8Q4P
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8Q2R
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![BU of 8q2r by Molmil](/molmil-images/mine/8q2r) | Crystal structure of YTHDC1 in complex with Compound 3 (ZA_431) | 分子名称: | 5-chloranyl-~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Zalesak, F, Li, Y, Caflisch, A. | 登録日 | 2023-08-03 | 公開日 | 2023-12-06 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024
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8Q2Y
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8Q3G
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8Q4W
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![BU of 8q4w by Molmil](/molmil-images/mine/8q4w) | Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a) | 分子名称: | 5-chloranyl-3-[(3-chlorophenyl)methyl]-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Zalesak, F, Caflisch, A. | 登録日 | 2023-08-07 | 公開日 | 2023-12-06 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024
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8Q2X
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8Q2S
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8Q3A
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8Q35
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8Q4N
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8Q2U
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8Q2V
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8Q37
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8Q39
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![BU of 8q39 by Molmil](/molmil-images/mine/8q39) | Crystal structure of YTHDC1 in complex with Compound 21 (ZA_515) | 分子名称: | 2-chloranyl-N-methyl-9-[[3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl]purin-6-amine, SULFATE ION, YTH domain-containing protein 1 | 著者 | Bedi, R.K, Zalesak, F, Caflisch, A. | 登録日 | 2023-08-03 | 公開日 | 2023-12-06 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67, 2024
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8Q4M
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8Q4T
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7WCV
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![BU of 7wcv by Molmil](/molmil-images/mine/7wcv) | Co-crystal structure of FTO bound to 6e | 分子名称: | 2-OXOGLUTARIC ACID, 2-[[2,6-bis(chloranyl)-4-pyridin-4-yl-phenyl]amino]benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | 著者 | Yang, C.-G, Gan, J.H. | 登録日 | 2021-12-20 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors. J.Med.Chem., 65, 2022
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6RMF
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![BU of 6rmf by Molmil](/molmil-images/mine/6rmf) | Crystal structure of NDM-1 with VNRX-5133 | 分子名称: | (10aR)-2-(((1r,4R)-4-((2-aminoethyl)amino)cyclohexyl)methyl)-6-carboxy-4-hydroxy-4,10a-dihydro-10H-benzo[5,6][1,2]oxaborinino[2,3-b][1,4,2]oxazaborol-4-uide, (4~{R})-4-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-3,3-bis(oxidanyl)-2-oxa-3-boranuidabicyclo[4.4.0]deca-1(10),6,8-triene-10-carboxylic acid, Metallo-beta-lactamase type 2, ... | 著者 | Hinchliffe, P, Spencer, J, Brem, J, Schofield, C.J. | 登録日 | 2019-05-06 | 公開日 | 2019-09-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-beta-Lactamases. J.Med.Chem., 62, 2019
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8AAK
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![BU of 8aak by Molmil](/molmil-images/mine/8aak) | Crystal structure of the PDZ tandem of syntenin in complex with compound 29 | 分子名称: | (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1 | 著者 | Feracci, M, Barral, K. | 登録日 | 2022-07-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.554 Å) | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAP
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![BU of 8aap by Molmil](/molmil-images/mine/8aap) | Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi | 分子名称: | (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1 | 著者 | Feracci, M, Barral, K. | 登録日 | 2022-07-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.174 Å) | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAO
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![BU of 8aao by Molmil](/molmil-images/mine/8aao) | Crystal structure of the PDZ tandem of syntenin in complex with compound 95 | 分子名称: | (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1 | 著者 | Feracci, M, Barral, K. | 登録日 | 2022-07-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.469 Å) | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAI
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6XUG
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6XUQ
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8BQ4
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