2HWE
| A COMPARISON OF THE ANTI-RHINOVIRAL DRUG BINDING POCKET IN HRV14 AND HRV1A | 分子名称: | 5-(5-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLY)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE, HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP1), HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP2), ... | 著者 | Kim, K.H, Rossmann, M.G. | 登録日 | 1994-01-25 | 公開日 | 1994-09-30 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A. J.Mol.Biol., 230, 1993
|
|
7UPH
| Structure of a ribosome with tethered subunits | 分子名称: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | 著者 | Kim, D.S, Watkins, A, Bidstrup, E, Lee, J, Topkar, V.V, Kofman, C, Schwarz, K.J, Liu, Y, Pintilie, G, Roney, E, Das, R, Jewett, M.C. | 登録日 | 2022-04-15 | 公開日 | 2022-08-17 | 最終更新日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Three-dimensional structure-guided evolution of a ribosome with tethered subunits. Nat.Chem.Biol., 18, 2022
|
|
6UNL
| CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2R)-1-(naphthalen-1-yl)-3-{[(2S)-3-(naphthalen-1-yl)-1-oxo-1-{[(pyridin-3-yl)methyl]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2019-10-12 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg.Med.Chem., 28, 2020
|
|
6UNM
| CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(naphthalen-1-yl)-3-{[(2S)-3-(naphthalen-1-yl)-1-oxo-1-{(E)-[2-(pyridin-3-yl)ethylidene]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2019-10-12 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg.Med.Chem., 28, 2020
|
|
5L8R
| The structure of plant photosystem I super-complex at 2.6 angstrom resolution. | 分子名称: | (1R,2S)-4-{(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(4S)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl}-2,5,5-trimethylcyclohex-3-en-1-ol, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ... | 著者 | Mazor, Y, Borovikova, A, Caspy, I, Nelson, N. | 登録日 | 2016-06-08 | 公開日 | 2017-03-15 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of the plant photosystem I supercomplex at 2.6 angstrom resolution. Nat Plants, 3, 2017
|
|
6UNG
| Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(naphthalen-1-yl)-3-{[(2R)-3-oxo-2-(phenylamino)-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I.F. | 登録日 | 2019-10-11 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg.Med.Chem., 28, 2020
|
|
6UNJ
| Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2R)-1-(naphthalen-1-yl)-3-{[(2S)-1-oxo-3-phenyl-1-{[2-(pyridin-3-yl)ethyl]amino}propan-2-yl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2019-10-12 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg.Med.Chem., 28, 2020
|
|
8S54
| RNA polymerase II early elongation complex bound to TFIIE and TFIIF - state b (composite structure) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | 著者 | Zhan, Y, Grabber, F, Oberbeckmann, E, Dienemann, C, Cramer, P. | 登録日 | 2024-02-22 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Three-step mechanism of promoter escape by RNA polymerase II. Mol.Cell, 84, 2024
|
|
5LN3
| The human 26S Proteasome at 6.8 Ang. | 分子名称: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | 著者 | Schweitzer, A, Beck, F, Sakata, E, Unverdorben, P. | 登録日 | 2016-08-03 | 公開日 | 2017-03-22 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol. Cell Proteomics, 16, 2017
|
|
6LQP
| |
2GUS
| Conformational Transition between Four- and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction | 分子名称: | Major outer membrane lipoprotein | 著者 | Liu, J, Zheng, Q, Deng, Y, Kallenbach, N.R, Lu, M. | 登録日 | 2006-05-01 | 公開日 | 2006-07-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Conformational Transition between Four and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction. J.Mol.Biol., 361, 2006
|
|
6LQU
| |
6VLT
| |
6LQS
| |
1T28
| High resolution structure of a picornaviral internal cis-acting replication element | 分子名称: | 34-MER | 著者 | Thiviyanathan, V, Yang, Y, Kaluarachchi, K, Reynbrand, R, Gorenstein, D.G, Lemon, S.M. | 登録日 | 2004-04-20 | 公開日 | 2004-08-10 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | High resolution structure of a picornaviral internal cis-acting replication element(cre). Proc.Natl.Acad.Sci.USA, 101, 2004
|
|
4WNT
| Human Cytochrome P450 2D6 Ajmalicine Complex | 分子名称: | Ajmalicine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Wang, A, Stout, C.D, Johnson, E.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
|
|
4WSX
| The crystal structure of hemagglutinin from A/Jiangxi-Donghu/346/2013 influenza virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain | 著者 | Yang, H, Carney, P.J, Chang, J.C, Villanueva, J.M, Stevens, J. | 登録日 | 2014-10-28 | 公開日 | 2015-02-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure and receptor binding preferences of recombinant hemagglutinins from avian and human h6 and h10 influenza a virus subtypes. J.Virol., 89, 2015
|
|
6WJN
| |
4WNW
| Human Cytochrome P450 2D6 Thioridazine Complex | 分子名称: | 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, Cytochrome P450 2D6, NICKEL (II) ION, ... | 著者 | Wang, A, Stout, C.D, Johnson, E.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.299 Å) | 主引用文献 | Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
|
|
4X6X
| Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative | 分子名称: | 3-{4-[(1-{[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl}piperidin-4-yl)oxy]phenyl}propanoic acid, Bifunctional epoxide hydrolase 2 | 著者 | Chiyo, N, Takai, K, Ishii, T. | 登録日 | 2014-12-09 | 公開日 | 2015-04-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
|
|
4WNV
| Human Cytochrome P450 2D6 Quinine Complex | 分子名称: | Cytochrome P450 2D6, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Wang, A, Stout, C.D, Johnson, E.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
|
|
4WNU
| Human Cytochrome P450 2D6 Quinidine Complex | 分子名称: | Cytochrome P450 2D6, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Wang, A, Stout, C.D, Johnson, E.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding. J.Biol.Chem., 290, 2015
|
|
5H5U
| Mechanistic insights into the alternative translation termination by ArfA and RF2 | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Ma, C, Kurita, D, Li, N, Chen, Y, Himeno, H, Gao, N. | 登録日 | 2016-11-09 | 公開日 | 2017-01-25 | 最終更新日 | 2018-10-24 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanistic insights into the alternative translation termination by ArfA and RF2 Nature, 541, 2017
|
|
5ECJ
| |
6X6C
| Cryo-EM structure of NLRP1-DPP9-VbP complex | 分子名称: | Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ... | 著者 | Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H. | 登録日 | 2020-05-27 | 公開日 | 2021-03-10 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature, 592, 2021
|
|