6VLT
Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Cytochrome P450 2C9 | polymer | 476 | 54181.8 | 8 | UniProt (P11712) Pfam (PF00067) | Homo sapiens (Human) | (R)-limonene 6-monooxygenase,(S)-limonene 6-monooxygenase,(S)-limonene 7-monooxygenase,CYPIIC9,Cholesterol 25-hydroxylase,Cytochrome P-450MP,Cytochrome P450 MP-4,Cytochrome P450 MP-8,Cytochrome P450 PB-1,S-mephenytoin 4-hydroxylase |
| 2 | BA, GA, I, K, M... (G, H, A, B, C...) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 8 | Chemie (HEM) | |||
| 3 | CA, HA, J, L, N... (G, H, A, B, C...) | [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol | non-polymer | 422.9 | 8 | Chemie (LSN) | |||
| 4 | AA, DA, FA, IA, Q... (G, H, E, F) | 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE | non-polymer | 494.6 | 8 | Chemie (CM5) PubChem (58112563) PubChem (44483217) PubChem (46897875) PubChem (70796429) PubChem (70839941) PubChem (70863059) PubChem (59518660) PubChem (68343857) PubChem (89951995) PubChem (73659147) PubChem (5142094) PubChem (5327073) PubChem (92132104) PubChem (126731025) PubChem (126735874) PubChem (133612054) | |||
| 5 | EA, U, Z (G, E, F) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | JA, KA, LA, MA, NA... (A, B, C, D, E...) | water | water | 18.0 | 143 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 24 - 490 (UniProt: P11712)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | initiating methionine |
| Ala 20 | - | SEE SEQUENCE DETAILS |
| Lys 21 | - | SEE SEQUENCE DETAILS |
| Lys 22 | - | SEE SEQUENCE DETAILS |
| Thr 23 | - | SEE SEQUENCE DETAILS |
| Cys 144 | Arg 144 | engineered mutation |
| Ile 490 | Val 490 | engineered mutation |
| His 491 | - | SEE SEQUENCE DETAILS |
| His 492 | - | SEE SEQUENCE DETAILS |
| His 493 | - | SEE SEQUENCE DETAILS |
| His 494 | - | SEE SEQUENCE DETAILS |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 433454.1 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 12560.0 | |
| All* | Total formula weight | 446014.1 |
