PDB: 1980 件ウェブページステータス検索Chemie searchBIRD

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4R71	Structure of the Qbeta holoenzyme complex in the P1211 crystal form 分子名称: 30S ribosomal protein S1, Elongation factor Ts, Elongation factor Tu, ... 著者 Gytz, H, Seweryn, P, Kutlubaeva, Z, Chetverin, A.B, Brodersen, D.E, Knudsen, C.R. 登録日 2014-08-26 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structural basis for RNA-genome recognition during bacteriophage Q beta replication. Nucleic Acids Res., 43, 2015
6U1X	Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor (3.0 A resolution) 分子名称: Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION 著者 Jenni, S, Bloyet, L.M, Dias-Avalos, R, Liang, B, Wheelman, S.P.J, Grigorieff, N, Harrison, S.C. 登録日 2019-08-17 公開日 2020-01-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep, 30, 2020
7X6V	lymphocytic choriomeningitis virus polymerase- Matrix Z Protein Complex (LCMV L-Z Complex) 分子名称: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... 著者 Liu, L, Lou, Z. 登録日 2022-03-08 公開日 2023-09-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
7ELC	Structure of monomeric complex of MACV L bound to Z and 3'-vRNA 分子名称: 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... 著者 Xu, X, Peng, R, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
8POH	Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R) 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-04 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
3CDE	Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2008-02-26 公開日 2009-03-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg.Med.Chem.Lett., 18, 2008
3TYQ	SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase 分子名称: 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Lesburg, C.A, Chen, K.X. 登録日 2011-09-26 公開日 2012-02-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors. J.Med.Chem., 55, 2012
7ELB	Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) 分子名称: MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... 著者 Peng, R, Xu, X, Peng, Q, Shi, Y. 登録日 2021-04-09 公開日 2021-05-05 最終更新日 2021-07-14 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
8P1N	Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA 分子名称: RNA (5'-R(P*AP*GP*UP*AP*G)-3'), RNA-directed RNA polymerase L 著者 Keown, J.R, Carrique, L, Grimes, J.M. 登録日 2023-05-12 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 Structure of hantaan orthohantavirus (HTNV) polymerase bound to 5'vRNA To Be Published
8KDB	Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form 分子名称: MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... 著者 Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. 登録日 2023-08-09 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
8KDC	Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form 分子名称: MAGNESIUM ION, Phosphoprotein, RNA-directed RNA polymerase L, ... 著者 Xie, J, Wang, L, Zhai, G, Wu, D, Lin, Z, Wang, M, Yan, X, Gao, L, Huang, X, Fearns, R, Chen, S. 登録日 2023-08-09 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for dimerization of a paramyxovirus polymerase complex. Nat Commun, 15, 2024
3LKH	Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides 分子名称: 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide, RNA-directed RNA polymerase 著者 Lesburg, C.A. 登録日 2010-01-27 公開日 2010-03-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. Bioorg.Med.Chem.Lett., 20, 2010
8X01	Structure of the Mumps Virus L Protein (state2) Bound by Phosphoprotein Tetramer 分子名称: Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION 著者 Li, T.H, Shen, Q.T. 登録日 2023-11-02 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structures of the mumps virus polymerase complex via cryo-electron microscopy. Nat Commun, 15, 2024
7Y38	Molecular architecture of the chikungunya virus replication complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Protease nsP2, ... 著者 Tan, Y.B, Luo, D. 登録日 2022-06-10 公開日 2022-12-14 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Molecular architecture of the Chikungunya virus replication complex. Sci Adv, 8, 2022
8YXM	Structure of N-terminal domain of L protein bound with Phosphoprotein from Mumps Virus 分子名称: Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION 著者 Li, T.H, Shen, Q.T. 登録日 2024-04-02 公開日 2024-06-05 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 Structures of the mumps virus polymerase complex via cryo-electron microscopy. Nat Commun, 15, 2024
8QGT	5'vRNA-bound Hantaan virus polymerase in monomeric intermediate state 分子名称: RNA (5'-R(P*UP*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*A)-3'), RNA-directed RNA polymerase L 著者 Durieux Trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-09-05 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers. Nat Commun, 15, 2024
8QH3	5'vRNA-bound Hantaan virus polymerase in monomeric active state 分子名称: MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*A)-3'), RNA-directed RNA polymerase L 著者 Durieux Trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-09-06 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers. Nat Commun, 15, 2024
3CWJ	Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-DIRECTED RNA POLYMERASE 著者 Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. 登録日 2008-04-21 公開日 2009-04-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase Bioorg.Med.Chem.Lett., 18, 2008
6KUU	Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) 分子名称: 3'-vRNA, 5'-vRNA, Polymerase 3, ... 著者 Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. 登録日 2019-09-02 公開日 2019-12-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3) To Be Published
8PM0	Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-06-27 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
4EO8	HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres 分子名称: 5-(3,3-dimethylbut-1-yn-1-yl)-3-{2,2-dimethyl-1-[(trans-4-methylcyclohexyl)carbonyl]hydrazinyl}thiophene-2-carboxylic acid, RNA-directed RNA polymerase 著者 Appleby, T.C, Canales, E, Watkins, W.J. 登録日 2012-04-13 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
4MZ4	Discovery of an Irreversible HCV NS5B Polymerase Inhibitor 分子名称: 1-[(2-chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase 著者 Zeng, Q, Anilkumar, G.N, Rosenblum, S.B, Huang, H.-C, Lesburg, C.A, Jiang, Y, Selyutin, O, Chan, T.-Y, Bennett, F, Chen, K.X, Venkatraman, S, Sannigrahi, M, Velazquez, F, Duca, J.S, Gavalas, S, Huang, Y, Pu, H, Wang, L, Pinto, P, Vibulbhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Li, C, Hesk, D, Gesell, J, Sorota, S, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. 登録日 2013-09-29 公開日 2013-12-11 最終更新日 2013-12-18 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Discovery of an irreversible HCV NS5B polymerase inhibitor. Bioorg.Med.Chem.Lett., 23, 2013
4EO6	HCV NS5B polymerase inhibitors: Tri-substituted acylhydrazines as tertiary amide bioisosteres 分子名称: 5-(3,3-dimethylbut-1-yn-1-yl)-3-{[(trans-4-methylcyclohexyl)carbonyl](propan-2-yl)amino}thiophene-2-carboxylic acid, RNA-directed RNA polymerase 著者 Appleby, T.C, Canales, E, Watkins, W.J. 登録日 2012-04-13 公開日 2012-06-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.791 Å) 主引用文献 Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
8GZR	Cryo-EM structure of the the NS5-NS3 RNA-elongation complex 分子名称: CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... 著者 Osawa, T, Ehara, H, Sekine, S. 登録日 2022-09-27 公開日 2023-08-02 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
6KUJ	Structure of influenza D virus polymerase bound to cRNA promoter in class 1 分子名称: 3'-cRNA promoter, 5'-cRNA promoter, Polymerase 3, ... 著者 Peng, Q, Peng, R, Qi, J, Gao, G.F, Shi, Y. 登録日 2019-09-02 公開日 2019-10-02 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of influenza D virus polymerase bound to cRNA promoter in Mode A conformation NAT NANOTECHNOL, 2019

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