4CRL
Crystal structure of human CDK8-Cyclin C in complex with cortistatin A
Summary for 4CRL
Entry DOI | 10.2210/pdb4crl/pdb |
Descriptor | CYCLIN-DEPENDENT KINASE 8, CYCLIN-C, CORTISTATIN A, ... (5 entities in total) |
Functional Keywords | transferase, cyclin-dependent kinase 8, cdk8, cyclin c, ccnc, cortistatin a, mediator kinase, mediator complex, super-enhancer, transcription |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 81288.58 |
Authors | Myers, A.G.,Shair, M.D. (deposition date: 2014-02-27, release date: 2015-09-23, Last modification date: 2023-12-20) |
Primary citation | Pelish, H.E.,Liau, B.B.,Nitulescu, I.I.,Tangpeerachaikul, A.,Poss, Z.C.,Da Silva, D.H.,Caruso, B.T.,Arefolov, A.,Fadeyi, O.,Christie, A.L.,Du, K.,Banka, D.,Schneider, E.V.,Jestel, A.,Zou, G.,Si, C.,Ebmeier, C.C.,Bronson, R.T.,Krivtsov, A.V.,Myers, A.G.,Kohl, N.E.,Kung, A.L.,Armstrong, S.A.,Lemieux, M.E.,Taatjes, D.J.,Shair, M.D. Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml Nature, 526:273-, 2015 Cited by PubMed: 26416749DOI: 10.1038/NATURE14904 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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