3B36
 
 | | Structure of M26L DJ-1 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Protein DJ-1 | | 著者 | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | | 登録日 | 2007-10-19 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
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3CYF
 | | Crystal Structure of E18N DJ-1 | | 分子名称: | Protein DJ-1 | | 著者 | Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hasim, S, Pozharski, E, Wilson, M.A. | | 登録日 | 2008-04-25 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
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3CZ9
 | | Crystal Structure of E18L DJ-1 | | 分子名称: | O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, Protein DJ-1 | | 著者 | Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hasim, S, Pozharski, E, Wilson, M.A. | | 登録日 | 2008-04-28 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
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3CZA
 | | Crystal Structure of E18D DJ-1 | | 分子名称: | MALONIC ACID, Protein DJ-1 | | 著者 | Witt, A.C, Lakshminarasimhan, M, Remington, B.C, Hashim, S, Pozharski, E, Wilson, M.A. | | 登録日 | 2008-04-28 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Cysteine pKa depression by a protonated glutamic acid in human DJ-1.
Biochemistry, 47, 2008
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2GRQ
 | | Crystal Structure of human RanGAP1-Ubc9-D127A | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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2R5Y
 | | Structure of Scr/Exd complex bound to a consensus Hox-Exd site | | 分子名称: | DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DTP*DGP*DAP*DTP*DTP*DTP*DAP*DTP*DGP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DCP*DAP*DTP*DAP*DAP*DAP*DTP*DCP*DAP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ... | | 著者 | Aggarwal, A.K, Passner, J.M, Jain, R. | | 登録日 | 2007-09-04 | | 公開日 | 2008-02-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Functional specificity of a Hox protein mediated by the recognition of minor groove structure
Cell(Cambridge,Mass.), 131, 2007
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2R5Z
 | | Structure of Scr/Exd complex bound to a DNA sequence derived from the fkh gene | | 分子名称: | DNA (5'-D(*DAP*DCP*DTP*DCP*DTP*DAP*DAP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DGP*DGP*DCP*DTP*DG)-3'), DNA (5'-D(*DTP*DCP*DAP*DGP*DCP*DCP*DGP*DAP*DTP*DTP*DAP*DAP*DTP*DCP*DTP*DTP*DAP*DGP*DAP*DG)-3'), Homeobox protein extradenticle, ... | | 著者 | Aggarwal, A.K, Passner, J.M, Jain, R. | | 登録日 | 2007-09-04 | | 公開日 | 2008-02-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Functional specificity of a Hox protein mediated by the recognition of minor groove structure
Cell(Cambridge,Mass.), 131, 2007
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2GRP
 | | Crystal Structure of human RanGAP1-Ubc9-Y87A | | 分子名称: | Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I | | 著者 | Yunus, A.A, Lima, C.D. | | 登録日 | 2006-04-24 | | 公開日 | 2006-05-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
Nat.Struct.Mol.Biol., 13, 2006
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6DCG
 | | Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology | | 分子名称: | (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | | 著者 | Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. | | 登録日 | 2018-05-06 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
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3QFA
 | | Crystal structure of the human thioredoxin reductase-thioredoxin complex | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | 著者 | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | | 登録日 | 2011-01-21 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
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3QFB
 | | Crystal structure of the human thioredoxin reductase-thioredoxin complex | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | | 著者 | Fritz-Wolf, K, Kehr, S, Stumpf, M, Rahlfs, S, Becker, K. | | 登録日 | 2011-01-21 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of the human thioredoxin reductase-thioredoxin complex
Nat Commun, 2, 2011
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7PSX
 | | Structure of HOXB13 bound to hydroxymethylated DNA | | 分子名称: | DNA (5'-D(P*GP*GP*AP*CP*CP*TP*5HCP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13, ... | | 著者 | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | | 登録日 | 2021-09-24 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of HOXB13 bound to hydroxymethylated DNA
To Be Published
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1PDW
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1PDV
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4CRL
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7LB3
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4BTE
 | | DJ-1 Cu(I) complex | | 分子名称: | COPPER (I) ION, PROTEIN DJ-1 | | 著者 | Puno, M.R.A, Odell, M, Moody, P.C.E. | | 登録日 | 2013-06-14 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Structure of Cu(I)-Bound Dj-1 Reveals a Biscysteinate Metal Binding Site at the Homodimer Interface: Insights Into Mutational Inactivation of Dj-1 in Parkinsonism.
J.Am.Chem.Soc., 135, 2013
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4D10
 | | Crystal structure of the COP9 signalosome | | 分子名称: | COP9 SIGNALOSOME COMPLEX SUBUNIT 1, COP9 SIGNALOSOME COMPLEX SUBUNIT 2, COP9 SIGNALOSOME COMPLEX SUBUNIT 3, ... | | 著者 | Bunker, R.D, Lingaraju, G.M, Thoma, N.H. | | 登録日 | 2014-04-30 | | 公開日 | 2014-07-23 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Crystal Structure of the Human Cop9 Signalosome
Nature, 512, 2014
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2H9P
 | | WDR5 in complex with trimethylated H3K4 peptide | | 分子名称: | H3 histone, WD-repeat protein 5 | | 著者 | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-06-10 | | 公開日 | 2006-08-01 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
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5NP0
 | | Closed dimer of human ATM (Ataxia telangiectasia mutated) | | 分子名称: | Serine-protein kinase ATM | | 著者 | Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L. | | 登録日 | 2017-04-13 | | 公開日 | 2017-05-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | | 主引用文献 | Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
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6X93
 | | Interleukin-10 signaling complex with IL-10RA and IL-10RB | | 分子名称: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | | 著者 | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | | 登録日 | 2020-06-02 | | 公開日 | 2021-03-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10.
Science, 371, 2021
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5TUU
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6FCM
 | | Crystal structure of human PCNA | | 分子名称: | Proliferating cell nuclear antigen | | 著者 | Housset, D, Frachet, P. | | 登録日 | 2017-12-20 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.
J.Exp.Med., 216, 2019
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6FJB
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6FRP
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