4CRL
Crystal structure of human CDK8-Cyclin C in complex with cortistatin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CYCLIN-DEPENDENT KINASE 8 | polymer | 406 | 47105.9 | 1 | UniProt (P49336) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 8, MEDIATOR COMPLEX SUBUNIT CDK8, MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT CDK8, PROTEIN KINASE K35, CDK8 |
| 2 | B (B) | CYCLIN-C | polymer | 285 | 33480.0 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | HOMO SAPIENS (HUMAN) | SRB11 HOMOLOG, HSRB11, CYCLINC |
| 3 | C (A) | CORTISTATIN A | non-polymer | 472.6 | 1 | Chemie (C1I) PubChem (11561907) PubChem (44239846) PubChem (44462753) PubChem (177124145) PubChem (177124233) PubChem (90340155) PubChem (58183895) PubChem (73007612) PubChem (89839999) PubChem (101857094) PubChem (118029466) PubChem (118031013) PubChem (122697783) PubChem (126502226) PubChem (129902210) PubChem (132099210) PubChem (141686100) PubChem (145187095) | |||
| 4 | D, E, F, G, H (A, B) | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) PubChem (284) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80585.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 702.7 | |
| All* | Total formula weight | 81288.6 |
