8Q39
Crystal structure of YTHDC1 in complex with Compound 21 (ZA_515)
Summary for 8Q39
| Entry DOI | 10.2210/pdb8q39/pdb |
| Descriptor | YTH domain-containing protein 1, 2-chloranyl-N-methyl-9-[[3-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl]purin-6-amine, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | ythdc1, inhibitor, complex, reader, rna binding protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 38907.55 |
| Authors | Bedi, R.K.,Zalesak, F.,Caflisch, A. (deposition date: 2023-08-03, release date: 2023-12-06, Last modification date: 2024-06-19) |
| Primary citation | Zalesak, F.,Nai, F.,Herok, M.,Bochenkova, E.,Bedi, R.K.,Li, Y.,Errani, F.,Caflisch, A. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67:9516-9535, 2024 Cited by PubMed: 38787793DOI: 10.1021/acs.jmedchem.4c00599 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.42 Å) |
Structure validation
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