5ZEO

X-ray structure of sperm whale V21C/V66C/F46S myoglobin mutant with an intramolecular disulfide bond

Summary for 5ZEO

Entry DOI	10.2210/pdb5zeo/pdb
Descriptor	Myoglobin, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywords	myoglobin, sperm whale, oxygen transport
Biological source	Physeter catodon (Sperm whale)
Total number of polymer chains	1
Total formula weight	17799.37
Authors	Yuan, H. (deposition date: 2018-02-27, release date: 2018-05-09, Last modification date: 2024-10-09)
Primary citation	Yin, L.L.,Yuan, H.,Du, K.J.,He, B.,Gao, S.Q.,Wen, G.B.,Tan, X.,Lin, Y.W. Regulation of both the structure and function by a de novo designed disulfide bond: a case study of heme proteins in myoglobin Chem. Commun. (Camb.), 54:4356-4359, 2018 Cited by PubMed Abstract: A de novo designed intramolecular disulfide bond in myoglobin, resembling that in cytoglobin without structural evidence, was confirmed by an X-ray structure for the first time and was demonstrated to regulate both the structure and function of this protein, which fulfills the design of an artificial dehaloperoxidase, with an activity exceeding that of a native enzyme. PubMed: 29645029 DOI: 10.1039/c8cc01646a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation