6VLT
Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Summary for 6VLT
Entry DOI | 10.2210/pdb6vlt/pdb |
Descriptor | Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol, ... (6 entities in total) |
Functional Keywords | cyp2c9*2, cyp2c9 r144c, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 446014.05 |
Authors | Shah, M.B. (deposition date: 2020-01-25, release date: 2020-09-30, Last modification date: 2024-04-03) |
Primary citation | Parikh, S.J.,Evans, C.M.,Obi, J.O.,Zhang, Q.,Maekawa, K.,Glass, K.C.,Shah, M.B. Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism. Mol.Pharmacol., 98:529-539, 2020 Cited by PubMed: 32938720DOI: 10.1124/molpharm.120.000042 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
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