PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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6E3L	Interferon gamma signalling complex with IFNGR1 and IFNGR2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ... 著者 Jude, K.M, Mendoza, J.L, Garcia, K.C. 登録日 2018-07-14 公開日 2019-02-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
5IEY	Crystal structure of a CDK inhibitor bound to CDK2 分子名称: 4-[(4-{[(2R,3R)-3-hydroxybutan-2-yl]amino}pyrimidin-2-yl)amino]benzene-1-sulfonamide, Cyclin-dependent kinase 2 著者 Ayaz, P, Andres, D, Kwiatkowski, D.A, Kolbe, C, Lienau, P, Siemeister, G, Luecking, U, Stegmann, C.M. 登録日 2016-02-25 公開日 2016-04-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9. Acs Chem.Biol., 11, 2016
5GW9	Crystal structure of C163, a backbone circularized G-CSF 分子名称: Granulocyte colony-stimulating factor 著者 Miyafusa, T, Honda, S. 登録日 2016-09-09 公開日 2017-09-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into the backbone-circularized granulocyte colony-stimulating factor containing a short connector. Biochem. Biophys. Res. Commun., 500, 2018
5GPD	Crystal structure of the binding domain of SREBP from fission yeast 分子名称: Sterol regulatory element-binding protein 1 著者 Gong, X, Qian, H.W, Wu, J.P, Yan, N. 登録日 2016-08-01 公開日 2016-11-23 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization Cell Res., 26, 2016
5X3F	Crystal structure of the YgjG-Protein A-Zpa963-PKA catalytic domain 分子名称: Putrescine aminotransferase,Immunoglobulin G-binding protein A, Zpa963,cAMP-dependent protein kinase catalytic subunit alpha 著者 Youn, S.J, Kwon, N.Y, Lee, J.H, Kim, J.H, Lee, H, Lee, J.O. 登録日 2017-02-05 公開日 2017-06-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.38 Å) 主引用文献 Construction of novel repeat proteins with rigid and predictable structures using a shared helix method. Sci Rep, 7, 2017
5GRS	Complex structure of the fission yeast SREBP-SCAP binding domains 分子名称: Sterol regulatory element-binding protein 1, Sterol regulatory element-binding protein cleavage-activating protein 著者 Gong, X, Qian, H.W, Wu, J.P, Yan, N. 登録日 2016-08-12 公開日 2016-12-14 最終更新日 2019-10-23 実験手法 ELECTRON MICROSCOPY (5.4 Å) 主引用文献 Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization Cell Res., 26, 2016
5ILU	Autoinhibited ETV4 分子名称: ETS translocation variant 4 著者 Whitby, F.G, Currie, S.L. 登録日 2016-03-04 公開日 2017-02-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.101 Å) 主引用文献 Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res., 45, 2017
6EYC	Re-refinement of the MCM2-7 double hexamer using ISOLDE 分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... 著者 Croll, T.I. 登録日 2017-11-11 公開日 2018-06-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Acta Crystallogr D Struct Biol, 74, 2018
3L2O	Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase 分子名称: F-box only protein 4, S-phase kinase-associated protein 1 著者 Li, Y, Hao, B. 登録日 2009-12-15 公開日 2010-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. J.Biol.Chem., 285, 2010
1XFV	Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP 分子名称: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ... 著者 Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. 登録日 2004-09-15 公開日 2005-05-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
1XFW	Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP) 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, Calmodulin 2, ... 著者 Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J. 登録日 2004-09-15 公開日 2005-05-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J., 24, 2005
2ZOQ	Structural dissection of human mitogen-activated kinase ERK1 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, Mitogen-activated protein kinase 3, SODIUM ION, ... 著者 Kinoshita, T, Tada, T, Nakae, S, Yoshida, I. 登録日 2008-06-01 公開日 2009-04-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Crystal structure of human mono-phosphorylated ERK1 at Tyr204 Biochem.Biophys.Res.Commun., 377, 2008
6S9S	Dimerization domain of Xenopus laevis LDB1 in complex with darpin 10 分子名称: Darpin 10, LIM domain-binding protein 1 著者 Renko, M, Schaefer, J.V, Pluckthun, A, Bienz, M. 登録日 2019-07-15 公開日 2019-10-09 最終更新日 2019-10-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019
3X2V	Michaelis-like complex of cAMP-dependent Protein Kinase Catalytic Subunit 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, MAGNESIUM ION, ... 著者 Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. 登録日 2015-01-02 公開日 2015-12-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
6SJA	Structure of HPV16 E6 oncoprotein in complex with IRF3 LxxLL motif 分子名称: Maltose/maltodextrin-binding periplasmic protein,Interferon regulatory factor 3, Protein E6, ZINC ION, ... 著者 Suarez, I.P, Cousido-Siah, A, Bonhoure, A, Mitschler, A, Podjarny, A, Trave, G. 登録日 2019-08-13 公開日 2019-09-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Deciphering de molecular and structural interaction between IRF3 and HPV16 E6 To be published
6SVL	human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab 分子名称: Fab_heavy_chain, Fab_light_chain, GLYCEROL, ... 著者 Ebenhoch, R, Nar, H. 登録日 2019-09-18 公開日 2019-11-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair. Nat Commun, 10, 2019
6SXB	XPF-ERCC1 Cryo-EM Structure, DNA-Bound form 分子名称: DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3'), DNA excision repair protein ERCC-1, ... 著者 Jones, M.L, Briggs, D.C, McDonald, N.Q. 登録日 2019-09-25 公開日 2020-03-11 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (7.9 Å) 主引用文献 Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
7V7C	CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
3X2U	Michaelis-like initial complex of cAMP-dependent Protein Kinase Catalytic Subunit. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Substrate Peptide, ... 著者 Das, A, Langan, P, Gerlits, O, Kovalevsky, A.Y, Heller, W.T. 登録日 2015-01-02 公開日 2015-12-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Protein Kinase A Catalytic Subunit Primed for Action: Time-Lapse Crystallography of Michaelis Complex Formation. Structure, 23, 2015
6SVK	human Myeloid-derived growth factor (MYDGF) 分子名称: MALONATE ION, Myeloid-derived growth factor 著者 Ebenhoch, R, Nar, H. 登録日 2019-09-18 公開日 2019-11-27 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (1.604 Å) 主引用文献 Crystal structure and receptor-interacting residues of MYDGF - a protein mediating ischemic tissue repair. Nat Commun, 10, 2019
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation 分子名称: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 著者 Wang, D, Xu, J, Liu, Q, Xiang, Y. 登録日 2021-08-21 公開日 2022-08-31 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
6SLX	Fragment AZ-010 binding at the TAZpS89/14-3-3 sigma interface 分子名称: 14-3-3 protein sigma, TAZpS89, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]propanamide 著者 Ottmann, C, Wolter, M, Guillory, X, Genet, S, Somsen, B, Leysen, S, Castaldi, P. 登録日 2019-08-20 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.800045 Å) 主引用文献 Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
7VD4	Crystal structure of BPTF-BRD with ligand TP248 bound 分子名称: 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF 著者 Lu, T, Lu, H.B. 登録日 2021-09-06 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.85659146 Å) 主引用文献 Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123, 2022
6SQ4	Crystal structure of mouse PRMT6 in complex with inhibitor U2 分子名称: 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine, IODIDE ION, Protein arginine N-methyltransferase 6 著者 Bonnefond, L, Cavarelli, J. 登録日 2019-09-03 公開日 2020-09-30 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of mouse PRMT6 in complex with inhibitors To be published
6SQ3	Crystal structure of mouse PRMT6 in complex with inhibitor U1 分子名称: Protein arginine N-methyltransferase 6, [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium 著者 Bonnefond, L, Cavarelli, J. 登録日 2019-09-03 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal structure of mouse PRMT6 in complex with inhibitors To Be Published

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