PDB: 19228 件ウェブページステータス検索Chemie searchBIRD

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4S30	ERK2 intrinsically active mutant (I84A) 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2015-01-26 公開日 2016-01-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Multiple mechanisms render Erk proteins MEK-independent To be Published
6RW4	Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF3 分子名称: 12S mitochondrial rRNA, 28S ribosomal protein S10, mitochondrial, ... 著者 Itoh, Y, Khawaja, A, Rorbach, J, Amunts, A. 登録日 2019-06-03 公開日 2020-06-03 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Distinct pre-initiation steps in human mitochondrial translation. Nat Commun, 11, 2020
4GIG	crystal structure of T69A mutant of trapped Dnae intein precursor 分子名称: DNA polymerase III subunit alpha, SULFATE ION 著者 Van Roey, P. 登録日 2012-08-08 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A conserved threonine spring-loads precursor for intein splicing. Protein Sci., 22, 2013
4X3R	Avi-GCPII structure in complex with FITC-conjugated GCPII-specific inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Tykvart, J, Konvalinka, J. 登録日 2014-12-01 公開日 2015-10-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II. J.Med.Chem., 58, 2015
4X5P	Crystal structure of FimH in complex with a benzoyl-amidophenyl alpha-D-mannopyranoside 分子名称: 4-{[3-chloro-4-(alpha-D-mannopyranosyloxy)phenyl]carbamoyl}benzoic acid, Protein FimH 著者 Preston, R.C, Jakob, R.P, Fiege, B, Zihlmann, P, Rabbani, S, Schwardt, O, Jiang, X, Ernst, B, Maier, T. 登録日 2014-12-05 公開日 2015-05-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (0.997 Å) 主引用文献 The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. Chembiochem, 16, 2015
6RMN	DNA mismatch repair proteins MLH1 and MLH3 分子名称: DNA mismatch repair protein MLH1, DNA mismatch repair protein MLH3, ZINC ION 著者 Dai, J, Chervy, P, Legrand, P, Ropars, V, Charbonnier, J.B. 登録日 2019-05-07 公開日 2021-05-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formation. Proc.Natl.Acad.Sci.USA, 118, 2021
4X50	Crystal structure of FimH in complex with biphenyl alpha-D-mannopyranoside 分子名称: Protein FimH, biphenyl-4-yl alpha-D-mannopyranoside 著者 Preston, R.C, Jakob, R.P, Fiege, B, Zihlmann, P, Rabbani, S, Schwardt, O, Jiang, X, Ernst, B, Maier, T. 登録日 2014-12-04 公開日 2015-05-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. Chembiochem, 16, 2015
4RLP	Human p70s6k1 with ruthenium-based inhibitor FL772 分子名称: CHLORIDE ION, [(amino-kappaN)methanethiolato](3-fluoro-9-methoxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(N-methyl-1,4,7-trithiecan-9-amine-kappa~3~S~1~,S~4~,S~7~)ruthenium, p70S6K1 著者 Domsic, J.F, Barber-Rotenberg, J, Salami, J, Qin, J, Marmorstein, R. 登録日 2014-10-17 公開日 2015-01-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Development of Organometallic S6K1 Inhibitors. J.Med.Chem., 58, 2015
4RM9	Crystal structure of human ezrin in space group C2221 分子名称: Ezrin 著者 Phang, J.M, Harrop, S.J, Davies, R, Duff, A.P, Wilk, K.E, Curmi, P.M.G. 登録日 2014-10-21 公開日 2015-12-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin. Biochem. J., 473, 2016
6S9W	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 16a 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{H}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2019-07-15 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
4RV1	Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium (NESG) Target OR497. 分子名称: ACETATE ION, Engineered Protein OR497 著者 Vorobiev, S, Parmeggiani, F, Seetharaman, J, Xiao, R, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2014-11-24 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.573 Å) 主引用文献 Crystal Structure of Engineered Protein OR497. To be Published
4X5Q	Crystal structure of FimH in complex with 5-nitro-indolinylphenyl alpha-D-mannopyranoside 分子名称: 4-(5-nitro-1H-indol-1-yl)phenyl alpha-D-mannopyranoside, Protein FimH 著者 Preston, R.C, Jakob, R.P, Fiege, B, Zihlmann, P, Rabbani, S, Schwardt, O, Jiang, X, Ernst, B, Maier, T. 登録日 2014-12-05 公開日 2015-05-20 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 The Tyrosine Gate of the Bacterial Lectin FimH: A Conformational Analysis by NMR Spectroscopy and X-ray Crystallography. Chembiochem, 16, 2015
6S9X	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 15c 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-[(4-hydroxyphenyl)methyl]-6-oxidanylidene-2-phenyl-1~{H}-pyrazin-3-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2019-07-15 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019
4G69	Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex 分子名称: Adenomatous polyposis coli protein, Disks large homolog 1 著者 Slep, K.C. 登録日 2012-07-18 公開日 2012-12-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the Human Discs Large 1 PDZ2- Adenomatous Polyposis Coli Cytoskeletal Polarity Complex: Insight into Peptide Engagement and PDZ Clustering. Plos One, 7, 2012
4RKW	Crystal structure of DJ-1 分子名称: Protein DJ-1 著者 Liddington, R.C. 登録日 2014-10-14 公開日 2015-08-26 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models. J.Neurosci., 34, 2014
4RLO	Human p70s6k1 with ruthenium-based inhibitor EM5 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Domsic, J.F, Barber-Rotenberg, J, Salami, J, Qin, J, Marmorstein, R. 登録日 2014-10-17 公開日 2015-01-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.527 Å) 主引用文献 Development of Organometallic S6K1 Inhibitors. J.Med.Chem., 58, 2015
4WUD	N-terminal 43 kDa fragment of the E. coli DNA gyrase B subunit grown from no salt condition 分子名称: CHLORIDE ION, DNA gyrase subunit B, MAGNESIUM ION, ... 著者 Hearnshaw, S.J, Chung, T.T, Stevenson, C.E.M, Maxwell, A, Lawson, D.M. 登録日 2014-10-31 公開日 2015-04-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The role of monovalent cations in the ATPase reaction of DNA gyrase Acta Crystallogr.,Sect.D, 71, 2015
6SEH	Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease 分子名称: Structure-specific endonuclease subunit SLX1, Structure-specific endonuclease subunit SLX4, ZINC ION 著者 Gaur, V, Zajko, W, Nirwal, S, Szlachcic, A, Gapinska, M, Nowotny, M. 登録日 2019-07-30 公開日 2019-09-25 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Recognition and processing of branched DNA substrates by Slx1-Slx4 nuclease. Nucleic Acids Res., 47, 2019
4RU2	Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution 分子名称: RNA-binding protein 39 (RBM39), Splicing factor U2AF 65 kDa subunit 著者 Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) 登録日 2014-11-17 公開日 2015-02-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution To be published
6Q7K	ERK2 mini-fragment binding 分子名称: 1H-imidazol-2-amine, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. 登録日 2018-12-13 公開日 2019-03-27 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
4WX4	Crystal structure of adenovirus 8 protease in complex with a nitrile inhibitor 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCINE, N-[(2-cyanopyrimidin-4-yl)methyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide, ... 著者 Grosche, P, Sirockin, F, Mac Sweeney, A, Ramage, P, Erbel, P, Melkko, S, Bernardi, A, Hughes, N, Ellis, D, Combrink, K, Jarousse, N, Altmann, E. 登録日 2014-11-13 公開日 2015-01-14 最終更新日 2015-01-28 実験手法 X-RAY DIFFRACTION (1.03 Å) 主引用文献 Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg.Med.Chem.Lett., 25, 2015
6SKL	Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1 分子名称: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA fork, ... 著者 Yeeles, J, Baretic, D, Jenkyn-Bedford, M. 登録日 2019-08-16 公開日 2020-05-06 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. Mol.Cell, 78, 2020
4X22	Crystal structure of Leptospira Interrogans Triosephosphate Isomerase (LiTIM) 分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Triosephosphate isomerase 著者 Pareek, V, Balaram, P, Murthy, M.R.N. 登録日 2014-11-25 公開日 2016-02-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.084 Å) 主引用文献 Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme Chembiochem, 17, 2016
4WXJ	Drosophila muscle GluRIIB complex with glutamate 分子名称: GLUTAMIC ACID, Glutamate receptor IIB,Glutamate receptor IIB 著者 Dharkar, P, Mayer, M.L. 登録日 2014-11-13 公開日 2015-04-29 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. Proc.Natl.Acad.Sci.USA, 112, 2015
6PTJ	Structure of Ctf4 trimer in complex with one CMG helicase 分子名称: Cell division control protein 45, DNA polymerase alpha-binding protein, DNA replication complex GINS protein PSF1, ... 著者 Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H. 登録日 2019-07-15 公開日 2019-11-20 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife, 8, 2019

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