PDB: 1957 件ウェブページステータス検索Chemie searchBIRD

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6QW0	Structure and function of toscana virus cap snatching endonucleases 分子名称: GLYCEROL, MANGANESE (III) ION, RNA-dependent RNA polymerase, ... 著者 Reguera, J, Jones, R, Bragagniolo, G, Lessoued, S, Mate, M. 登録日 2019-03-05 公開日 2019-09-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure and function of the Toscana virus cap-snatching endonuclease. Nucleic Acids Res., 47, 2019
3LKH	Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides 分子名称: 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide, RNA-directed RNA polymerase 著者 Lesburg, C.A. 登録日 2010-01-27 公開日 2010-03-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. Bioorg.Med.Chem.Lett., 20, 2010
6F5P	A mechanism for the activation of the influenza virus transcriptase 分子名称: ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA, DNA-directed RNA polymerase subunit, MAGNESIUM ION, ... 著者 Serna Martin, I, Grimes, J.M. 登録日 2017-12-02 公開日 2018-09-19 実験手法 X-RAY DIFFRACTION (4.14 Å) 主引用文献 A Mechanism for the Activation of the Influenza Virus Transcriptase. Mol. Cell, 70, 2018
8PM0	Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-06-27 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8QH3	5'vRNA-bound Hantaan virus polymerase in monomeric active state 分子名称: MAGNESIUM ION, RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*A)-3'), RNA-directed RNA polymerase L 著者 Durieux Trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-09-06 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers. Nat Commun, 15, 2024
8QGT	5'vRNA-bound Hantaan virus polymerase in monomeric intermediate state 分子名称: RNA (5'-R(P*UP*AP*GP*UP*AP*GP*UP*AP*GP*AP*CP*A)-3'), RNA-directed RNA polymerase L 著者 Durieux Trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-09-05 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers. Nat Commun, 15, 2024
2BRL	Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 2) 分子名称: 3-CYCLOHEXYL-1-(2-{METHYL[(1-METHYLPIPERIDIN-3-YL)METHYL]AMINO}-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S, Volpari, C, Carfi, A. 登録日 2005-05-06 公開日 2005-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280, 2005
2BRK	Crystal structure of Hepatitis C virus polymerase in complex with an allosteric inhibitor (compound 1) 分子名称: 3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHENYL-1H-INDOLE-6-CARBOXYLIC ACID, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE 著者 Di Marco, S, Volpari, C, Carfi, A. 登録日 2005-05-06 公開日 2005-06-14 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small-Molecule Inhibitors Bound to a Novel Allosteric Site J.Biol.Chem., 280, 2005
3BR9	Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 分子名称: (2R)-2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)propanamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2007-12-21 公開日 2008-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
3BSC	Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 分子名称: 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2007-12-23 公開日 2008-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
3BSA	Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor 分子名称: 2-({3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-(1,3-thiazol-5-yl)-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothia diazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase 著者 Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. 登録日 2007-12-23 公開日 2008-12-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine. Bioorg.Med.Chem.Lett., 18, 2008
3CDE	Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor 分子名称: N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase 著者 Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. 登録日 2008-02-26 公開日 2009-03-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg.Med.Chem.Lett., 18, 2008
6U1X	Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor (3.0 A resolution) 分子名称: Phosphoprotein, RNA-directed RNA polymerase L, ZINC ION 著者 Jenni, S, Bloyet, L.M, Dias-Avalos, R, Liang, B, Wheelman, S.P.J, Grigorieff, N, Harrison, S.C. 登録日 2019-08-17 公開日 2020-01-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep, 30, 2020
3CW4	Large c-terminal domain of influenza a virus RNA-dependent polymerase PB2 分子名称: Polymerase basic protein 2 著者 Kuzuhara, T, Kise, D, Yoshida, H, Horita, T, Murasaki, Y, Utsunomiya, H, Fujiki, H, Tsuge, H. 登録日 2008-04-21 公開日 2009-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue J.Biol.Chem., 284, 2009
5TFR	Crystal structure of Zika Virus NS5 protein 分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Longenecker, K.L, Upadhyay, A.K. 登録日 2016-09-26 公開日 2016-10-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5. Acta Crystallogr F Struct Biol Commun, 73, 2017
6EVJ	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(GDM))-R(P*AP*AP*U)-3'), ... 著者 Pflug, A, Cusack, S. 登録日 2017-11-01 公開日 2017-12-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6EVK	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ... 著者 Pflug, A, Cusack, S. 登録日 2017-11-01 公開日 2017-12-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
6FHI	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker. 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Cusack, S. 登録日 2018-01-14 公開日 2019-01-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published
6FHH	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated. 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Lukarska, M, Cusack, S. 登録日 2018-01-14 公開日 2019-01-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain To Be Published
8P0G	Thogoto virus polymerase in Mode A conformation and bound to 35-mer loop promoter RNA 分子名称: 5'RNA, MAGNESIUM ION, Polymerase acidic protein, ... 著者 Cusack, S, Kouba, T. 登録日 2023-05-10 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Thogoto virus polymerase To Be Published
8P0B	Thogoto virus polymerase in Mode B conformation and bound to 32-mer loop promoter RNA 分子名称: 3'RNA, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Kouba, T. 登録日 2023-05-10 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Thogoto virus polymerase To Be Published
8P0U	Thogoto virus polymerase in Mode B conformation with defined endonuclease domain and bound to 32-mer loop promoter RNA 分子名称: 3'RNA, MAGNESIUM ION, Polymerase acidic protein, ... 著者 Cusack, S, Kouba, T. 登録日 2023-05-10 公開日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.92 Å) 主引用文献 Thogoto virus polymerase To Be Published
4MIA	Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with RG7109 (N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide) 分子名称: N-{4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-2,5-dihydropyridin-3-yl)quinolin-3-yl]phenyl}methanesulfonamide, RNA-directed RNA polymerase, ZINC ION 著者 Harris, S.F, Villasenor, A.G. 登録日 2013-08-30 公開日 2014-05-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. J.Med.Chem., 57, 2014
8R3K	Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A. 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Arragain, B, Cusack, S. 登録日 2023-11-09 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.43 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PNQ	Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, ... 著者 Arragain, B, Cusack, S. 登録日 2023-06-30 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (2.88 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024

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