6UKV
STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000794 | cellular_component | condensed nuclear chromosome |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005940 | cellular_component | septin ring |
| A | 0016925 | biological_process | protein sumoylation |
| A | 0031386 | molecular_function | protein tag activity |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
| B | 0000794 | cellular_component | condensed nuclear chromosome |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005940 | cellular_component | septin ring |
| B | 0016925 | biological_process | protein sumoylation |
| B | 0031386 | molecular_function | protein tag activity |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue QB1 A 401 |
| Chain | Residue |
| A | SER162 |
| A | HOH508 |
| A | HOH522 |
| A | HOH533 |
| A | HOH541 |
| B | SER162 |
| B | TYR163 |
| B | TYR167 |
| B | ARG238 |
| B | THR263 |
| B | PRO264 |
| A | TYR163 |
| B | QB1401 |
| B | HOH526 |
| A | GLY166 |
| A | TYR167 |
| A | ARG232 |
| A | ILE235 |
| A | ARG238 |
| A | THR263 |
| A | HOH504 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue QB1 B 401 |
| Chain | Residue |
| A | SER162 |
| A | TYR163 |
| A | TYR167 |
| A | ARG238 |
| A | THR263 |
| A | PRO264 |
| A | QB1401 |
| A | HOH504 |
| A | HOH508 |
| A | HOH522 |
| A | HOH533 |
| A | HOH541 |
| B | SER162 |
| B | TYR163 |
| B | GLY166 |
| B | TYR167 |
| B | ARG232 |
| B | ILE235 |
| B | ARG238 |
| B | THR263 |
| B | HOH526 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:17330950 |
| Chain | Residue | Details |
| A | SER51 | |
| B | SER51 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
| Chain | Residue | Details |
| A | SER53 | |
| B | SER53 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| A | GLY147 | |
| B | GLY147 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 |
| Chain | Residue | Details |
| A | LYS338 | |
| B | LYS338 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y |
| Chain | Residue | Details |
| A | SER162 | |
| B | SER162 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | TYR167 | |
| B | TYR167 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX |
| Chain | Residue | Details |
| A | ARG238 | |
| B | ARG238 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | THR263 | |
| B | THR263 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | THR229 | |
| B | THR229 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | SER241 | |
| B | SER241 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 |
| Chain | Residue | Details |
| A | LYS236 | |
| B | LYS236 |
