8DPW

The structure of Interleukin-11 Mutein

Summary for 8DPW

• Entry DOI: 10.2210/pdb8dpw/pdb
• Descriptor: Interleukin-11, SULFATE ION (3 entities in total)
• Functional Keywords: complex, cytokine, il-6 family cytokine
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 18396.36

Authors

Metcalfe, R.D.,Griffin, M.D.W. (deposition date: 2022-07-17, release date: 2023-11-29)

• Primary citation: Metcalfe, R.D.,Hanssen, E.,Fung, K.Y.,Aizel, K.,Kosasih, C.C.,Zlatic, C.O.,Doughty, L.,Morton, C.J.,Leis, A.P.,Parker, M.W.,Gooley, P.R.,Putoczki, T.L.,Griffin, M.D.W.; Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant; Nat Commun, 14:7543-, 2023; DOI: 10.1038/s41467-023-42754-w

Experimental method

X-RAY DIFFRACTION (1.8 Å)