4X6X

Human soluble epoxide hydrolase in complex with a three substituted cyclopropane derivative

Summary for 4X6X

Entry DOI	10.2210/pdb4x6x/pdb
Related	4X6Y
Descriptor	Bifunctional epoxide hydrolase 2, 3-{4-[(1-{[(1s,2R,3S)-2,3-diphenylcyclopropyl]carbamoyl}piperidin-4-yl)oxy]phenyl}propanoic acid (3 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	78262.02
Authors	Chiyo, N.,Takai, K.,Ishii, T. (deposition date: 2014-12-09, release date: 2015-04-08, Last modification date: 2023-11-08)
Primary citation	Takai, K.,Chiyo, N.,Nakajima, T.,Nariai, T.,Ishikawa, C.,Nakatani, S.,Ikeno, A.,Yamamoto, S.,Sone, T. Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors. Bioorg.Med.Chem.Lett., 25:1705-1708, 2015 Cited by PubMed: 25800114 DOI: 10.1016/j.bmcl.2015.02.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation