PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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8DSH	Human NAMPT in complex with quercitrin and AMPcP 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DSE	Human NAMPT in complex with substrate NAM and activator quercitrin 分子名称: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside, CHLORIDE ION, NICOTINAMIDE, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.428 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DTJ	Human NAMPT in complex with small molecule activator ZN-43-S 分子名称: (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-{2-[4-(trifluoromethyl)phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-25 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.118 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
8DSI	Human NAMPT in complex with substrate NAM 分子名称: CHLORIDE ION, GLYCEROL, NICOTINAMIDE, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry, 62, 2023
3QEW	RB69 DNA Polymerase (L561A/S565G/Y567A) Ternary Complex with dDTP Opposite dT 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3'), ... 著者 Xia, S, Konigsberg, W.H, Wang, J. 登録日 2011-01-20 公開日 2012-01-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Hydrogen-Bonding Capability of Difluorotoluene Nucleoside in Replication Complexes To be Published
8DNH	Cryo-EM structure of nonmuscle beta-actin 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Arora, A.S, Huang, H.L, Heissler, S.M, Chinthalapudi, K. 登録日 2022-07-11 公開日 2023-04-12 実験手法 ELECTRON MICROSCOPY (2.99 Å) 主引用文献 Structural insights into actin isoforms. Elife, 12, 2023
8E3K	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAGCGGAAGTGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-17 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
8E5Y	Human PU.1 ETS-Domain Bound to d(AATAAGCGGAAGTGGG) Acetate Free at pH 5.4 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), SODIUM ION, ... 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-22 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
8EE9	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAAAGGAATGGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*AP*AP*GP*GP*AP*AP*TP*GP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*CP*AP*TP*TP*CP*CP*TP*TP*TP*TP*AP*T)-3'), Transcription factor PU.1 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-09-06 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
6AVS	Complex structure of JMJD5 and Symmetric Monomethyl-Arginine (MMA) 分子名称: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, Lysine-specific demethylase 8, ZINC ION 著者 Lee, S, Liu, H, Wang, Y, Dai, S, Zhang, G. 登録日 2017-09-04 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep, 8, 2018
8EBH	Human PU.1 ETS-Domain (165-270) Bound to d(AATAAGCGGAATGGGG) 分子名称: DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*TP*GP*GP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*CP*CP*AP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3'), Transcription factor PU.1 著者 Terrell, J.R, Poon, G.M.K. 登録日 2022-08-31 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 DNA selection by the master transcription factor PU.1. Cell Rep, 42, 2023
8EDG	Cryo-EM structure of the Hermes transposase bound to two left-ends of its DNA transposon 分子名称: DNA (46-MER), DNA (5'-D(*GP*CP*GP*TP*GP*AP*A)-3'), DNA (55-MER), ... 著者 Lannes, L, Dyda, F. 登録日 2022-09-04 公開日 2023-08-02 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (4.64 Å) 主引用文献 Zinc-finger BED domains drive the formation of the active Hermes transpososome by asymmetric DNA binding. Nat Commun, 14, 2023
8DSM	Human NAMPT in complex with inhibitor ZN-4-3 分子名称: (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide, CHLORIDE ION, GLYCEROL, ... 著者 Ratia, K, Xiong, R, Shen, Z, Thatcher, G.R. 登録日 2022-07-22 公開日 2023-08-02 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 A structural mechanism for positive allosteric modulation of nicotinamide phosphoribosyltransferase to elevate cellular NAD+ To Be Published
5O9B	Solution NMR structure of human GATA2 C-terminal zinc finger domain 分子名称: Endothelial transcription factor GATA-2, ZINC ION 著者 Nurmohamed, S.S, Broadhurst, R.W, May, G, Enver, T. 登録日 2017-06-16 公開日 2019-02-06 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Solution NMR structure of human GATA2 C-terminal zinc finger domain To Be Published
8E67	ETV6 H396Y variant bound to DNA containing the sequence GGAT 分子名称: Complementary 15 bp strand, GGAT-containing 15 bp DNA, Transcription factor ETV6 著者 Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. 登録日 2022-08-22 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The functional role of histidine within the ETV6 ETS domain to be published
8E66	ETV6 H396Y variant bound to DNA containing the sequence GGAA 分子名称: CACODYLATE ION, Complementary 15 bp strand, GGAA-containing 15 bp DNA, ... 著者 Scheu, K, Chan, A.C, Murphy, M.E, McIntosh, L.P. 登録日 2022-08-22 公開日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The functional role of histidine within the ETV6 ETS domain to be published
3JZH	EED-H3K79me3 分子名称: HISTONE PEPTIDE, Polycomb protein EED 著者 Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-23 公開日 2009-12-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
6ANU	Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain 分子名称: Actin, cytoplasmic 1, Spectrin beta chain, ... 著者 Wang, F, Orlova, A, Avery, A.W, Hays, T.S, Egelman, E.H. 登録日 2017-08-14 公開日 2017-11-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Structural basis for high-affinity actin binding revealed by a beta-III-spectrin SCA5 missense mutation. Nat Commun, 8, 2017
8DPU	The crystal structure of the IL-11 signalling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... 著者 Metcalfe, R.D, Aizel, K, Griffin, M.D.W. 登録日 2022-07-17 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.78 Å) 主引用文献 Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
8DPV	The crystal structure of Interleukin-11, W147A mutant 分子名称: CHLORIDE ION, Interleukin-11, SULFATE ION 著者 Metcalfe, R.D, Griffin, M.D.W. 登録日 2022-07-17 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
6RT0	cryo-em structure of alpha-synuclein fibril polymorph 2A 分子名称: Alpha-synuclein 著者 Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. 登録日 2019-05-22 公開日 2019-06-26 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
8DPS	The structure of the interleukin 11 signalling complex, truncated gp130 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... 著者 Metcalfe, R.D, Hanssen, E, Griffin, M.D.W. 登録日 2022-07-17 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
8DPT	The structure of the IL-11 signalling complex, with full-length extracellular gp130 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ... 著者 Metcalfe, R.D, Hanssen, E, Griffin, M.D.W. 登録日 2022-07-17 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
8DPW	The structure of Interleukin-11 Mutein 分子名称: Interleukin-11, SULFATE ION 著者 Metcalfe, R.D, Griffin, M.D.W. 登録日 2022-07-17 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant. Nat Commun, 14, 2023
3PSF	Crystal Structure of the Spt6 core domain from Saccharomyces cerevisiae, Form Spt6(236-1259) 分子名称: Transcription elongation factor SPT6 著者 Close, D, Hill, C.P. 登録日 2010-12-01 公開日 2011-03-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J.Mol.Biol., 408, 2011

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