5JYX
 
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5K0P
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3QO9
 | | Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI) | | 分子名称: | 1-[(5R,6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4(1H,3H)-dione, Reverse transcriptase/ ribonuclease H, p51 RT | | 著者 | Das, K, Arnold, E. | | 登録日 | 2011-02-09 | | 公開日 | 2011-05-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket.
J.Med.Chem., 54, 2011
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6SEG
 | | Class1: CENP-A nucleosome in complex with CENP-C central region | | 分子名称: | DNA (145-MER), Histone H2A type 2-A, Histone H2B type 1-C/E/F/G/I, ... | | 著者 | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | | 登録日 | 2019-07-30 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.
Embo Rep., 20, 2019
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6SE0
 | | Class 1 : CENP-A nucleosome | | 分子名称: | DNA (145-MER), Histone H2A type 2-A, Histone H2B type 1-C/E/F/G/I, ... | | 著者 | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | | 登録日 | 2019-07-29 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.
Embo Rep., 20, 2019
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6SE6
 | | Class2 : CENP-A nucleosome in complex with CENP-C central region | | 分子名称: | Centromere protein C, DNA (145-MER), Histone H2A type 2-A, ... | | 著者 | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | | 登録日 | 2019-07-29 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.
Embo Rep., 20, 2019
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6SEE
 | | Class2A : CENP-A nucleosome in complex with CENP-C central region | | 分子名称: | Centromere protein C, DNA (145-MER), Histone H2A type 2-A, ... | | 著者 | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | | 登録日 | 2019-07-29 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.
Embo Rep., 20, 2019
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3G5I
 | | Crystal Structure of the E.coli RihA pyrimidine nucleosidase bound to a iminoribitol-based inhibitor | | 分子名称: | (2S,3S,4R,5R)-2-(3,4-diaminophenyl)-5-(hydroxymethyl)pyrrolidine-3,4-diol, BETA-MERCAPTOETHANOL, CALCIUM ION, ... | | 著者 | Garau, G, Muzzolini, L, Tornaghi, P, Degano, M. | | 登録日 | 2009-02-05 | | 公開日 | 2010-02-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor.
Bmc Struct.Biol., 10, 2010
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6SEF
 | | Class2C : CENP-A nucleosome in complex with CENP-C central region | | 分子名称: | Centromere protein C, DNA (145-MER), Histone H2A type 2-A, ... | | 著者 | Ali-Ahmad, A, Bilokapic, S, Schafer, I.B, Halic, M, Sekulic, N. | | 登録日 | 2019-07-29 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.
Embo Rep., 20, 2019
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6INQ
 | | RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome, with foreign DNA (+1 position) | | 分子名称: | DNA (198-MER), DNA (31-MER), DNA-directed RNA polymerase subunit, ... | | 著者 | Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. | | 登録日 | 2018-10-26 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | | 主引用文献 | Structural basis of the nucleosome transition during RNA polymerase II passage.
Science, 362, 2018
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6PWV
 | | Cryo-EM structure of MLL1 core complex bound to the nucleosome | | 分子名称: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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1KX5
 | | X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution | | 分子名称: | CHLORIDE ION, DNA (5'(ATCAATATCCACCTGCAGATACTACCAAAAGTGTATTTGGAAACTGCTCCATCAAAAGGCATGTTCAGCTGGAATCCAGCTGAACATGCCTTTTGATGGAGCAGTTTCCAAATACACTTTTGGTAGTATCTGCAGGTGGATATTGAT)3'), DNA (5'(ATCAATATCCACCTGCAGATACTACCAAAAGTGTATTTGGAAACTGCTCCATCAAAAGGCATGTTCAGCTGGATTCCAGCTGAACATGCCTTTTGATGGAGCAGTTTCCAAATACACTTTTGGTAGTATCTGCAGGTGGATATTGAT)3'), ... | | 著者 | Davey, C.A, Sargent, D.F, Luger, K, Maeder, A.W, Richmond, T.J. | | 登録日 | 2002-01-31 | | 公開日 | 2002-12-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9 A Resolution
J.Mol.Biol., 319, 2002
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1KX3
 | | X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution | | 分子名称: | DNA (5'(ATCAATATCCACCTGCAGATTCTACCAAAAGTGTATTTGGAAACTGCTCCATCAAAAGGCATGTTCAGCTGAATTCAGCTGAACATGCCTTTTGATGGAGCAGTTTCCAAATACACTTTTGGTAGAATCTGCAGGTGGATATTGAT)3'), MANGANESE (II) ION, histone H2A.1, ... | | 著者 | Davey, C.A, Sargent, D.F, Luger, K, Maeder, A.W, Richmond, T.J. | | 登録日 | 2002-01-31 | | 公開日 | 2002-12-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9 A Resolution
J.Mol.Biol., 319, 2002
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1KX4
 | | X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution | | 分子名称: | CHLORIDE ION, DNA (5'(ATCTCCAAATATCCCTTGCGGATCGTAGAAAAAGTGTGTCAAACTGCGCTATCAAAGGGAAACTTCAACTGAATTCAGTTGAAGTTTCCCTTTGATAGCGCAGTTTGACACACTTTTTCTACGATCCGCAAGGGATATTTGGAGAT)3'), MANGANESE (II) ION, ... | | 著者 | Davey, C.A, Sargent, D.F, Luger, K, Maeder, A.W, Richmond, T.J. | | 登録日 | 2002-01-31 | | 公開日 | 2002-12-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9 A Resolution
J.Mol.Biol., 319, 2002
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8OFF
 | | Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1) | | 分子名称: | BRCA1 associated RING domain 1, DNA (142-MER), Histone H2A type 1, ... | | 著者 | Foglizzo, M, Burdett, H, Wilson, M.D, Zeqiraj, E. | | 登録日 | 2023-03-15 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes.
Nucleic Acids Res., 51, 2023
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6K1P
 | | The complex of ISWI-nucleosome in the ADP.BeF-bound state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | | 著者 | Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. | | 登録日 | 2019-05-10 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-09-25 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
Nat.Struct.Mol.Biol., 26, 2019
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6JYL
 | | The crosslinked complex of ISWI-nucleosome in the ADP.BeF-bound state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | | 著者 | Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. | | 登録日 | 2019-04-26 | | 公開日 | 2019-05-29 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
Nat.Struct.Mol.Biol., 26, 2019
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5LU0
 | | Crystal structure of H. pylori referent strain in complex with PO4 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, ... | | 著者 | Stefanic, Z. | | 登録日 | 2016-09-07 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features.
FEBS J., 285, 2018
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4LD9
 | | Crystal structure of the N-terminally acetylated BAH domain of Sir3 bound to the nucleosome core particle | | 分子名称: | Histone H2A, Histone H2B 1.1, Histone H3.2, ... | | 著者 | Arnaudo, N, Fernandez, I.S, McLaughlin, S.H, Peak-Chew, S.Y, Rhodes, D, Martino, F. | | 登録日 | 2013-06-24 | | 公開日 | 2013-08-14 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.306 Å) | | 主引用文献 | The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle.
Nat.Struct.Mol.Biol., 20, 2013
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6EXN
 | | Post-catalytic P complex spliceosome with 3' splice site docked | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ... | | 著者 | Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K. | | 登録日 | 2017-11-08 | | 公開日 | 2018-01-17 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Science, 358, 2017
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1YOE
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5B24
 | | The crystal structure of the nucleosome containing cyclobutane pyrimidine dimer | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Horikoshi, N, Tachiwana, H, Kagawa, W, Osakabe, A, Kurumizaka, H. | | 登録日 | 2015-12-31 | | 公開日 | 2016-03-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of the nucleosome containing ultraviolet light-induced cyclobutane pyrimidine dimer
Biochem.Biophys.Res.Commun., 471, 2016
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4EVW
 | | Crystal Structure of the nucleoside-diphosphate-sugar pyrophosphorylase from Vibrio cholerae RC9. Northeast Structural Genomics Consortium (NESG) Target VcR193. | | 分子名称: | MAGNESIUM ION, Nucleoside-diphosphate-sugar pyrophosphorylase | | 著者 | Vorobiev, S, Neely, H, Su, M, Seetharaman, J, Mao, M, Xiao, R, Kohan, E, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-04-26 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of the nucleoside-diphosphate-sugar pyrophosphorylase from Vibrio cholerae RC9.
To be Published
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7EA5
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6C0K
 | | Crystal structure of HIV-1 K103N mutant reverse transcriptase in complex with non-nucleoside inhibitor K-5a2 | | 分子名称: | 1,2-ETHANEDIOL, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, DIMETHYL SULFOXIDE, ... | | 著者 | Yang, Y, Nguyen, L.A, Smithline, Z.B, Steitz, T.A. | | 登録日 | 2018-01-01 | | 公開日 | 2018-08-01 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.958 Å) | | 主引用文献 | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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