6UKV

STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 9

Summary for 6UKV

• Entry DOI: 10.2210/pdb6ukv/pdb
• Descriptor: fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain, 4-[6-(3-{[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-5-yl]oxy}propoxy)-5-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid (3 entities in total)
• Functional Keywords: agonist, sting (stimulator of interferon genes), transmembrane protein 173 (tmem173), immune system, immune system-inhibitor complex, immune system-agonist complex
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 2
• Total formula weight: 70114.37

Authors

Lesburg, C.A. (deposition date: 2019-10-06, release date: 2020-08-19, Last modification date: 2023-10-11)

• Primary citation: Pan, B.S.,Perera, S.A.,Piesvaux, J.A.,Presland, J.P.,Schroeder, G.K.,Cumming, J.N.,Trotter, B.W.,Altman, M.D.,Buevich, A.V.,Cash, B.,Cemerski, S.,Chang, W.,Chen, Y.,Dandliker, P.J.,Feng, G.,Haidle, A.,Henderson, T.,Jewell, J.,Kariv, I.,Knemeyer, I.,Kopinja, J.,Lacey, B.M.,Laskey, J.,Lesburg, C.A.,Liang, R.,Long, B.J.,Lu, M.,Ma, Y.,Minnihan, E.C.,O'Donnell, G.,Otte, R.,Price, L.,Rakhilina, L.,Sauvagnat, B.,Sharma, S.,Tyagarajan, S.,Woo, H.,Wyss, D.F.,Xu, S.,Bennett, D.J.,Addona, G.H.; An orally available non-nucleotide STING agonist with antitumor activity.; Science, 369:-, 2020; PubMed: 32820094; DOI: 10.1126/science.aba6098

Experimental method

X-RAY DIFFRACTION (1.83 Å)