4C9W

Crystal structure of NUDT1 (MTH1) with R-crizotinib

Summary for 4C9W

Entry DOI	10.2210/pdb4c9w/pdb
Related	4C9X
Descriptor	7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, ... (5 entities in total)
Functional Keywords	hydrolase, crizotinib
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform p18: Cytoplasm. Isoform p26: Cytoplasm: P36639
Total number of polymer chains	1
Total formula weight	19065.69
Authors	Elkins, J.M.,Salah, E.,Huber, K.,Superti-Furga, G.,Abdul Azeez, K.R.,Raynor, J.,Krojer, T.,von Delft, F.,Bountra, C.,Edwards, A.,Knapp, S. (deposition date: 2013-10-03, release date: 2014-04-02, Last modification date: 2023-12-20)
Primary citation	Huber, K.V.M.,Salah, E.,Radic, B.,Gridling, M.,Elkins, J.M.,Stukalov, A.,Jemth, A.,Gokturk, C.,Sanjiv, K.,Stromberg, K.,Pham, T.,Berglund, U.W.,Colinge, J.,Bennett, K.L.,Loizou, J.I.,Helleday, T.,Knapp, S.,Superti-Furga, G. Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy. Nature, 508:222-, 2014 Cited by PubMed: 24695225 DOI: 10.1038/NATURE13194 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation