8Q3G

Crystal structure of YTHDC1 in complex with Compound 23 (ZA_385)

Summary for 8Q3G

Entry DOI	10.2210/pdb8q3g/pdb
Descriptor	YTH domain-containing protein 1, 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]-~{N}-methyl-benzamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	ythdc1, inhibitor, complex, reader, rna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	38885.57
Authors	Bedi, R.K.,Zalesak, F.,Caflisch, A. (deposition date: 2023-08-04, release date: 2023-12-06, Last modification date: 2024-06-19)
Primary citation	Zalesak, F.,Nai, F.,Herok, M.,Bochenkova, E.,Bedi, R.K.,Li, Y.,Errani, F.,Caflisch, A. Structure-Based Design of a Potent and Selective YTHDC1 Ligand. J.Med.Chem., 67:9516-9535, 2024 Cited by PubMed: 38787793 DOI: 10.1021/acs.jmedchem.4c00599 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation