PDB: 1466 件ウェブページステータス検索Chemie searchBIRD

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5KLX	Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 分子名称: 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate, Chimera protein of Ubiquitin-like protein SMT3 and Peptidyl-prolyl cis-trans isomerase, DI(HYDROXYETHYL)ETHER, ... 著者 Fox III, D, Edwards, T.E. 登録日 2016-06-26 公開日 2017-05-31 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 To Be Published
6FDK	Structure of Chlamydia trachomatis effector protein Cdu1 bound to ubiquitin 分子名称: CHLORIDE ION, Deubiquitinase and deneddylase Dub1, Polyubiquitin-B, ... 著者 Ramirez, Y, Kisker, C. 登録日 2017-12-25 公開日 2018-08-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis. ChemMedChem, 13, 2018
5YIJ	Structure of a Legionella effector with substrates 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, SdeA, Ubiquitin 著者 Feng, Y, Mu, Y, Wang, H. 登録日 2017-10-05 公開日 2018-05-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 Structural basis of ubiquitin modification by the Legionella effector SdeA. Nature, 557, 2018
5YMY	The structure of the complex between Rpn13 and K48-diUb 分子名称: Proteasomal ubiquitin receptor ADRM1, Ubiquitin 著者 Liu, Z, Dong, X, Gong, Z, Yi, H.W, Liu, K, Yang, J, Zhang, W.P, Tang, C. 登録日 2017-10-22 公開日 2019-03-13 最終更新日 2019-04-24 実験手法 SOLUTION NMR 主引用文献 Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. Cell Discov, 5, 2019
6FMJ	pVHL:EloB:EloC in complex with (2S,4R)-1-((S)-2-Acetamidopropanethioyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl) benzyl)pyrrolidine-2-carboxamide (ligand 3) 分子名称: (2~{S},4~{R})-1-[(2~{S})-2-acetamidopropanethioyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Soares, P, Lucas, X, Ciulli, A. 登録日 2018-01-31 公開日 2018-04-11 最終更新日 2018-06-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26, 2018
5L6I	Uba1 in complex with Ub-MLN4924 covalent adduct 分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ... 著者 Misra, M, Schindelin, H. 登録日 2016-05-30 公開日 2017-06-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure, 25, 2017
6FYH	Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1 分子名称: E3 ubiquitin-protein ligase HUWE1, Polyubiquitin-B, SULFATE ION, ... 著者 Jaeckl, M, Hartmann, M.D, Wiesner, S. 登録日 2018-03-12 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.906 Å) 主引用文献 beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation. J. Mol. Biol., 430, 2018
6FMK	pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) 分子名称: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... 著者 Soares, P, Lucas, X, Ciulli, A. 登録日 2018-01-31 公開日 2018-04-11 最終更新日 2018-06-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26, 2018
6FNN	Caldiarchaeum Subterraneum Ubiquitin:Rpn11-homolog complex 分子名称: 26S proteasome regulatory subunit N11-like protein, SULFATE ION, Ubiquitin-like protein, ... 著者 Fuchs, A.C.D, Albrecht, R, Martin, J, Hartmann, M.D. 登録日 2018-02-04 公開日 2018-07-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Rpn11-mediated ubiquitin processing in an ancestral archaeal ubiquitination system. Nat Commun, 9, 2018
5L6H	Uba1 in complex with Ub-ABPA3 covalent adduct 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Misra, M, Schindelin, H. 登録日 2016-05-30 公開日 2017-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure, 25, 2017
5KYE	Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018
6FX4	Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C 分子名称: E3 ubiquitin-protein ligase SMURF2, GLYCEROL, Polyubiquitin-B 著者 Jaeckl, M, Holdermann, I, Wiesner, S. 登録日 2018-03-08 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation. J. Mol. Biol., 430, 2018
6NJG	Ubiquitin Variant in Complex with Ubiquitin Interacting Motif 分子名称: Polyubiquitin-B, Vacuolar protein sorting-associated protein 27 著者 Manczyk, N, Sicheri, F. 登録日 2019-01-03 公開日 2019-03-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. Protein Sci., 28, 2019
5ZQ4	PDE-Ubi-ADPr 分子名称: ADENOSINE MONOPHOSPHATE, SidE, ubiquitin 著者 Wang, Y, Gao, A, Gao, P. 登録日 2018-04-17 公開日 2018-05-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.217 Å) 主引用文献 Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 173, 2018
5V1Y	Crystal structure of the ternary RPN13 PRU-RPN2 (940-953)-ubiquitin complex 分子名称: 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin 著者 Hemmis, C.W, VanderLinden, R.T, Yao, T, Robinson, H, Hill, C.P. 登録日 2017-03-02 公開日 2017-05-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.421 Å) 主引用文献 Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. J. Biol. Chem., 292, 2017
5L8H	Structure of USP46-UbVME 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, ZINC ION 著者 Clerici, M, Sixma, T, Dharadhar, S. 登録日 2016-06-07 公開日 2016-09-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. J.Struct.Biol., 196, 2016
5L6J	Uba1 in complex with Ub-MLN7243 covalent adduct 分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ... 著者 Misra, M, Schindelin, H. 登録日 2016-05-30 公開日 2017-06-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Structure, 25, 2017
5KYD	Crystal structure of USP7 catalytic domain [V302K] mutant in complex with ubiquitin 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7 著者 Rouge, L, Ozen, A. 登録日 2016-07-21 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation. Structure, 26, 2018
6GFX	pVHL:EloB:EloC in complex with modified HIF-1a CODD peptide containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 13a) 分子名称: Elongin-B, Elongin-C, FLUORINATED HYPOXIA-INDUCIBLE FACTOR 1 ALPHA PEPTIDE, ... 著者 Castro, G.V, Testa, A, Ciulli, A. 登録日 2018-05-02 公開日 2018-07-11 最終更新日 2018-08-01 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140, 2018
5TR4	Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243 分子名称: Ubiquitin, Ubiquitin-activating enzyme E1 1, [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate 著者 Sintchak, M.D. 登録日 2016-10-25 公開日 2017-11-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243) To be published
6GFZ	pVHL:EloB:EloC in complex with modified VH032 containing (3S,4S)-3-fluoro-4-hydroxyproline (ligand 14b) 分子名称: (2~{R},3~{S},4~{S})-1-[(2~{S})-2-acetamido-3,3-dimethyl-butanoyl]-3-fluoranyl-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... 著者 Gadd, M.S, Testa, A, Ciulli, A. 登録日 2018-05-02 公開日 2018-07-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140, 2018
5ZQ3	PDE-Ubiquitin 分子名称: SidE, Ubiquitin 著者 Wang, Y, Gao, A, Gao, P. 登録日 2018-04-17 公開日 2018-05-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.182 Å) 主引用文献 Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE. Cell, 173, 2018
6N6R	Crystal structure of ABIN-1 UBAN in complex with two M1-linked di-ubiquitins 分子名称: TNFAIP3-interacting protein 1, Ubiquitin 著者 Rahighi, S, Dikic, I, Wakatsuki, S. 登録日 2018-11-27 公開日 2019-07-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J.Mol.Biol., 431, 2019
5LN1	STRUCTURE OF UBIQUITYLATED-RPN10 FROM YEAST; 分子名称: 26S proteasome regulatory subunit RPN10, Polyubiquitin-B 著者 Keren-Kaplan, T, Attali, I, Levin-Kravets, O, Prag, G. 登録日 2016-08-02 公開日 2016-10-19 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism. Nat Commun, 7, 2016
6FFA	FMDV Leader protease bound to substrate ISG15 分子名称: GLYCEROL, Lbpro, SULFATE ION, ... 著者 Swatek, K.N, Pruneda, J.N, Komander, D. 登録日 2018-01-05 公開日 2018-02-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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