structure of chromodomain of Rhino with H3K9me3 分子名称: H3(1-15)K9me3 peptide, RE36324p 著者 Li, S, Patel, D.J. 登録日 2014-07-10 公開日 2014-08-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev., 28, 2014
4U68	Crystal structure of Rhino chromodomain in complex with H3K9me3 分子名称: H3K9me3, Rhino 著者 Yu, B.W, Huang, Y. 登録日 2014-07-28 公開日 2015-08-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into Rhino-mediated germline piRNA cluster formation Cell Res., 25, 2015
4W5A	Complex structure of ATRX ADD bound to H3K9me3S10ph peptide 分子名称: Peptide from Histone H3.3, Transcriptional regulator ATRX, ZINC ION 著者 Zhao, D, Xiang, B, Li, H. 登録日 2014-08-17 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons Proc.Natl.Acad.Sci.USA, 112, 2015
4V2W	JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (16-35) 分子名称: CHLORIDE ION, GLYCEROL, HISTONE H3.1T, ... 著者 Chowdhury, R, Zafred, D, Schofield, C.J. 登録日 2014-10-15 公開日 2014-11-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates. Epigenetics, 9, 2014
4V2V	JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA 分子名称: CHLORIDE ION, HISTONE H3.1T, LYSINE-SPECIFIC DEMETHYLASE 4A, ... 著者 Chowdhury, R, Madden, S.K, Schofield, C.J. 登録日 2014-10-15 公開日 2014-11-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates. Epigenetics, 9, 2014
4YHP	Crystal structure of 309M3-B Fab in complex with H3K9me3 peptide 分子名称: Fab Heavy Chain, Fab Light Chain, H3K9me3 peptide 著者 Hattori, T, Dementieva, I.S, Montano, S.P, Koide, S. 登録日 2015-02-27 公開日 2016-02-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Proc.Natl.Acad.Sci.USA, 113, 2016
5F3I	Crystal structure of human KDM4A in complex with compound 54j 分子名称: 8-[4-[2-[4-[3,5-bis(chloranyl)phenyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F3E	Crystal structure of human KDM4A in complex with compound 54a 分子名称: 8-[4-[2-[4-(4-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.16 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F37	Crystal structure of human KDM4A in complex with compound 58 分子名称: 1,2-ETHANEDIOL, 3H-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F39	Crystal structure of human KDM4A in complex with compound 37 分子名称: 8-(1,3-thiazol-4-yl)-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, Lysine-specific demethylase 4A, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F2W	Crystal structure of human KDM4A in complex with compound 16 分子名称: 1,2-ETHANEDIOL, 2-(2-azanyl-1,3-thiazol-4-yl)pyridine-4-carboxamide, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F32	Crystal structure of human KDM4A in complex with compound 40 分子名称: 1,2-ETHANEDIOL, 8-(2-azanyl-1,3-thiazol-4-yl)-3~{H}-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F2S	Crystal structure of human KDM4A in complex with compound 15 分子名称: 1,2-ETHANEDIOL, 2-(2-azanyl-1,3-thiazol-4-yl)pyridine-4-carboxylic acid, CHLORIDE ION, ... 著者 Le Bihan, Y.-V, Dempster, S, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F3C	Crystal structure of human KDM4A in complex with compound 52d 分子名称: 8-[4-[2-[(4-fluorophenyl)methyl-methyl-amino]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F3G	Crystal structure of human KDM4A in complex with compound 53a 分子名称: 8-[4-[2-[4-[(4-chlorophenyl)methyl]piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Le Bihan, Y.-V, Westwood, I.M, van Montfort, R.L.M. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5FPL	Crystal structure of human JARID1B in complex with CCT363901 分子名称: 1,2-ETHANEDIOL, 8-[4-(2-azanylethyl)pyrazol-1-yl]-3H-pyrido[3,4-d]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... 著者 Srikannathasan, V, Yann-Vai, L.B, Nowak, R, Johansson, C, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Brennan, P, Huber, K, Oppermann, U. 登録日 2015-12-02 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 8-Substituted Pyrido[3,4-D]Pyrimidin-4(3H)-One Derivatives as Potent, Cell Permeable, Kdm4 (Jmjd2) and Kdm5 (Jarid1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F5C	Crystal Structure of human JMJD2D complexed with KDOPP7 分子名称: 1,2-ETHANEDIOL, 8-[[(phenylmethyl)amino]methyl]-1~{H}-pyrido[3,4-d]pyrimidin-4-one, Lysine-specific demethylase 4D, ... 著者 Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) 登録日 2015-12-04 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F5A	Crystal Structure of human JMJD2D complexed with KDOAM16 分子名称: 1,2-ETHANEDIOL, 2-[(furan-2-ylmethylamino)methyl]pyridine-4-carboxylic acid, Lysine-specific demethylase 4D, ... 著者 Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) 登録日 2015-12-04 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5F5I	Crystal Structure of human JMJD2A complexed with KDOOA011340 分子名称: 2-[[(phenylmethyl)amino]methyl]pyridine-4-carboxylic acid, Lysine-specific demethylase 4A, NICKEL (II) ION, ... 著者 Krojer, T, Vollmar, M, Crawley, L, Szykowska, A, Gileadi, C, Johansson, C, England, K, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) 登録日 2015-12-04 公開日 2015-12-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
5FB1	Crystal Structure of a PHD finger bound to histone H3 K9me3 peptide 分子名称: MALONATE ION, Nuclear autoantigen Sp-100, Peptide from Histone H3, ... 著者 Li, H, Zhang, X. 登録日 2015-12-13 公開日 2016-05-04 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C J.Biol.Chem., 291, 2016
5FB0	Crystal Structure of a PHD finger bound to histone H3 T3ph peptide 分子名称: Nuclear autoantigen Sp-100, Peptide from Histone H3, ZINC ION 著者 Li, H, Zhang, X. 登録日 2015-12-13 公開日 2016-05-04 最終更新日 2016-06-22 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C J.Biol.Chem., 291, 2016
2RVN	Solution structure of the chromodomain of HP1a with the phosphorylated N-terminal tail complexed with H3K9me3 peptide 分子名称: 18-mer peptide of Histone H3, Chromobox protein homolog 5 著者 Kawaguchi, A, Nishimura, Y. 登録日 2015-12-18 公開日 2016-03-16 実験手法 SOLUTION NMR 主引用文献 Extended string-like binding of the phosphorylated HP1 alpha N-terminal tail to the lysine 9-methylated histone H3 tail Sci Rep, 6, 2016
5IAY	NMR structure of UHRF1 Tandem Tudor Domains in a complex with Spacer peptide 分子名称: E3 ubiquitin-protein ligase UHRF1, Spacer 著者 Fang, J, Cheng, J, Wang, J, Zhang, Q, Liu, M, Gong, R, Wang, P, Zhang, X, Feng, Y, Lan, W, Gong, Z, Tang, C, Wong, J, Yang, H, Cao, C, Xu, Y. 登録日 2016-02-22 公開日 2016-04-20 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition Nat Commun, 7, 2016

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