1EN4
| CRYSTAL STRUCTURE ANALYSIS OF THE E. COLI MANGANESE SUPEROXIDE DISMUTASE Q146H MUTANT | 分子名称: | MANGANESE (II) ION, MANGANESE SUPEROXIDE DISMUTASE | 著者 | Edwards, R.A, Whittaker, M.M, Baker, E.N, Whittaker, J.W, Jameson, G.B. | 登録日 | 2000-03-20 | 公開日 | 2001-06-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Outer sphere mutations perturb metal reactivity in manganese superoxide dismutase. Biochemistry, 40, 2001
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3LXC
| Interconversion of Human Lysosomal Enzyme Specificities | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, GLYCEROL, ... | 著者 | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | 登録日 | 2010-02-25 | 公開日 | 2010-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
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1EBF
| HOMOSERINE DEHYDROGENASE FROM S. CEREVISIAE COMPLEX WITH NAD+ | 分子名称: | HOMOSERINE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION | 著者 | DeLaBarre, B, Thompson, P.R, Wright, G.D, Berghuis, A.M. | 登録日 | 2000-01-24 | 公開日 | 2000-03-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nat.Struct.Biol., 7, 2000
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6WML
| Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod) | 分子名称: | (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Appleby, T.C, Perry, J.K, Mish, M, Villasenor, A.G, Mackman, R.L. | 登録日 | 2020-04-21 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J.Med.Chem., 63, 2020
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1RHY
| Crystal structure of Imidazole Glycerol Phosphate Dehydratase | 分子名称: | ACETIC ACID, ETHYL MERCURY ION, GLYCEROL, ... | 著者 | Sinha, S.C, Chaudhuri, B.N, Burgner, J.W, Yakovleva, G, Davisson, V.J, Smith, J.L. | 登録日 | 2003-11-14 | 公開日 | 2004-05-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of imidazole glycerol-phosphate dehydratase: duplication of an unusual fold J.Biol.Chem., 279, 2004
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4KEM
| Crystal structure of a tartrate dehydratase from azospirillum, target efi-502395, with bound mg and a putative acrylate ion, ordered active site | 分子名称: | ACRYLIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Vetting, M.W, Wichelecki, D, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Hillerich, B, Love, J, Seidel, R.D, Imker, H.J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | 登録日 | 2013-04-25 | 公開日 | 2013-05-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Crystal structure of a tartrate dehydratase from azospirillum, target efi-502395, with bound mg and a putative acrylate ion, ordered active site To be Published
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1E55
| Crystal structure of the inactive mutant Monocot (Maize ZMGlu1) beta-glucosidase ZMGluE191D in complex with the competitive inhibitor dhurrin | 分子名称: | (2S)-HYDROXY(4-HYDROXYPHENYL)ETHANENITRILE, BETA-GLUCOSIDASE, beta-D-glucopyranose | 著者 | Czjzek, M, Cicek, M, Bevan, D.R, Zamboni, V, Henrissat, B, Esen, A. | 登録日 | 2000-07-18 | 公開日 | 2000-12-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The mechanism of substrate (aglycone) specificity in beta-glucosidases is revealed by crystal structures of mutant maize beta-glucosidase-DIMBOA, -DIMBOAGlc, and -dhurrin complexes. Proc. Natl. Acad. Sci. U.S.A., 97, 2000
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7MO6
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1EK1
| CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CIU INHIBITOR | 分子名称: | EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA | 著者 | Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W. | 登録日 | 2000-03-06 | 公開日 | 2000-05-31 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. J.Biol.Chem., 275, 2000
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7MH6
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7MOM
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2YL8
| Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose, BETA-N-ACETYLHEXOSAMINIDASE, ... | 著者 | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | 登録日 | 2011-05-31 | 公開日 | 2011-09-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis. Structure, 19, 2011
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7MGX
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1RPQ
| High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Stamos, J, Eigenbrot, C, Nakamura, G.R, Reynolds, M.E, Yin, J.P, Lowman, H.B, Fairbrother, W.J, Starovasnik, M.A. | 登録日 | 2003-12-03 | 公開日 | 2004-07-20 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Convergent Recognition of the IgE Binding Site on the High-Affinity IgE Receptor. Structure, 12, 2004
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5WI4
| CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH ARHGEF2 | 分子名称: | Dynein light chain Tctex-type 1,Rho guanine nucleotide exchange factor 2, SULFATE ION | 著者 | Balan, M, Ishiyama, N, Marshall, C.B, Ikura, M. | 登録日 | 2017-07-18 | 公開日 | 2017-11-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity. Sci Signal, 10, 2017
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6WT4
| Structure of a bacterial STING receptor from Flavobacteriaceae sp. in complex with 3',3'-cGAMP | 分子名称: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Bacterial STING, SULFATE ION | 著者 | Morehouse, B.R, Govande, A.A, Millman, A, Keszei, A.F.A, Lowey, B, Ofir, G, Shao, S, Sorek, R, Kranzusch, P.J. | 登録日 | 2020-05-01 | 公開日 | 2020-09-09 | 最終更新日 | 2020-10-28 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | STING cyclic dinucleotide sensing originated in bacteria. Nature, 586, 2020
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4KGK
| Bacterial tRNA(HIS) Guanylyltransferase (Thg1)-Like Protein in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Thg1-like uncharacterized protein | 著者 | Hyde, S.J, Rao, B.S, Eckenroth, B.E, Jackman, J.E, Doublie, S. | 登録日 | 2013-04-29 | 公開日 | 2013-08-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural Studies of a Bacterial tRNA(HIS) Guanylyltransferase (Thg1)-Like Protein, with Nucleotide in the Activation and Nucleotidyl Transfer Sites. Plos One, 8, 2013
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1EJ0
| FTSJ RNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLMETHIONINE, MERCURY DERIVATIVE | 分子名称: | FTSJ, MERCURY (II) ION, S-ADENOSYLMETHIONINE | 著者 | Bugl, H, Fauman, E.B, Staker, B.L, Zheng, F, Kushner, S.R, Saper, M.A, Bardwell, J.C.A, Jakob, U. | 登録日 | 2000-02-29 | 公開日 | 2000-08-30 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | RNA methylation under heat shock control. Mol.Cell, 6, 2000
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2YL5
| Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis | 分子名称: | 1,2-ETHANEDIOL, BETA-N-ACETYLHEXOSAMINIDASE, MAGNESIUM ION | 著者 | Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. | 登録日 | 2011-05-31 | 公開日 | 2011-09-14 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis. Structure, 19, 2011
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5WN8
| Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1 | 分子名称: | Indoleamine 2,3-dioxygenase 1, N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lewis-Ballester, A, Pham, K.N, Batabyal, D, Karkashon, S, Bonanno, J.B, Poulos, T.L, Yeh, S.R. | 登録日 | 2017-07-31 | 公開日 | 2017-12-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1. Nat Commun, 8, 2017
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6X5R
| Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A2-Asn | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A2-Asn, ... | 著者 | Kadirvelraj, R, Wood, Z.A. | 登録日 | 2020-05-26 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases. J.Biol.Chem., 295, 2020
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1EO4
| ECORV BOUND TO MN2+ AND COGNATE DNA CONTAINING A 3'S SUBSTITION AT THE CLEAVAGE SITE | 分子名称: | ACETIC ACID, DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), MANGANESE (II) ION, ... | 著者 | Horton, N.C, Connolly, B.A, Perona, J.J. | 登録日 | 2000-03-21 | 公開日 | 2000-04-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study J.Am.Chem.Soc., 122, 2000
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5W7C
| Human acyloxyacyl hydrolase (AOAH), proteolytically processed, S263A mutant, with LPS | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-HYDROXY-TETRADECANOIC ACID, ... | 著者 | Gorelik, A, Illes, K, Nagar, B. | 登録日 | 2017-06-19 | 公開日 | 2018-01-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Crystal structure of the mammalian lipopolysaccharide detoxifier. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1ESL
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1E60
| OXIDIZED DMSO REDUCTASE EXPOSED TO HEPES - Structure II BUFFER | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, Dimethyl sulfoxide/trimethylamine N-oxide reductase, MOLYBDENUM (IV)OXIDE, ... | 著者 | Bailey, S, Bennett, B, Adams, B, Smith, A.T, Bray, R.C. | 登録日 | 2000-08-06 | 公開日 | 2000-08-25 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Reversible Dissociation of Thiolate Ligands from Molybdenum in an Enzyme of the Dimethyl Sulfoxide Reductase Family Biochemistry, 39, 2000
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