8BQ4

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an inhibitor

Summary for 8BQ4

• Entry DOI: 10.2210/pdb8bq4/pdb
• Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, 6-methyl-~{N}-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: lipid kinase, atp-competitive inhibitor, phosphatidylinositol 5-phosphate, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 84674.64

Authors

Ogg, D.J.,Howard, T.D. (deposition date: 2022-11-18, release date: 2022-12-28, Last modification date: 2024-02-07)

• Primary citation: Rooney, T.P.C.,Aldred, G.G.,Boffey, H.K.,Willems, H.M.G.,Edwards, S.,Chawner, S.J.,Scott, D.E.,Green, C.,Winpenny, D.,Skidmore, J.,Clarke, J.H.,Andrews, S.P.; The Identification of Potent, Selective, and Brain Penetrant PI5P4K gamma Inhibitors as In Vivo-Ready Tool Molecules.; J.Med.Chem., 66:804-821, 2023; PubMed: 36516442; DOI: 10.1021/acs.jmedchem.2c01693

Experimental method

X-RAY DIFFRACTION (2.42 Å)