6VLT
Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Cytochrome P450 2C9 | polymer | 476 | 54181.8 | 8 | UniProt (P11712) Pfam (PF00067) In PDB | Homo sapiens (Human) | (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase |
| 2 | G, H, A, B, C... | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 8 | Chemie (HEM) | |||
| 3 | G, H, A, B, C... | [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol | non-polymer | 422.9 | 8 | Chemie (LSN) | |||
| 4 | G, H, E, F | 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE | non-polymer | 494.6 | 8 | Chemie (CM5) | |||
| 5 | G, E, F | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 24 - 490 (UniProt: P11712)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | initiating methionine |
| Ala 20 | - | SEE SEQUENCE DETAILS |
| Lys 21 | - | SEE SEQUENCE DETAILS |
| Lys 22 | - | SEE SEQUENCE DETAILS |
| Thr 23 | - | SEE SEQUENCE DETAILS |
| Cys 144 | Arg 144 | engineered mutation |
| Ile 490 | Val 490 | engineered mutation |
| His 491 | - | SEE SEQUENCE DETAILS |
| His 492 | - | SEE SEQUENCE DETAILS |
| His 493 | - | SEE SEQUENCE DETAILS |
| His 494 | - | SEE SEQUENCE DETAILS |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 433454.1 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 12560.0 | |
| All* | Total formula weight | 446014.1 |
