PDB: 36840 件ウェブページステータス検索Chemie searchBIRD

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6AQ1	The crystal structure of human FABP3 分子名称: Fatty acid-binding protein, heart, PALMITIC ACID, ... 著者 Hsu, H.C, Li, H. 登録日 2017-08-18 公開日 2018-06-13 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.40000093 Å) 主引用文献 SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. Eur J Med Chem, 154, 2018
6E8H	Legionella Longbeachae LeSH (Llo2327) 分子名称: CHLORIDE ION, LeSH (Llo2327) 著者 Kaneko, T, Li, S.S.C. 登録日 2018-07-29 公開日 2018-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
6B6R	Orthorhombic trypsin cryocooled to 100 K with 50% mpd as cryoprotectant 分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, BENZAMIDINE, CALCIUM ION, ... 著者 Juers, D.H. 登録日 2017-10-03 公開日 2017-11-01 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.00005865 Å) 主引用文献 The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order. Acta Crystallogr D Struct Biol, 74, 2018
6EIS	DYRK1A in complex with JWC-055 分子名称: 1-[4-fluoranyl-2-(trifluoromethyl)phenyl]-9-(1~{H}-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A 著者 Rothweiler, U. 登録日 2017-09-19 公開日 2018-08-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
6E94	Crystal Structure of ZBTB38 C-terminal Zinc Fingers 6-9 K1055R in complex with methylated DNA 分子名称: DNA (5'-D(*GP*CP*AP*CP*TP*CP*AP*TP*(DCM)P*GP*GP*(DCM)P*GP*CP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*GP*(DCM)P*GP*CP*(DCM)P*GP*AP*TP*GP*AP*GP*TP*GP*C)-3'), ZINC ION, ... 著者 Hudson, N.O, Whitby, F.G, Buck-Koehntop, B.A. 登録日 2018-07-31 公開日 2018-11-07 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Structural insights into methylated DNA recognition by the C-terminal zinc fingers of the DNA reader protein ZBTB38. J. Biol. Chem., 293, 2018
6B77	Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XII, GLYCEROL, ... 著者 Dementiev, A.A, Silva, A, Yee, C, Flavin, M.T, Partridge, J.R. 登録日 2017-10-03 公開日 2018-03-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors. Blood Adv, 2, 2018
6E9L	Crystal structure of Protein Kinase A in complex with the PKI peptide and a pyridinylbenzamide based inhibitor 分子名称: N-[(2,3-dihydro-1,4-benzodioxin-5-yl)methyl]-4-(pyridin-4-yl)benzamide, PKI peptide, cAMP-dependent protein kinase catalytic subunit alpha 著者 Judge, R.A, Hobson, A.D. 登録日 2018-08-01 公開日 2018-11-14 最終更新日 2019-01-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure Based Drug Design. J. Med. Chem., 61, 2018
5W7T	STRUCTURE OF PHOSPHORYLATED WNK1 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase WNK1 著者 JIOU, J, CHLEBOWICZ, J, AKELLA, R, GOLDSMITH, E.J. 登録日 2017-06-20 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 STRUCTURE OF PHOSPHORYLATED WNK1 To Be Published
4PRF	A Second Look at the HDV Ribozyme Structure and Dynamics. 分子名称: Hepatitis Delta virus ribozyme, STRONTIUM ION, U1 small nuclear ribonucleoprotein A 著者 Kapral, G.J, Jain, S, Noeske, J, Doudna, J.A, Richardson, D.C, Richardson, J.S. 登録日 2014-03-05 公開日 2014-10-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.395 Å) 主引用文献 New tools provide a second look at HDV ribozyme structure, dynamics and cleavage. Nucleic Acids Res., 42, 2014
6LNM	Crystal structure of CASK-CaMK in complex with Mint1-CID 分子名称: Amyloid-beta A4 precursor protein-binding family A member 1, Peripheral plasma membrane protein CASK 著者 Cai, Q, Zhang, M. 登録日 2019-12-31 公開日 2020-04-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for the High-Affinity Interaction between CASK and Mint1. Structure, 28, 2020
4PRU	Crystal structure of dimethyllysine hen egg-white lysozyme in complex with sclx4 at 2.2 A resolution 分子名称: 25,26,27,28-tetrahydroxypentacyclo[19.3.1.1~3,7~.1~9,13~.1~15,19~]octacosa-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-dodecaene-5,11,17,23-tetrasulfonic acid, GLYCEROL, Lysozyme C 著者 McGovern, R.E, Lyons, J.A, Crowley, P.B. 登録日 2014-03-06 公開日 2014-11-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural study of a small molecule receptor bound to dimethyllysine in lysozyme. Chem Sci, 6, 2015
6EKG	Crystal structure of an archaeal CheY from Methanoccocus maripaludis 分子名称: Chemotaxis protein CheY, MAGNESIUM ION 著者 Altegoer, F, Bange, G. 登録日 2017-09-26 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structure and function of the archaeal response regulator CheY. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5ZC1	X-ray diffraction analysis of the CsStefin-1 分子名称: Cystatin-1 著者 Jang, S.B, Park, S.Y. 登録日 2018-02-14 公開日 2018-12-26 実験手法 X-RAY DIFFRACTION (2.302708 Å) 主引用文献 Structural basis of the cystein protease inhibitor Clonorchis sinensis Stefin-1. Biochem. Biophys. Res. Commun., 498, 2018
6LKR	Crystal structure of mouse DCAR2 CRD domain complex 分子名称: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, C-type lectin domain family 4, member b1, ... 著者 Omahdi, Z, Horikawa, Y, Toyonaga, K, Kakuta, Y, Yamasaki, S. 登録日 2019-12-20 公開日 2020-03-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR. J.Biol.Chem., 295, 2020
5ZC6	Solution structure of H-RasT35S mutant protein in complex with KBFM123 分子名称: 3-oxidanyl-~{N}-[[(2~{R})-oxolan-2-yl]methyl]naphthalene-2-carboxamide, GTPase HRas, MAGNESIUM ION, ... 著者 Matsumoto, S, Hayashi, Y, Hiraga, T, Matsuo, K, Kataoka, T. 登録日 2018-02-15 公開日 2018-09-12 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring Biochemistry, 57, 2018
6EOC	Crystal structure of AMPylated GRP78 in apo form (Crystal form 2) 分子名称: 78 kDa glucose-regulated protein, CITRATE ANION, SULFATE ION 著者 Yan, Y, Preissler, S, Ron, D, Read, R.J. 登録日 2017-10-09 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation. Elife, 6, 2017
6ERU	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compound RKp120 分子名称: UPF0418 protein FAM164A, cAMP-dependent protein kinase catalytic subunit alpha 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-19 公開日 2018-10-31 最終更新日 2020-07-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6LXJ	Crystal structure of human Z2B3 Fab in complex with influenza virus neuraminidase from A/Anhui/1/2013 (H7N9) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Heavy chain of Z2B3 Fab, ... 著者 Jiang, H, Peng, W, Qi, J, Chai, Y, Song, H, Shi, Y, Gao, G.F, Wu, Y. 登録日 2020-02-11 公開日 2020-12-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.903 Å) 主引用文献 Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. Mbio, 11, 2020
5ZEO	X-ray structure of sperm whale V21C/V66C/F46S myoglobin mutant with an intramolecular disulfide bond 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Yuan, H. 登録日 2018-02-27 公開日 2018-05-09 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Regulation of both the structure and function by a de novo designed disulfide bond: a case study of heme proteins in myoglobin Chem. Commun. (Camb.), 54, 2018
4PEP	THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION 分子名称: PEPSIN 著者 Andreeva, N, Fedorov, A.A, Sielecki, A, James, M. 登録日 1989-12-18 公開日 1990-04-15 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution. J.Mol.Biol., 214, 1990
6E6P	HRAS G13D bound to GppNHp (Ha,b,c13GNP) 分子名称: CALCIUM ION, GLYCEROL, GTPase HRas, ... 著者 Johnson, C.W, Mattos, C. 登録日 2018-07-25 公開日 2019-07-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28, 2019
5V9O	KRAS G12C inhibitor 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Westover, K, Lu, J. 登録日 2017-03-23 公開日 2017-08-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol, 24, 2017
8GGI	Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #1 of 20) 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2023-03-08 公開日 2024-03-06 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
7VLJ	Crystal structure of Entamoeba histolytica serine protease inhibitor, Histopin, in the cleaved conformation 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, POTASSIUM ION, ... 著者 Ali, M.F, Devi, S, Gourinath, S. 登録日 2021-10-03 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Crystal structure of Entamoeba histolytica serine protease inhibitor, Histopin, in the cleaved conformation To Be Published
8GGJ	Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #2 of 20) 分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor 著者 Papasergi-Scott, M.M, Skiniotis, G. 登録日 2023-03-08 公開日 2024-03-06 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024

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