7JH7
 
 | | cardiac actomyosin complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | | 著者 | Galkin, V.E, Schroeder, G.F. | | 登録日 | 2020-07-20 | | 公開日 | 2020-10-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex.
Structure, 29, 2021
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8EX5
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8EX6
 | | Human S1P transporter Spns2 in an inward-facing open conformation (state 1*) | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2 | | 著者 | Ahmed, S, Zhao, H, Dai, Y, Lee, C.H. | | 登録日 | 2022-10-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
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8EIT
 | | Structure of FFAR1-Gq complex bound to DHA | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-15 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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6NZ0
 | | Cryo-EM structure of AAV-2 in complex with AAVR PKD domains 1 and 2 | | 分子名称: | Capsid protein VP1, Dyslexia-associated protein KIAA0319-like protein, MAGNESIUM ION | | 著者 | Meyer, N.L, Xie, Q, Davulcu, O, Yoshioka, C, Chapman, M.S. | | 登録日 | 2019-02-12 | | 公開日 | 2019-06-12 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR.
Elife, 8, 2019
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8EJK
 | | Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-17 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJC
 | | Structure of FFAR1-Gq complex bound to TAK-875 | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-16 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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2HRI
 | | A parallel stranded human telomeric quadruplex in complex with the porphyrin TMPyP4 | | 分子名称: | (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3', POTASSIUM ION | | 著者 | Parkinson, G.N, Ghosh, R, Neidle, S. | | 登録日 | 2006-07-20 | | 公開日 | 2007-05-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural basis for binding of porphyrin to human telomeres.
Biochemistry, 46, 2007
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8P0C
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2HRR
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8P0E
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8EX7
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7JG6
 | | Cryo-EM structure of bedaquiline-free Mycobacterium smegmatis ATP synthase rotational state 2 (backbone model) | | 分子名称: | ATP synthase epsilon chain, ATP synthase gamma chain, ATP synthase subunit a, ... | | 著者 | Guo, H, Courbon, G.M, Rubinstein, J.L. | | 登録日 | 2020-07-18 | | 公開日 | 2020-08-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
Nature, 589, 2021
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8EX4
 | | Human S1P transporter Spns2 in an inward-facing open conformation (state 1) | | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Sphingosine-1-phosphate transporter SPNS2 | | 著者 | Ahmed, S, Zhao, H, Dai, Y, Lee, C.H. | | 登録日 | 2022-10-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
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6NYX
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8EX8
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3JWU
 | | Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with N1-{(3'R,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine, ... | | 著者 | Delker, S.L, Li, H, Poulos, T.L. | | 登録日 | 2009-09-18 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
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3JQ7
 | | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-phenylpteridine-2,4,7-triamine (DX2) | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 6-phenylpteridine-2,4,7-triamine, ACETATE ION, ... | | 著者 | Tulloch, L.B, Hunter, W.N. | | 登録日 | 2009-09-06 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
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3JX4
 | | Structure of rat neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with N1-{(3'R,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine, ... | | 著者 | Delker, S.L, Li, H, Poulos, T.L. | | 登録日 | 2009-09-18 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132, 2010
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3JQF
 | | Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5-triazine-2,4,6-triamine (AX2) | | 分子名称: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 1,3,5-triazine-2,4,6-triamine, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... | | 著者 | Tulloch, L.B, Hunter, W.N. | | 登録日 | 2009-09-06 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53, 2010
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7JG5
 | | Cryo-EM structure of bedaquiline-free Mycobacterium smegmatis ATP synthase rotational state 1 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | 著者 | Guo, H, Courbon, G.M, Rubinstein, J.L. | | 登録日 | 2020-07-18 | | 公開日 | 2020-08-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
Nature, 589, 2021
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4TLT
 | | Crystal structure of human transthyretin | | 分子名称: | MAGNESIUM ION, Transthyretin | | 著者 | Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. | | 登録日 | 2014-05-30 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
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2HH8
 | | Solution NMR structure of the ydfO protein from Escherichia coli. Northeast Structural Genomics target ER251. | | 分子名称: | Hypothetical protein ydfO | | 著者 | Rossi, P, Cort, J.R, Ho, C.K, Janjua, H, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Kennedy, M.A, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2006-06-28 | | 公開日 | 2006-08-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of the ydfO protein from Escherichia coli. Northeast Structural Genomics target ER251.
To be Published
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6O2O
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2HHQ
 | | O6-methyl-guanine:T pair in the polymerase-10 basepair position | | 分子名称: | 5'-D(*CP*AP*TP*(6OG)P*CP*GP*AP*GP*TP*CP*AP*GP*G)-3', 5'-D(*GP*CP*CP*TP*GP*AP*CP*TP*CP*GP*TP*AP*TP*GP*A)-3', DNA polymerase I, ... | | 著者 | Warren, J.J, Forsberg, L.J, Beese, L.S. | | 登録日 | 2006-06-28 | | 公開日 | 2006-12-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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