4CRL
Crystal structure of human CDK8-Cyclin C in complex with cortistatin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CYCLIN-DEPENDENT KINASE 8 | polymer | 406 | 47105.9 | 1 | UniProt (P49336) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 8, MEDIATOR COMPLEX SUBUNIT CDK8, MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT CDK8, PROTEIN KINASE K35, CDK8 |
| 2 | B (B) | CYCLIN-C | polymer | 285 | 33480.0 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | HOMO SAPIENS (HUMAN) | SRB11 HOMOLOG, HSRB11, CYCLINC |
| 3 | C (A) | CORTISTATIN A | non-polymer | 472.6 | 1 | Chemie (C1I) | |||
| 4 | D, E, F, G, H (A, B) | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80585.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 702.7 | |
| All* | Total formula weight | 81288.6 |
