8BQ4

Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	polymer	363	42017.9	2	UniProt (Q8TBX8) Pfam (PF01504) In PDB	Homo sapiens (human)	Phosphatidylinositol 5-phosphate 4-kinase type II gamma,PI(5)P 4-kinase type II gamma,PIP4KII-gamma
2	A, B	6-methyl-~{N}-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine	non-polymer		319.4	2	Chemie (QZR)
3		water	water		18.0	38	Chemie (HOH)

Sequence modifications

A, B: 32 - 341 (UniProt: Q8TBX8)

PDB	External Database	Details
Met 17	-	initiating methionine
Gly 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
Glu 25	-	expression tag
Asn 26	-	expression tag
Leu 27	-	expression tag
Tyr 28	-	expression tag
Phe 29	-	expression tag
Gln 30	-	expression tag
Gly 31	-	expression tag

A, B: 342 - 421 (UniProt: Q8TBX8)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84035.8
Non-Polymers*	Number of molecules	2
	Total formula weight	638.8
All*	Total formula weight	84674.6

*Water molecules are not included.