PDB: 10243 件ウェブページステータス検索Chemie searchBIRD

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2PPB	Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin 分子名称: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3'), ... 著者 Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I, Landick, R. 登録日 2007-04-28 公開日 2007-07-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for substrate loading in bacterial RNA polymerase. Nature, 448, 2007
5OHQ	Crystal structure of the KOW6-KOW7 domain of human DSIF 分子名称: CHLORIDE ION, SODIUM ION, Transcription elongation factor SPT5 著者 Bernecky, C, Plitzko, J.M, Cramer, P. 登録日 2017-07-17 公開日 2017-09-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.098 Å) 主引用文献 Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nat. Struct. Mol. Biol., 24, 2017
8JLB	Cryo-EM structure of the 145 bp human nucleosome containing H3.2 C110A mutant 分子名称: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. 登録日 2023-06-02 公開日 2023-10-04 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (2.36 Å) 主引用文献 Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
8JLD	Cryo-EM structure of the 145 bp human nucleosome containing acetylated H3 tail 分子名称: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. 登録日 2023-06-02 公開日 2023-10-04 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (2.48 Å) 主引用文献 Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
2O5J	Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the NTP substrate analog 分子名称: 5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3', 5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3', 5'-R(P*GP*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP*G)-3', ... 著者 Vassylyev, D.G, Vassylyeva, M.N. 登録日 2006-12-06 公開日 2007-07-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for substrate loading in bacterial RNA polymerase. Nature, 448, 2007
6VJS	Escherichia coli RNA polymerase and ureidothiophene-2-carboxylic acid complex 分子名称: 3-{[benzyl(ethyl)carbamoyl]amino}-5-(4-phenoxyphenyl)thiophene-2-carboxylic acid, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Murakami, K.S, Molodtsov, V. 登録日 2020-01-17 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (4.02 Å) 主引用文献 Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus -Based Wound Infection Model in SKH1 Mice. Acs Infect Dis., 6, 2020
3QQC	Crystal structure of archaeal Spt4/5 bound to the RNAP clamp domain 分子名称: DNA-directed RNA polymerase subunit b, DNA-directed RNA polymerase subunit a', DNA-directed RNA polymerase subunit A'', ... 著者 Martinez-Rucobo, F.W. 登録日 2011-02-15 公開日 2011-03-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity. Embo J., 30, 2011
2EC0	RNA-dependent RNA polymerase of foot-and-mouth disease virus in complex with a template-primer RNA and ATP 分子名称: 5'-R(*GP*GP*GP*CP*CP*CP*A)-3', 5'-R(P*AP*UP*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2007-02-09 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
8JL9	Cryo-EM structure of the human nucleosome with scFv 分子名称: DNA (193-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. 登録日 2023-06-02 公開日 2023-10-04 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.65 Å) 主引用文献 Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
8TO6	Escherichia coli RNA polymerase unwinding intermediate (I1d) at the lambda PR promoter 分子名称: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Darst, S.A, Saecker, R.M, Mueller, A.U. 登録日 2023-08-02 公開日 2024-07-03 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 31, 2024
8TOM	Escherichia coli RNA polymerase closed complex intermediate at the lambda PR promoter 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Darst, S.A, Saecker, R.M, Mueller, A.U. 登録日 2023-08-03 公開日 2024-07-03 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 31, 2024
8TOE	Escherichia coli RNA polymerase unwinding intermediate (I1c) at the lambda PR promoter 分子名称: CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Darst, S.A, Saecker, R.M, Mueller, A.U. 登録日 2023-08-03 公開日 2024-07-03 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 31, 2024
8TO1	Escherichia coli RNA polymerase unwinding intermediate (I1a) at the lambda PR promoter 分子名称: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Darst, S.A, Saecker, R.M, Mueller, A.U. 登録日 2023-08-02 公開日 2024-07-03 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 31, 2024
8TO8	Escherichia coli RNA polymerase unwinding intermediate (I1b) at the lambda PR promoter 分子名称: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Darst, S.A, Saecker, R.M, Mueller, A.U. 登録日 2023-08-03 公開日 2024-07-03 最終更新日 2025-06-04 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy. Nat.Struct.Mol.Biol., 31, 2024
4YGX	Crystal Structure of D. melanogaster Ssu72+Symplekin bound to cis peptidomimetic CTD phospho-Ser5 peptide 分子名称: LD40846p, Symplekin, cis peptidomimetic CTD phospho-Ser5 peptide 著者 Mayfield, J.E, Zhang, Y. 登録日 2015-02-26 公開日 2015-09-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II. Acs Chem.Biol., 10, 2015
3AYH	Crystal structure of the C17/25 subcomplex from S. pombe RNA Polymerase III 分子名称: DNA-directed RNA polymerase III subunit rpc8, DNA-directed RNA polymerase III subunit rpc9, SULFATE ION 著者 Ehara, H, Sekine, S, Yokoyama, S. 登録日 2011-05-06 公開日 2011-07-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.193 Å) 主引用文献 Crystal structure of the C17/25 subcomplex from Schizosaccharomyces pombe RNA polymerase III Protein Sci., 20, 2011
1H38	Structure of a T7 RNA polymerase elongation complex at 2.9A resolution 分子名称: 5'-D(*GP*GP*GP*AP*AP*TP*CP*GP*AP*CP *AP*TP*CP*GP*CP*CP*GP*C)-3', 5'-D(*GP*TP*CP*GP*AP*TP*TP*CP*CP*CP)-3', 5'-R(*AP*AP*CP*UP*GP*CP*GP*GP*CP*GP *AP*U)-3', ... 著者 Tahirov, T.H, Temyakov, D, Anikin, M, Patlan, V, McAllister, W.T, Vassylyev, D.G, Yokoyama, S. 登録日 2002-08-24 公開日 2002-11-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of a T7 RNA Polymerase Elongation Complex at 2.9 A Resolution Nature, 420, 2002
8JLA	Cryo-EM structure of the human nucleosome lacking N-terminal region of H2A, H2B, H3, and H4 分子名称: DNA (193-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Oishi, T, Hatazawa, S, Kujirai, T, Kato, J, Kobayashi, Y, Ogasawara, M, Akatsu, M, Takizawa, Y, Kurumizaka, H. 登録日 2023-06-02 公開日 2023-10-04 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Contributions of histone tail clipping and acetylation in nucleosome transcription by RNA polymerase II. Nucleic Acids Res., 51, 2023
7MKP	Escherichia coli RNA polymerase core enzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Qayyum, M.Z, Murakami, K.S. 登録日 2021-04-26 公開日 2021-06-23 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.41 Å) 主引用文献 Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli. J.Biol.Chem., 297, 2021
7MKO	Escherichia coli RNA polymerase elongation complex 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Qayyum, M.Z, Murakami, K.S. 登録日 2021-04-26 公開日 2021-06-02 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Structural basis of RNA polymerase recycling by the Swi2/Snf2 family of ATPase RapA in Escherichia coli. J.Biol.Chem., 297, 2021
1HQM	CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Minakhin, L, Bhagat, S, Brunning, A, Campbell, E.A, Darst, S.A, Ebright, R.H, Severinov, K. 登録日 2000-12-18 公開日 2001-02-07 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly. Proc.Natl.Acad.Sci.USA, 98, 2001
1NB7	HC-J4 RNA polymerase complexed with short RNA template strand 分子名称: 5'-R(*UP*UP*UP*U)-3', MANGANESE (II) ION, polyprotein 著者 O'Farrell, D.J, Trowbridge, R, Rowlands, D.J, Jaeger, J. 登録日 2002-12-02 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J.Mol.Biol., 326, 2003
1YV2	Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a 分子名称: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors J.Biol.Chem., 280, 2005
2A69	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic rifapentin 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-07-02 公開日 2005-09-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005
2A68	Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic rifabutin 分子名称: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... 著者 Artsimovitch, I, Vassylyeva, M.N, Svetlov, D, Svetlov, V, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Tahirov, T.H, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-07-01 公開日 2005-09-20 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell(Cambridge,Mass.), 122, 2005

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