5AV5
 
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-11 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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9J8M
 | | Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (High mobility complex) | | 分子名称: | Barrier-to-autointegration factor, DNA (193-MER), Histone H2A type 1-B/E, ... | | 著者 | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-08-21 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | | 主引用文献 | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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9J8O
 | | Cryo-EM structure of BAF-Lamin A/C IgF-H1-nucleosome complex | | 分子名称: | Barrier-to-autointegration factor, DNA (193-MER), Histone H1.1, ... | | 著者 | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-08-21 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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9J8N
 | | Cryo-EM structure of BAF-Lamin A/C IgF-nucleosome complex (Low mobility complex) | | 分子名称: | Barrier-to-autointegration factor, DNA (193-MER), Histone H2A type 1-B/E, ... | | 著者 | Horikoshi, N, Miyake, R, Sogawa-Fujiwara, C, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-08-21 | | 公開日 | 2025-02-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (7.14 Å) | | 主引用文献 | Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes.
Nat Commun, 16, 2025
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5AVC
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV6
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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5AV8
 | | human nucleosome core particle | | 分子名称: | DNA (147-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Wakamori, M, Fujii, Y, Umehara, T, Yokoyama, S. | | 登録日 | 2015-06-12 | | 公開日 | 2015-12-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Intra- and inter-nucleosomal interactions of the histone H4 tail revealed with a human nucleosome core particle with genetically-incorporated H4 tetra-acetylation
Sci Rep, 5, 2015
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6UPK
 | | Structure of FACT_subnucleosome complex 1 | | 分子名称: | DNA (79-mer), FACT complex subunit SPT16, FACT complex subunit SSRP1, ... | | 著者 | Zhou, K, Tan, Y.Z, Wei, H, Liu, Y, Carragher, B, Potter, C, Luger, K. | | 登録日 | 2019-10-17 | | 公開日 | 2019-12-11 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
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1OV6
 | | M64V PNP + ALLO | | 分子名称: | 9-(6-DEOXY-BETA-D-ALLOFURANOSYL)-6-METHYLPURINE, PHOSPHATE ION, Purine nucleoside phosphorylase | | 著者 | Ealick, S.E, Bennett, E.M, Anand, R, Secrist, J.A, Parker, P.W, Hassan, A.E, Allan, P.W, McPherson, D.T, Sorscher, E.J. | | 登録日 | 2003-03-25 | | 公開日 | 2004-02-17 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
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6T90
 | | OCT4-SOX2-bound nucleosome - SHL-6 | | 分子名称: | DNA (146-MER), Green fluorescent protein,POU domain, class 5, ... | | 著者 | Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2019-10-25 | | 公開日 | 2020-05-06 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
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2VG5
 | | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | | 分子名称: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-chlorophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | | 著者 | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | | 登録日 | 2007-11-08 | | 公開日 | 2007-12-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors.
Biochem.Biophys.Res.Commun., 365, 2008
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2VG6
 | | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | | 分子名称: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-bromophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | | 著者 | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | | 登録日 | 2007-11-08 | | 公開日 | 2007-12-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors.
Biochem.Biophys.Res.Commun., 365, 2008
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6L49
 | | H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA | | 分子名称: | DNA (485-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Takizawa, Y, Ho, C.-H, Tachiwana, H, Matsunami, H, Ohi, M, Wolf, M, Kurumizaka, H. | | 登録日 | 2019-10-16 | | 公開日 | 2019-12-04 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (18.9 Å) | | 主引用文献 | Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome.
Structure, 28, 2020
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6L4A
 | | H3-H3-H3 tri-nucleosome with the 22 base-pair linker DNA | | 分子名称: | DNA (485-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Takizawa, Y, Ho, C.-H, Tachiwana, H, Matsunami, H, Ohi, M, Wolf, M, Kurumizaka, H. | | 登録日 | 2019-10-16 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (12.3 Å) | | 主引用文献 | Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome.
Structure, 28, 2020
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5AY8
 | | Crystal structure of human nucleosome containing H3.Y | | 分子名称: | CHLORIDE ION, DNA (146-MER), H3.Y, ... | | 著者 | Kujirai, T, Horikoshi, N, Sato, K, Maehara, K, Machida, S, Osakabe, A, Kimura, H, Ohkawa, Y, Kurumizaka, H. | | 登録日 | 2015-08-10 | | 公開日 | 2016-04-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure and function of human histone H3.Y nucleosome
Nucleic Acids Res., 44, 2016
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2VG7
 | | Crystal structures of HIV-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors | | 分子名称: | O-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl] (4-iodophenyl)thiocarbamate, P51 RT, REVERSE TRANSCRIPTASE/RIBONUCLEASE H | | 著者 | Spallarossa, A, Cesarini, S, Ranise, A, Ponassi, M, Unge, T, Bolognesi, M. | | 登録日 | 2007-11-08 | | 公開日 | 2007-12-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | | 主引用文献 | Crystal Structures of HIV-1 Reverse Transcriptase Complexes with Thiocarbamate Non-Nucleoside Inhibitors.
Biochem.Biophys.Res.Commun., 365, 2008
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4C9W
 | | Crystal structure of NUDT1 (MTH1) with R-crizotinib | | 分子名称: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, ... | | 著者 | Elkins, J.M, Salah, E, Huber, K, Superti-Furga, G, Abdul Azeez, K.R, Raynor, J, Krojer, T, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | | 登録日 | 2013-10-03 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy.
Nature, 508, 2014
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1RSZ
 | | Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate | | 分子名称: | 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, Purine nucleoside phosphorylase, SULFATE ION | | 著者 | Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L. | | 登録日 | 2003-12-10 | | 公開日 | 2005-02-22 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
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4C9X
 | | Crystal structure of NUDT1 (MTH1) with S-crizotinib | | 分子名称: | 3-[(1S)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-(1-PIPERIDIN-4-YLPYRAZOL-4-YL)PYRIDIN-2-AMINE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, ... | | 著者 | Elkins, J.M, Salah, E, Huber, K, Superti-Furga, G, Abdul Azeez, K.R, Krojer, T, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | | 登録日 | 2013-10-03 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy.
Nature, 508, 2014
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1RT9
 | | Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate | | 分子名称: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase, SULFATE ION | | 著者 | Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L. | | 登録日 | 2003-12-10 | | 公開日 | 2005-02-22 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
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2M11
 | | Structure of perimidinone-derived synthetic nucleoside paired with guanine in DNA duplex | | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(D3N)P*GP*CP*G)-3') | | 著者 | Kowal, E.A, Lad, R, Pallan, P.S, Muffly, E, Wawrzak, Z, Egli, M, Sturla, S.J, Stone, M.P. | | 登録日 | 2012-11-09 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
Nucleic Acids Res., 41, 2013
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6PWW
 | | Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome | | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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6PWX
 | | Cryo-EM structure of RbBP5 bound to the nucleosome | | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | | 登録日 | 2019-07-23 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Nat Commun, 10, 2019
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8GUK
 | | Human nucleosome core particle (free form) | | 分子名称: | DNA (147-mer), Histone H2A type 1, Histone H2B type 1-J, ... | | 著者 | Onishi, S, Sato, K, Nishizawa, T, Nureki, O, Ogata, K, Sengoku, T. | | 登録日 | 2022-09-12 | | 公開日 | 2023-09-20 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Structure of the human Bre1 complex bound to the nucleosome.
Nat Commun, 15, 2024
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9GMK
 | | SIRT7:H3K18DTU nucleosome complex | | 分子名称: | DNA (148-MER), Histone H2A type 2-A, Histone H2B type 1-J, ... | | 著者 | Moreno-Yruela, C, Ekundayo, B, Foteva, P, Calvino-Sanles, E, Ni, D, Stahlberg, H, Fierz, B. | | 登録日 | 2024-08-29 | | 公開日 | 2025-01-29 | | 最終更新日 | 2025-07-09 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis of SIRT7 nucleosome engagement and substrate specificity.
Nat Commun, 16, 2025
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