6VLT

Crystal Structure of Human P450 2C9*2 Genetic Variant in Complex with Losartan

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008392	molecular_function	arachidonic acid epoxygenase activity
A	0008395	molecular_function	steroid hydroxylase activity
A	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
A	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
A	0016020	cellular_component	membrane
A	0016098	biological_process	monoterpenoid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
A	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
A	0019369	biological_process	arachidonic acid metabolic process
A	0019373	biological_process	epoxygenase P450 pathway
A	0019627	biological_process	urea metabolic process
A	0020037	molecular_function	heme binding
A	0032787	biological_process	monocarboxylic acid metabolic process
A	0034875	molecular_function	caffeine oxidase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043603	biological_process	amide metabolic process
A	0046456	biological_process	icosanoid biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
A	0070330	molecular_function	aromatase activity
A	0070989	biological_process	oxidative demethylation
A	0097267	biological_process	omega-hydroxylase P450 pathway
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008210	biological_process	estrogen metabolic process
B	0008392	molecular_function	arachidonic acid epoxygenase activity
B	0008395	molecular_function	steroid hydroxylase activity
B	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
B	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
B	0016020	cellular_component	membrane
B	0016098	biological_process	monoterpenoid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
B	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
B	0019369	biological_process	arachidonic acid metabolic process
B	0019373	biological_process	epoxygenase P450 pathway
B	0019627	biological_process	urea metabolic process
B	0020037	molecular_function	heme binding
B	0032787	biological_process	monocarboxylic acid metabolic process
B	0034875	molecular_function	caffeine oxidase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043603	biological_process	amide metabolic process
B	0046456	biological_process	icosanoid biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
B	0070330	molecular_function	aromatase activity
B	0070989	biological_process	oxidative demethylation
B	0097267	biological_process	omega-hydroxylase P450 pathway
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008210	biological_process	estrogen metabolic process
C	0008392	molecular_function	arachidonic acid epoxygenase activity
C	0008395	molecular_function	steroid hydroxylase activity
C	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
C	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
C	0016020	cellular_component	membrane
C	0016098	biological_process	monoterpenoid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
C	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
C	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
C	0019369	biological_process	arachidonic acid metabolic process
C	0019373	biological_process	epoxygenase P450 pathway
C	0019627	biological_process	urea metabolic process
C	0020037	molecular_function	heme binding
C	0032787	biological_process	monocarboxylic acid metabolic process
C	0034875	molecular_function	caffeine oxidase activity
C	0042178	biological_process	xenobiotic catabolic process
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043603	biological_process	amide metabolic process
C	0046456	biological_process	icosanoid biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
C	0070330	molecular_function	aromatase activity
C	0070989	biological_process	oxidative demethylation
C	0097267	biological_process	omega-hydroxylase P450 pathway
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006805	biological_process	xenobiotic metabolic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008210	biological_process	estrogen metabolic process
D	0008392	molecular_function	arachidonic acid epoxygenase activity
D	0008395	molecular_function	steroid hydroxylase activity
D	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
D	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
D	0016020	cellular_component	membrane
D	0016098	biological_process	monoterpenoid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
D	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
D	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
D	0019369	biological_process	arachidonic acid metabolic process
D	0019373	biological_process	epoxygenase P450 pathway
D	0019627	biological_process	urea metabolic process
D	0020037	molecular_function	heme binding
D	0032787	biological_process	monocarboxylic acid metabolic process
D	0034875	molecular_function	caffeine oxidase activity
D	0042178	biological_process	xenobiotic catabolic process
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043603	biological_process	amide metabolic process
D	0046456	biological_process	icosanoid biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
D	0070330	molecular_function	aromatase activity
D	0070989	biological_process	oxidative demethylation
D	0097267	biological_process	omega-hydroxylase P450 pathway
E	0004497	molecular_function	monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006805	biological_process	xenobiotic metabolic process
E	0008202	biological_process	steroid metabolic process
E	0008203	biological_process	cholesterol metabolic process
E	0008210	biological_process	estrogen metabolic process
E	0008392	molecular_function	arachidonic acid epoxygenase activity
E	0008395	molecular_function	steroid hydroxylase activity
E	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
E	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
E	0016020	cellular_component	membrane
E	0016098	biological_process	monoterpenoid metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
E	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
E	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
E	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
E	0019369	biological_process	arachidonic acid metabolic process
E	0019373	biological_process	epoxygenase P450 pathway
E	0019627	biological_process	urea metabolic process
E	0020037	molecular_function	heme binding
E	0032787	biological_process	monocarboxylic acid metabolic process
E	0034875	molecular_function	caffeine oxidase activity
E	0042178	biological_process	xenobiotic catabolic process
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0043603	biological_process	amide metabolic process
E	0046456	biological_process	icosanoid biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
E	0070330	molecular_function	aromatase activity
E	0070989	biological_process	oxidative demethylation
E	0097267	biological_process	omega-hydroxylase P450 pathway
F	0004497	molecular_function	monooxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006805	biological_process	xenobiotic metabolic process
F	0008202	biological_process	steroid metabolic process
F	0008203	biological_process	cholesterol metabolic process
F	0008210	biological_process	estrogen metabolic process
F	0008392	molecular_function	arachidonic acid epoxygenase activity
F	0008395	molecular_function	steroid hydroxylase activity
F	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
F	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
F	0016020	cellular_component	membrane
F	0016098	biological_process	monoterpenoid metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
F	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
F	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
F	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
F	0019369	biological_process	arachidonic acid metabolic process
F	0019373	biological_process	epoxygenase P450 pathway
F	0019627	biological_process	urea metabolic process
F	0020037	molecular_function	heme binding
F	0032787	biological_process	monocarboxylic acid metabolic process
F	0034875	molecular_function	caffeine oxidase activity
F	0042178	biological_process	xenobiotic catabolic process
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0043603	biological_process	amide metabolic process
F	0046456	biological_process	icosanoid biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
F	0070330	molecular_function	aromatase activity
F	0070989	biological_process	oxidative demethylation
F	0097267	biological_process	omega-hydroxylase P450 pathway
G	0004497	molecular_function	monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005886	cellular_component	plasma membrane
G	0006805	biological_process	xenobiotic metabolic process
G	0008202	biological_process	steroid metabolic process
G	0008203	biological_process	cholesterol metabolic process
G	0008210	biological_process	estrogen metabolic process
G	0008392	molecular_function	arachidonic acid epoxygenase activity
G	0008395	molecular_function	steroid hydroxylase activity
G	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
G	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
G	0016020	cellular_component	membrane
G	0016098	biological_process	monoterpenoid metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
G	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
G	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
G	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
G	0019369	biological_process	arachidonic acid metabolic process
G	0019373	biological_process	epoxygenase P450 pathway
G	0019627	biological_process	urea metabolic process
G	0020037	molecular_function	heme binding
G	0032787	biological_process	monocarboxylic acid metabolic process
G	0034875	molecular_function	caffeine oxidase activity
G	0042178	biological_process	xenobiotic catabolic process
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0043603	biological_process	amide metabolic process
G	0046456	biological_process	icosanoid biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
G	0070330	molecular_function	aromatase activity
G	0070989	biological_process	oxidative demethylation
G	0097267	biological_process	omega-hydroxylase P450 pathway
H	0004497	molecular_function	monooxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005886	cellular_component	plasma membrane
H	0006805	biological_process	xenobiotic metabolic process
H	0008202	biological_process	steroid metabolic process
H	0008203	biological_process	cholesterol metabolic process
H	0008210	biological_process	estrogen metabolic process
H	0008392	molecular_function	arachidonic acid epoxygenase activity
H	0008395	molecular_function	steroid hydroxylase activity
H	0008404	molecular_function	arachidonic acid 14,15-epoxygenase activity
H	0008405	molecular_function	arachidonic acid 11,12-epoxygenase activity
H	0016020	cellular_component	membrane
H	0016098	biological_process	monoterpenoid metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
H	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
H	0018675	molecular_function	(S)-limonene 6-monooxygenase activity
H	0018676	molecular_function	(S)-limonene 7-monooxygenase activity
H	0019369	biological_process	arachidonic acid metabolic process
H	0019373	biological_process	epoxygenase P450 pathway
H	0019627	biological_process	urea metabolic process
H	0020037	molecular_function	heme binding
H	0032787	biological_process	monocarboxylic acid metabolic process
H	0034875	molecular_function	caffeine oxidase activity
H	0042178	biological_process	xenobiotic catabolic process
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0043603	biological_process	amide metabolic process
H	0046456	biological_process	icosanoid biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0052741	molecular_function	(R)-limonene 6-monooxygenase activity
H	0070330	molecular_function	aromatase activity
H	0070989	biological_process	oxidative demethylation
H	0097267	biological_process	omega-hydroxylase P450 pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue HEM A 501

Chain	Residue
A	ARG97
A	GLN356
A	LEU362
A	SER365
A	HIS368
A	PRO427
A	PHE428
A	SER429
A	ARG433
A	CYS435
A	LSN502
A	ILE112
A	VAL113
A	TRP120
A	ARG124
A	LEU294
A	GLY298
A	THR301
A	THR305

---

site_id	AC2
Number of Residues	11
Details	binding site for residue LSN A 502

Chain	Residue
A	ALA106
A	ARG108
A	ASN204
A	ILE205
A	VAL237
A	MET240
A	VAL292
A	GLU300
A	LEU366
A	PHE476
A	HEM501

---

site_id	AC3
Number of Residues	17
Details	binding site for residue HEM B 501

Chain	Residue
B	ARG97
B	TRP120
B	ARG124
B	LEU294
B	GLY298
B	THR301
B	THR302
B	THR305
B	GLN356
B	LEU362
B	SER365
B	HIS368
B	PHE428
B	SER429
B	ARG433
B	CYS435
B	LSN502

---

site_id	AC4
Number of Residues	10
Details	binding site for residue LSN B 502

Chain	Residue
B	ARG108
B	ASN204
B	ILE205
B	VAL237
B	MET240
B	VAL292
B	GLU300
B	LEU366
B	PHE476
B	HEM501

---

site_id	AC5
Number of Residues	20
Details	binding site for residue HEM C 501

Chain	Residue
C	ARG97
C	ILE112
C	VAL113
C	TRP120
C	ARG124
C	LEU294
C	GLY298
C	THR301
C	THR302
C	THR305
C	GLN356
C	LEU362
C	SER365
C	LEU366
C	HIS368
C	PHE428
C	SER429
C	ARG433
C	CYS435
C	LSN502

---

site_id	AC6
Number of Residues	12
Details	binding site for residue LSN C 502

Chain	Residue
C	ARG108
C	LEU201
C	ASN204
C	ILE205
C	LEU208
C	VAL237
C	MET240
C	VAL292
C	GLU300
C	LEU366
C	PHE476
C	HEM501

---

site_id	AC7
Number of Residues	19
Details	binding site for residue HEM D 501

Chain	Residue
D	LEU362
D	SER365
D	HIS368
D	PRO427
D	PHE428
D	SER429
D	ARG433
D	CYS435
D	LSN502
D	ARG97
D	ILE112
D	VAL113
D	TRP120
D	ARG124
D	LEU294
D	GLY298
D	THR301
D	THR305
D	GLN356

---

site_id	AC8
Number of Residues	13
Details	binding site for residue LSN D 502

Chain	Residue
D	ALA103
D	ARG108
D	LEU201
D	ASN204
D	ILE205
D	LEU208
D	VAL237
D	VAL292
D	GLU300
D	THR301
D	LEU366
D	PHE476
D	HEM501

---

site_id	AC9
Number of Residues	3
Details	binding site for residue CM5 E 501

Chain	Residue
A	PRO227
E	TYR225
E	HOH603

---

site_id	AD1
Number of Residues	21
Details	binding site for residue HEM E 502

Chain	Residue
E	ARG97
E	ILE112
E	VAL113
E	TRP120
E	ARG124
E	LEU294
E	GLY298
E	THR301
E	THR305
E	GLN356
E	LEU362
E	SER365
E	HIS368
E	PRO427
E	PHE428
E	SER429
E	ARG433
E	CYS435
E	GLY437
E	ALA441
E	LSN503

---

site_id	AD2
Number of Residues	11
Details	binding site for residue LSN E 503

Chain	Residue
E	ALA103
E	ARG108
E	LEU201
E	ASN204
E	ILE205
E	LEU208
E	VAL237
E	VAL292
E	GLU300
E	LEU366
E	HEM502

---

site_id	AD3
Number of Residues	8
Details	binding site for residue CM5 E 504

Chain	Residue
A	ASP224
A	TYR225
B	PRO37
E	PRO227
E	GLY228
E	THR229
E	ASN231
E	LYS232

---

site_id	AD4
Number of Residues	1
Details	binding site for residue SO4 E 505

Chain	Residue
E	PRO37

---

site_id	AD5
Number of Residues	3
Details	binding site for residue CM5 F 501

Chain	Residue
C	LYS206
C	THR229
F	TYR225

---

site_id	AD6
Number of Residues	17
Details	binding site for residue HEM F 502

Chain	Residue
F	ARG97
F	ILE112
F	VAL113
F	TRP120
F	ARG124
F	LEU294
F	GLY298
F	THR301
F	GLN356
F	SER365
F	HIS368
F	PRO427
F	PHE428
F	SER429
F	ARG433
F	CYS435
F	LSN503

---

site_id	AD7
Number of Residues	13
Details	binding site for residue LSN F 503

Chain	Residue
F	ALA103
F	ARG108
F	LEU201
F	ASN204
F	ILE205
F	VAL237
F	VAL292
F	ALA297
F	GLU300
F	THR301
F	LEU366
F	PHE476
F	HEM502

---

site_id	AD8
Number of Residues	7
Details	binding site for residue CM5 F 504

Chain	Residue
C	ASP224
C	TYR225
F	PRO227
F	GLY228
F	ASN231
F	LYS232
F	HOH603

---

site_id	AD9
Number of Residues	1
Details	binding site for residue SO4 F 505

Chain	Residue
F	ARG329

---

site_id	AE1
Number of Residues	2
Details	binding site for residue CM5 G 501

Chain	Residue
B	THR229
G	TYR225

---

site_id	AE2
Number of Residues	16
Details	binding site for residue HEM G 502

Chain	Residue
G	ARG97
G	ILE112
G	VAL113
G	TRP120
G	ARG124
G	LEU294
G	THR301
G	GLN356
G	SER365
G	HIS368
G	PRO427
G	PHE428
G	SER429
G	ARG433
G	CYS435
G	LSN503

---

site_id	AE3
Number of Residues	14
Details	binding site for residue LSN G 503

Chain	Residue
G	LEU102
G	ALA103
G	ALA106
G	ARG108
G	LEU201
G	ASN204
G	ILE205
G	LEU208
G	VAL237
G	MET240
G	VAL292
G	GLU300
G	THR301
G	HEM502

---

site_id	AE4
Number of Residues	9
Details	binding site for residue CM5 G 504

Chain	Residue
A	PRO37
B	ASP224
B	TYR225
G	PRO227
G	GLY228
G	THR229
G	ASN231
G	LYS232
G	HOH605

---

site_id	AE5
Number of Residues	1
Details	binding site for residue SO4 G 505

Chain	Residue
G	PRO37

---

site_id	AE6
Number of Residues	3
Details	binding site for residue CM5 H 501

Chain	Residue
D	PRO227
H	TYR225
H	PHE226

---

site_id	AE7
Number of Residues	18
Details	binding site for residue HEM H 502

Chain	Residue
H	ARG97
H	ILE112
H	VAL113
H	TRP120
H	ARG124
H	LEU294
H	GLY298
H	THR301
H	THR305
H	GLN356
H	SER365
H	HIS368
H	PRO427
H	PHE428
H	SER429
H	ARG433
H	CYS435
H	LSN503

---

site_id	AE8
Number of Residues	13
Details	binding site for residue LSN H 503

Chain	Residue
H	ALA103
H	ARG108
H	LEU201
H	ASN204
H	ILE205
H	LEU208
H	VAL237
H	MET240
H	ALA297
H	GLU300
H	LEU366
H	PHE476
H	HEM502

---

site_id	AE9
Number of Residues	8
Details	binding site for residue CM5 H 504

Chain	Residue
C	PRO37
D	ASP224
D	TYR225
H	PRO227
H	GLY228
H	THR229
H	ASN231
H	LYS232

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICVG

Chain	Residue	Details
A	PHE428-GLY437

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: axial binding residue

Chain	Residue	Details
B	CYS435
C	CYS435
D	CYS435
E	CYS435
F	CYS435
G	CYS435
H	CYS435
A	CYS435

---